公开(公告)号：US20240092918A1

公开(公告)日：2024-03-21

申请号：US18164519

申请日：2023-02-03

Applicant: Novartis AG

Inventor： Steven BENDER ,  Tracy CHARLTON ,  Anna GALKIN ,  Bernhard Hubert GEIERSTANGER ,  Scott Martin GLASER ,  Shailaja KASIBHATLA ,  Mark KNUTH ,  Sabine ROTTMANN ,  Sarah RUE ,  Glen SPRAGGON ,  Tetsuo UNO

IPC: C07K16/28 ,  A61K47/68 ,  A61P35/00

CPC classification number: C07K16/2866 ,  A61K47/6803 ,  A61K47/6849 ,  A61P35/00 ,  A61K2039/505

Abstract: This application discloses anti-CCR7 antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments. The invention also relates to methods of treating or preventing cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.

公开(公告)号：US20200216548A1

公开(公告)日：2020-07-09

申请号：US16482173

申请日：2018-02-01

Applicant: NOVARTIS AG

Inventor： Steven BENDER ,  Tracy CHARLTON ,  Anna GALKIN ,  Bernhard Hubert GEIERSTANGER ,  Scott Martin GLASER ,  Shailaja KASIBHATLA ,  Mark KNUTH ,  Sabine ROTTMANN ,  Sarah RUE ,  Glen SPRAGGON ,  Tetsuo UNO

IPC: C07K16/28 ,  A61K47/68 ,  A61P35/00

Abstract: This application discloses anti-CCR7 antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments. The invention also relates to methods of treating or preventing cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.

公开(公告)号：US20170158747A1

公开(公告)日：2017-06-08

申请号：US15367003

申请日：2016-12-01

Applicant: Novartis AG

Inventor： Michael DIDONATO ,  Mark KNUTH ,  Shelly MEEUSEN ,  Glen SPRAGGON

IPC: C07K14/54 ,  A61K38/20 ,  A61K39/395 ,  C07K16/00 ,  A61K45/06

CPC classification number: C07K14/5428 ,  A61K38/2066 ,  A61K39/395 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/00 ,  C07K2317/51 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/71 ,  C07K2318/10 ,  C07K2319/31

Abstract: The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through interleukin 10 receptor. Provided antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro-inflammatory effects in the treatment, amelioration and prophylaxis of immune related disorders. Additionally provided are polynucleotides and vectors that encode antibody cytokine engrafted proteins and host cells capable of producing antibody cytokine engrafted proteins, as well as methods of combining antibody cytokine engrafted proteins with other therapeutics in treating immune related disorder.