公开(公告)号：US20220306617A1

公开(公告)日：2022-09-29

申请号：US17638106

申请日：2020-08-24

Applicant: NOVARTIS AG

Inventor： Claire ADCOCK ,  Jake AXFORD ,  Ying HOU ,  Hyungchul KIM ,  Yiping SHEN ,  Nichola SMITH ,  Catherine Fooks SOLOVAY ,  Moo Je SUNG ,  Megan LIGHTFOOT ,  Alessandro MAZZACANI ,  Emily STANLEY ,  Lewis WHITEHEAD

IPC: C07D413/10 ,  A61K31/422 ,  A61K45/06 ,  C07D413/14 ,  A61K31/454 ,  A61K31/5377 ,  A61K31/675 ,  C07F9/6558 ,  A61P11/00

Abstract: The invention relates to heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification; capable of modulating the ctivity of TMEM16a. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including COPD, bronchiectasis, asthma, cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, cystic fibrosis, primary ciliary dyskinesia, respiratory tract infections (acute and chronic; viral and bacterial), lung carcinoma.

公开(公告)号：US20220071971A1

公开(公告)日：2022-03-10

申请号：US17415335

申请日：2019-12-18

Applicant: NOVARTIS AG

Inventor： Mihai Azimioara ,  Badry Bursulaya ,  Songchun Jiang ,  Casey Jacob Nelson MATHISON ,  Victor Ivanovich NIKULIN ,  Truc Ngoc NGUYEN ,  Barun OKRAM ,  Sejal PATEL ,  Dean Paul PHILLIPS ,  Lewis WHITEHEAD ,  Baogen WU ,  Shanshan YAN ,  Xuefeng ZHU

IPC: A61K31/439 ,  A61K45/06 ,  C07D515/18 ,  C07D513/22 ,  C07D513/18 ,  A61K31/5377

Abstract: The invention relates to heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.