公开(公告)号：US20240247042A1

公开(公告)日：2024-07-25

申请号：US18556461

申请日：2022-04-20

Applicant: Novartis AG

Inventor： Valerie BEAULIEU ,  Keith GALYAN ,  Jinhai GAO ,  Carol GINSBURG-MORAFF ,  Pankaj JAIN ,  Jovita MARCINKEVICIENE ,  Walter MICHAEL ,  Muneto MOGI ,  Martin MARRO ,  Sejal PATEL ,  Scott PLUMMER ,  Alok SINGH ,  Aimee USERA

IPC: C07K14/605 ,  A61K38/00 ,  A61K47/54 ,  A61P3/04

CPC classification number: C07K14/605 ,  A61K47/542 ,  A61P3/04 ,  A61K38/00

Abstract: Provided herein are novel compounds comprising a GLP-1 compound and a fatty acid or fatty acid derivative, the manufacture of said novel compounds and the use thereof.

公开(公告)号：US20190231765A1

公开(公告)日：2019-08-01

申请号：US16341075

申请日：2017-10-13

Applicant: NOVARTIS AG

Inventor： Christopher ADAMS ,  Muneto MOGI ,  Stephen Hedrick POOR ,  Timothy Michael RAMSEY ,  Henry WU ,  Qin ZHANG

IPC: A61K31/4439 ,  A61P27/02 ,  A61K9/00

Abstract: The present invention provides in one aspect methods for treating ocular diseases by administering pharmaceutical compositions comprising an inhibitor of colony stimulating factor-1 (CSF-1) receptors. In another aspect, the present invention provides pharmaceutical compositions for treating ocular diseases, the compositions comprising at least one inhibitor of CSF-1R. The inhibitor can also be a selective inhibitor of CSF-1R in certain embodiments.

公开(公告)号：US20220162170A1

公开(公告)日：2022-05-26

申请号：US17430819

申请日：2020-02-13

Applicant: Novartis AG

Inventor： Joseph Paul BULLOCK ,  Chinmay MAHESHWARI ,  Quintus MEDLEY ,  Muneto MOGI ,  Michela MONTECCHI-PALMER ,  Gregory MORANDI ,  Michael MUTZ ,  Kalliopi STASI ,  Christopher Stephen TOWLER

IPC: C07D239/91

Abstract: The present disclosure provides polymorphs and formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I). The present disclosure further provides methods for treating ocular surface pain by administering 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I). The present invention also provides methods for treating dry eye disease and ocular hyperemia by administering 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile.

公开(公告)号：US20210275529A1

公开(公告)日：2021-09-09

申请号：US17225290

申请日：2021-04-08

Applicant: NOVARTIS AG

Inventor： Quintus MEDLEY ,  Muneto MOGI ,  Michela MONTECCHI-PALMER ,  Kalliopi STASI

IPC: A61K31/517

Abstract: The present invention provides methods for treating ocular surface pain by administering 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I). The present invention also provides methods for treating dry eye disease and ocular hyperemia by administering 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile.

公开(公告)号：US20200261457A1

公开(公告)日：2020-08-20

申请号：US16789976

申请日：2020-02-13

Applicant: NOVARTIS AG

Inventor： Joseph Paul BULLOCK ,  Chinmay MAHESHWARI ,  Quintus MEDLEY ,  Muneto MOGI ,  Michela MONTECCHI-PALMER ,  Kali STASI

IPC: A61K31/517 ,  A61K47/38 ,  A61K47/02 ,  A61K47/26 ,  A61K47/10

Abstract: The present invention provides formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I) and methods for treating ocular surface pain by administering such formulations. The present invention also provides methods for treating dry eye disease and ocular hyperemia by administering formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile.

公开(公告)号：US20220193078A1

公开(公告)日：2022-06-23

申请号：US17653982

申请日：2022-03-08

Applicant: NOVARTIS AG

Inventor： Quintus MEDLEY ,  Muneto MOGI ,  Michela MONTECCHI-PALMER ,  Kalliopi STASI

IPC: A61K31/517

Abstract: The present invention provides methods for treating ocular surface pain by administering 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I). The present invention also provides methods for treating dry eye disease and ocular hyperemia by administering 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile.

公开(公告)号：US20190119254A1

公开(公告)日：2019-04-25

申请号：US16216420

申请日：2018-12-11

Applicant: NOVARTIS AG

Inventor： Christopher M. ADAMS ,  Doug BEVAN ,  Michael Paul CAPPARELLI ,  Takeru EHARA ,  Luciana FERRARA ,  Nan Ji ,  Erik MEREDITH ,  Muneto MOGI ,  James J. POWERS ,  Ganesh PRASANNA ,  Nello MAINOLFI ,  Mitsunori KATO

IPC: C07D401/14 ,  C07D405/14 ,  A61K31/4545 ,  A61K31/4725 ,  A61K9/00 ,  C07D413/14 ,  A61K31/454 ,  C07D401/12 ,  C07D401/10 ,  A61K31/4439

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

公开(公告)号：US20240336598A1

公开(公告)日：2024-10-10

申请号：US18589841

申请日：2024-02-28

Applicant: Novartis AG

Inventor： Daniela ANGST ,  Philippe Bolduc ,  Matthew William Carson ,  Atwood Kim CHEUNG ,  Véronique Darsigny ,  Xiang GAO ,  Viktor HORNAK ,  Keith JENDZA ,  Rajesh KARKI ,  Ajay Kumar LAL ,  Gang LIU ,  Justin Yik Ching MAO ,  Jeffrey M. McKENNA ,  Erik MEREDITH ,  Muneto MOGI ,  Vivek RAUNIYAR ,  Liansheng SU ,  Ritesh TICHKULE ,  Shuangxi WANG ,  Chun ZHANG ,  Liang ZHAO ,  Rui ZHENG

IPC: C07D403/14 ,  A61K31/517 ,  A61K31/55 ,  A61K45/06 ,  C07D239/95 ,  C07D401/12 ,  C07D401/14

CPC classification number: C07D403/14 ,  A61K31/517 ,  A61K31/55 ,  A61K45/06 ,  C07D239/95 ,  C07D401/12 ,  C07D401/14

Abstract: The disclosure relates to a compound of Formula (I):




or a pharmaceutically acceptable salt thereof wherein A, Ra to Rd, and R4 to R7, are as described herein, as well as compositions and methods of using such compounds.

公开(公告)号：US20230139170A1

公开(公告)日：2023-05-04

申请号：US17930578

申请日：2022-09-08

Applicant: Novartis AG

Inventor： Joseph Paul BULLOCK ,  Chinmay MAHESHWARI ,  Quintus MEDLEY ,  Muneto MOGI ,  Michela MONTECCHI-PALMER ,  Kalliopi STASI

IPC: A61K31/517 ,  A61K47/02 ,  A61K47/10 ,  A61K47/26 ,  A61K47/38

Abstract: The present invention provides formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I) and methods for treating ocular surface pain by administering such formulations. The present invention also provides methods for treating dry eye disease and ocular hyperemia by administering formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile.

公开(公告)号：US20200261456A1

公开(公告)日：2020-08-20

申请号：US16789963

申请日：2020-02-13

Applicant: NOVARTIS AG

Inventor： Quintus MEDLEY ,  Muneto MOGI ,  Michela MONTECCHI-PALMER ,  Kali STASI

IPC: A61K31/517

Abstract: The present invention provides methods for treating ocular surface pain by administering 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I). The present invention also provides methods for treating dry eye disease and ocular hyperemia by administering 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile.