公开(公告)号：US20220127247A1

公开(公告)日：2022-04-28

申请号：US17428353

申请日：2020-02-04

Applicant: NOVARTIS AG

Inventor： Mihai AZIMIOARA ,  Bei CHEN ,  Robert EPPLE ,  James Paul LAJINESS ,  Casey Jacob Nelson MATHISON ,  Juliet NABAKKA ,  Victor Ivanovich NIKULIN ,  Sejal PATEL ,  Dean Paul PHILLIPS ,  Paul Vincent RUCKER ,  Andrew VALIERE ,  Baogen WU ,  Shanshan YAN ,  Xuefeng ZHU

IPC: C07D401/12 ,  C07D401/14 ,  A61K45/06 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/496 ,  C07D405/14

Abstract: The invention relates to heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.

公开(公告)号：US20240247042A1

公开(公告)日：2024-07-25

申请号：US18556461

申请日：2022-04-20

Applicant: Novartis AG

Inventor： Valerie BEAULIEU ,  Keith GALYAN ,  Jinhai GAO ,  Carol GINSBURG-MORAFF ,  Pankaj JAIN ,  Jovita MARCINKEVICIENE ,  Walter MICHAEL ,  Muneto MOGI ,  Martin MARRO ,  Sejal PATEL ,  Scott PLUMMER ,  Alok SINGH ,  Aimee USERA

IPC: C07K14/605 ,  A61K38/00 ,  A61K47/54 ,  A61P3/04

CPC classification number: C07K14/605 ,  A61K47/542 ,  A61P3/04 ,  A61K38/00

Abstract: Provided herein are novel compounds comprising a GLP-1 compound and a fatty acid or fatty acid derivative, the manufacture of said novel compounds and the use thereof.

公开(公告)号：US20220071971A1

公开(公告)日：2022-03-10

申请号：US17415335

申请日：2019-12-18

Applicant: NOVARTIS AG

Inventor： Mihai Azimioara ,  Badry Bursulaya ,  Songchun Jiang ,  Casey Jacob Nelson MATHISON ,  Victor Ivanovich NIKULIN ,  Truc Ngoc NGUYEN ,  Barun OKRAM ,  Sejal PATEL ,  Dean Paul PHILLIPS ,  Lewis WHITEHEAD ,  Baogen WU ,  Shanshan YAN ,  Xuefeng ZHU

IPC: A61K31/439 ,  A61K45/06 ,  C07D515/18 ,  C07D513/22 ,  C07D513/18 ,  A61K31/5377

Abstract: The invention relates to heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.

公开(公告)号：US20180072673A1

公开(公告)日：2018-03-15

申请号：US15688089

申请日：2017-08-28

Applicant: Novartis AG

Inventor： Dean Paul Phillips ,  Mihai AZIMIOARA ,  Bei CHEN ,  Robert EPPLE ,  Victor Ivanovich NIKULIN ,  Rodrigo A. RODRIGUEZ ,  Sejal PATEL ,  Ayako HONDA

IPC: C07D213/76 ,  A61K31/444 ,  A61K45/06 ,  C07D401/14 ,  A61K31/4545 ,  A61K31/496 ,  C07D405/14 ,  C07D487/10 ,  C07D493/08 ,  C07D491/107 ,  C07D487/04 ,  A61K31/4985 ,  A61K31/5377 ,  A61K31/46

Abstract: The invention relates to heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.