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公开(公告)号：US20220025032A1
公开(公告)日：2022-01-27
申请号：US17375860
申请日：2021-07-14
Applicant: NOVARTIS AG
Inventor： Chad Eric BIGELOW , Ana Maria CARRION , James Edgar CHASTAIN , Kirk Lee CLARK , Bijan Alexandre ETEMAD-GILBERTSON , Joy Gispati GHOSH , Shawn Michael HANKS , Nicole HAUBST , Ganesh Rajan IYER , Nina MOKER , Andrew Anh NGUYEN , Stephen Hendrick POOR , Yubin QIU , Nalini Velamur RANGASWAMY , Michael STEFANIDAKIS , Engin TOKSOZ , Michael Zbigniew TWAROG
Abstract: The present disclosure provides anti-BTC antibodies, methods of producing said antibodies, pharmaceutical compositions comprising said antibodies, and methods of using said antibodies. The present disclosure also provides multi-specific binding molecules, e.g., bispecific antibodies, comprising a BTC binding moiety and an anti-VEGF binding moiety.
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公开(公告)号：US20180327486A1
公开(公告)日：2018-11-15
申请号：US15973225
申请日：2018-05-07
Applicant: NOVARTIS AG
Inventor： Leslie Ngozi Anuna JOHNSON , Ute JAEGER , Yong-In KIM , Christian Carsten Silvester KUNZ , Igor SPLAWSKI , Michael ROGUSKA , Joy GHOSH , Barbara BRANNETTI , Michael STEFANIDAKIS , Sha-Mei LIAO
IPC: C07K16/18 , C07K16/24 , G01N33/68 , A61K39/395
CPC classification number: C07K16/18 , A61K39/3955 , A61K2039/505 , A61K2039/507 , C07K16/24 , C07K2317/21 , C07K2317/30 , C07K2317/33 , C07K2317/40 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6863
Abstract: The present invention relates to antibodies or antigen binding fragments thereof that bind to complement Factor P and used thereof as well as combinations of anti-Factor P antibodies with antibodies or antigen binding fragments thereof that bind to complement component 5 (C5).
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公开(公告)号：US20220356236A1
公开(公告)日：2022-11-10
申请号：US17809941
申请日：2022-06-30
Applicant: NOVARTIS AG
Inventor： Chad Eric BIGELOW , Ana Maria CARRION , James Edgar CHASTAIN , Kirk Lee CLARK , Bijan Alexandre ETEMAD-GILBERTSON , Joy Gispati GHOSH , Shawn Michael HANKS , Nicole HAUBST , Ganesh Rajan IYER , Nina MOKER , Andrew Anh NGUYEN , Stephen Hendrick POOR , Yubin QIU , Nalini Velamur RANGASWAMY , Michael STEFANIDAKIS , Engin TOKSOZ , Michael Zbigniew TWAROG
Abstract: The present disclosure provides anti-BTC antibodies, methods of producing said antibodies, pharmaceutical compositions comprising said antibodies, and methods of using said antibodies. The present disclosure also provides multi-specific binding molecules, e.g., bispecific antibodies, comprising a BTC binding moiety and an anti-VEGF binding moiety.
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公开(公告)号：US20220348646A1
公开(公告)日：2022-11-03
申请号：US17809943
申请日：2022-06-30
Applicant: NOVARTIS AG
Inventor： Chad Eric BIGELOW , Ana Maria CARRION , James Edgar CHASTAIN , Kirk Lee CLARK , Bijan Alexandre ETEMAD-GILBERTSON , Joy Gispati GHOSH , Shawn Michael HANKS , Nicole HAUBST , Ganesh Rajan IYER , Nina MOKER , Andrew Anh NGUYEN , Stephen Hendrick POOR , Yubin QIU , Nalini Velamur RANGASWAMY , Michael STEFANIDAKIS , Engin TOKSOZ , Michael Zbigniew TWAROG
Abstract: The present disclosure provides anti-BTC antibodies, methods of producing said antibodies, pharmaceutical compositions comprising said antibodies, and methods of using said antibodies. The present disclosure also provides multi-specific binding molecules, e.g., bispecific antibodies, comprising a BTC binding moiety and an anti-VEGF binding moiety.
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