公开(公告)号：US3804861A

公开(公告)日：1974-04-16

申请号：US31181172

申请日：1972-12-04

Applicant: NOVO TERAPEUTISK LABOR AS

Inventor： CHRISTENSEN H ,  LUNDT B ,  GRONVALD F ,  ANDERSEN W

IPC: A61K31/64 ,  C07D307/79 ,  C07D311/58 ,  C07D7/32

CPC classification number: C07D307/79 ,  A61K31/64 ,  C07D311/58

Abstract: THE INVENTION PROCESS NOVEL CHROMAN-8-CARBOXYLIC ACIDS OF THE FORMULA:

6-R,8-(HOOC-)CHROMAN

IN WHICH R IS BROMINE, CHLORINE, METHYL OR METHOXY. THESE CARBOXYLIC ACIDS ARE USEFUL AS INTERMEDIATES IN THE PRODUCTION OF PHYSIOLOGICALLY ACTIVE COMPOUNDS. THEY ARE PARTICULARLY USEFUL IN THE PRODUCTION OF ANTIDIABETIC BENZENESULFONYLUREA AND BEBZENESULFONYLSEMICARBAZIDE DERIVATIVES.

公开(公告)号：US3803176A

公开(公告)日：1974-04-09

申请号：US31181272

申请日：1972-12-04

Applicant: NOVO TERAPEUTISK LABOR AS

Inventor： CHRISTENSEN H ,  ANDERSEN W ,  LUNDT B ,  GRONVALD F

IPC: A61K31/64 ,  C07D307/79 ,  C07D311/58 ,  C07D7/32

CPC classification number: A61K31/64 ,  C07D307/79 ,  C07D311/58 ,  Y10S514/866

Abstract: THE INVENTION PROVIDES NOVEL SULFONYLUREA DERIVATIVES OF THE FORMULA:

3-R4,4-R3,6-R2,8-((4-(R1-NH-CO-NH-SO2-)PHENYL)-CH2-CH2-NH-

CO-)-3,4-DIHYDRO-2H-CHROMENE

AND SALTS THEREOF, IN WHICH R1 IS N-BUTYL, ISOBUTYL, CYCLOPENTYL, CYCLOHEXYL, 4-METHYLCYCLOHEXYL, CYCLOHEXENYL OR ENDOETHYLENECLOHEXYL, R2 IS METHYL, METHOXY, CHLORINE, BROMINE OR HYDROGEN, R3 AND R4 ARE EACH HYDROGEN, OR R3 AND R4 MAY TOGETHER FORM AN ADDITIONAL BOND IN WHICH CASE R2 IS CHLORINE, ONLY. THESE COMPOUNDS ARE USEFUL IN THE ORAL TREATMENT OF DIABETES MELLITUS.