公开(公告)号：US20220213122A1

公开(公告)日：2022-07-07

申请号：US17457397

申请日：2021-12-02

Applicant: NUVATION BIO INC.

Inventor： Son Minh PHAM ,  Sarvajit Chakravarty ,  Jayakanth Kankanala ,  Jiyun Chen ,  Anjan Kumar Nayak ,  Anup Barde

IPC: C07D513/04 ,  A61P35/00 ,  C07D213/89 ,  C07D471/04 ,  C07D239/36 ,  C07D237/22 ,  C07D239/90 ,  C07D417/12 ,  C07D401/12 ,  C07D409/12 ,  C07D411/10 ,  C07D491/048 ,  C07D495/04 ,  C07D498/04

Abstract: Novel bromodomain and extraterminal domain (BET) inhibitors and to therapeutic methods of treating conditions and diseases using these novel BET inhibitors are provided.

公开(公告)号：US11034669B2

公开(公告)日：2021-06-15

申请号：US16698490

申请日：2019-11-27

Applicant: Nuvation Bio Inc.

Inventor： Sarvajit Chakravarty ,  Son Minh Pham ,  Jiyun Chen ,  Jayakanth Kankanala ,  Jeremy D. Pettigrew ,  Anjan Kumar Nayak ,  Anup Barde ,  Brahmam Pujala

IPC: C07D417/12 ,  A61K31/427 ,  C07D401/12 ,  A61P35/04 ,  C07D401/14 ,  C07D403/12 ,  C07D417/14 ,  C07D471/04 ,  A61K9/00 ,  A61K45/06

Abstract: The disclosure relates to anti-cancer compounds derived from nuclear steroid receptor binders, to products containing the same, as well as to methods of their use and preparation.

公开(公告)号：US11826430B2

公开(公告)日：2023-11-28

申请号：US15931495

申请日：2020-05-13

Applicant: Nuvation Bio Inc.

Inventor： David Hung ,  Son Minh Pham ,  Sarvajit Chakravarty ,  Jiyun Chen ,  Jayakanth Kankanala ,  Jeremy D. Pettigrew ,  Anup Barde ,  Anjan Kumar Nayak

IPC: C07D471/04 ,  C07D471/06 ,  C07D401/12 ,  A61K47/55 ,  A61K31/4745 ,  C07D401/14 ,  C07D403/12 ,  A61K9/00 ,  A61K47/68 ,  A61K31/502 ,  A61K31/55 ,  A61K31/5377 ,  A61K31/498 ,  A61K31/52 ,  A61K31/5025 ,  A61K31/438 ,  A61K31/519 ,  A61K31/4985

CPC classification number: A61K47/55 ,  A61K9/0053 ,  A61K31/438 ,  A61K31/4745 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/502 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/55 ,  A61K47/6877 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D471/04 ,  C07D471/06

Abstract: The disclosure relates to anti-cancer compounds derived from nuclear steroid receptor binders, to products containing the same, as well as to methods of their use and preparation.

公开(公告)号：US10793561B2

公开(公告)日：2020-10-06

申请号：US16039301

申请日：2018-07-18

Applicant: NUVATION BIO INC.

Inventor： Son Minh Pham ,  Jiyun Chen ,  Amantullah Ansari ,  Pradeep S. Jadhavar ,  Varshavekumar S. Patil ,  Farha Khan ,  Sreekanth A. Ramachandran ,  Anil Kumar Agarwal ,  Sarvajit Chakravarty

IPC: C07D471/04 ,  C07D519/00

Abstract: 1,8-naphthyridinone compounds as modulators of an adenosine receptor are provided. The compounds may find use as therapeutic agents for the treatment of diseases mediated through a G-protein-coupled receptor signaling pathway and may find particular use in oncology.

公开(公告)号：US20200239433A1

公开(公告)日：2020-07-30

申请号：US16698490

申请日：2019-11-27

Applicant: Nuvation Bio Inc.

Inventor： Sarvajit Chakravarty ,  Son Minh Pham ,  Jiyun Chen ,  Jayakanth Kankanala ,  Jeremy D. Pettigrew ,  Anjan Kumar Nayak ,  Anup Barde ,  Brahmam Pujala

IPC: C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D401/14 ,  C07D417/14 ,  C07D471/04 ,  A61P35/04

Abstract: The disclosure relates to anti-cancer compounds derived from nuclear steroid receptor binders, to products containing the same, as well as to methods of their use and preparation.

公开(公告)号：US12208141B2

公开(公告)日：2025-01-28

申请号：US18472993

申请日：2023-09-22

Applicant: Nuvation Bio Inc.

Inventor： David Hung ,  Son Minh Pham ,  Sarvajit Chakravarty ,  Jiyun Chen ,  Jayakanth Kankanala ,  Jeremy D. Pettigrew ,  Anup Barde ,  Anjan Kumar Nayak

IPC: A61K47/55 ,  A61K9/00 ,  A61K31/438 ,  A61K31/4745 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/502 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/55 ,  A61K47/68 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D471/04 ,  C07D471/06

Abstract: The disclosure relates to anti-cancer compounds derived from nuclear steroid receptor binders, to products containing the same, as well as to methods of their use and preparation.

公开(公告)号：US20230339964A1

公开(公告)日：2023-10-26

申请号：US18152049

申请日：2023-01-09

Applicant: NUVATION BIO INC

Inventor： Son Minh PHAM ,  Sarvajit Chakravarty ,  Jayakanth Kankanaka ,  Jiyun Chen ,  Chris P. Miller ,  Jeremy D. Pettigrew ,  Anjan Kumar Nayak ,  Anup Barde

IPC: C07D495/04

CPC classification number: C07D495/04

Abstract: Novel bromodomain and extraterminal domain (BET) inhibitors and to therapeutic methods of treating conditions and diseases using these novel BET inhibitors are provided.

公开(公告)号：US11174252B2

公开(公告)日：2021-11-16

申请号：US16277355

申请日：2019-02-15

Applicant: NUVATION BIO INC.

Inventor： Son Minh Pham ,  Sarvajit Chakravarty ,  Jayakanth Kankanala ,  Brahmam Pujala ,  Amit Shete ,  Bhawana Bhatt ,  Anil Kumar Agarwal ,  Sanjeev Soni ,  Jiyun Chen

IPC: C07D413/14 ,  A61P35/00

Abstract: Heterocyclic compounds of Formula (J) as CDK4 or CDK6 or other CDK inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.

公开(公告)号：US11292782B2

公开(公告)日：2022-04-05

申请号：US16698486

申请日：2019-11-27

Applicant: Nuvation Bio Inc.

Inventor： Sarvajit Chakravarty ,  Son Minh Pham ,  Jiyun Chen ,  Jayakanth Kankanala ,  Jeremy D. Pettigrew ,  Anjan Kumar Nayak ,  Anup Barde ,  Brahmam Pujala

IPC: C07D401/04 ,  C07D401/14 ,  C07D403/12 ,  C07D471/04 ,  C07D233/86 ,  C07D417/12 ,  C07D403/10 ,  C07D413/12 ,  C07D493/10 ,  C07D235/02 ,  C07D233/72 ,  A61P35/00 ,  A61K45/06

Abstract: The disclosure relates to anti-cancer compounds derived from nuclear steroid receptor binders, to products containing the same, as well as to methods of their use and preparation.

公开(公告)号：US11028058B2

公开(公告)日：2021-06-08

申请号：US16039307

申请日：2018-07-18

Applicant: NUVATION BIO INC.

Inventor： Son Minh Pham ,  Jiyun Chen ,  Amantullah Ansari ,  Pradeep S. Jadhavar ,  Varshavekumar S. Patil ,  Farha Khan ,  Sreekanth A. Ramachandran ,  Anil Kumar Agarwal ,  Sarvajit Chakravarty

IPC: C07D241/20 ,  C07D403/04 ,  C07D407/04 ,  C07D401/04 ,  C07D413/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D403/14 ,  C07D401/14 ,  A61P35/00

Abstract: Aminopyrazine compounds as modulators of an adenosine receptor are provided. The compounds may find use as therapeutic agents for the treatment of diseases mediated through a G-protein-coupled receptor signaling pathway and may find particular use in oncology.