公开(公告)号：US10106605B2

公开(公告)日：2018-10-23

申请号：US15180879

申请日：2016-06-13

Applicant: Novartis AG

Inventor： Joy Ghosh ,  Mark Anthony Rutz ,  Kathrin Ulrike Tissot-Daguette ,  Igor Splawski ,  Michael Roguska

IPC: A61K39/00 ,  C07K16/22 ,  C07K16/26 ,  C07K16/28 ,  A61K39/395 ,  A61K45/06

Abstract: The present invention relates to compositions and methods for the inhibition of EPO. The invention provides antibodies and antigen binding fragments thereof that bind to EPO and are able to inhibit EPO-dependent cell proliferation and/or EPO-dependent cell signaling.

公开(公告)号：US10385127B2

公开(公告)日：2019-08-20

申请号：US16130166

申请日：2018-09-13

Applicant: NOVARTIS AG

Inventor： Joy Ghosh ,  Mark Anthony Rutz ,  Kathrin Ulrike Tissot-Daguette ,  Igor Splawski ,  Michael Roguska

IPC: C12N15/09 ,  C12N5/00 ,  C12N15/63 ,  C07K16/26 ,  A61K45/06 ,  A61K39/395 ,  C07K16/22 ,  A61K39/00

Abstract: The present invention relates to compositions and methods for the inhibition of EPO. The invention provides antibodies and antigen binding fragments thereof that bind to EPO and are able to inhibit EPO-dependent cell proliferation and/or EPO-dependent cell signaling.