公开(公告)号：US11987644B2

公开(公告)日：2024-05-21

申请号：US16844999

申请日：2020-04-09

Applicant: NOVARTIS AG

Inventor： Michael Otto Bardroff ,  Tina Buch ,  Christian Graf ,  Daniel Heitmann ,  Thomas Jostock ,  Hans-Peter Knopf ,  Rolf Koehler ,  Jiri Kovarik ,  Stephen John Oliver ,  Dhavalkumar Patel ,  Maximilian Woisetschlaeger

IPC: C07K16/00 ,  A61P1/00 ,  A61P9/00 ,  A61P9/10 ,  A61P9/14 ,  C07K16/24 ,  C07K16/28 ,  C07K16/46

CPC classification number: C07K16/468 ,  A61P1/00 ,  A61P9/10 ,  A61P9/14 ,  C07K16/00 ,  C07K16/244 ,  C07K16/245 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/46 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2319/00

Abstract: The invention relates to bivalent bispecific monoclonal antibodies (bbmAb) or variants thereof, and methods of manufacturing such antibodies by co-expressing modified Fc-mutated derivatives of two different monoclonal antibodies in mammalian cell lines.