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公开(公告)号：US20070141620A1
公开(公告)日：2007-06-21
申请号：US11674476
申请日：2007-02-13
IPC分类号： C12Q1/68
CPC分类号： A61K47/60 , Y10S514/825 , Y10S514/903
摘要： PEG-IFN-β conjugates, where a PEG moiety is covalently bound to Cys17 of human IFN-β, are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory diseases are also provided. The invention further relates to a method for the stepwise attachment of PEG moieties in series to a polypeptide, and more particularly to IFN-β.
摘要翻译： 其中PEG部分共价结合人IFN-β的Cys 17的PEG-IFN-β缀合物通过用硫醇反应性聚乙二醇化剂进行位点特异性PEG化的方法产生。 还提供了用于治疗感染，肿瘤和自身免疫性和炎性疾病的药物组合物和方法。 本发明还涉及将PEG部分逐步连接到多肽，更具体地说涉及IFN-β的方法。
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2.发明授权Polyol-IFN-&bgr;conjugates modified at Cys-17 and composition containing same 有权在Cys-17修饰的多元醇-β-IFN-betaconjugates和含有它的组合物公开(公告)号：US06638500B1
公开(公告)日：2003-10-28
申请号：US09698133
申请日：2000-10-30
IPC分类号： A61K3821
CPC分类号： A61K47/60 , Y10S514/825 , Y10S514/903
摘要： PEG-IFN-&bgr; conjugates, where a PEG moiety is covalently bound to Cys17 of human IFN-&bgr;, are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory diseases are also provided. The invention further relates to a method for the stepwise attachment of PEG moieties in series to a polypeptide, and more particularly to IFN-&bgr;.
摘要翻译： 其中PEG部分与人IFN-β的Cys 17共价结合的PEG-IFN-β缀合物通过用硫醇反应性聚乙二醇化剂进行位点特异性PEG化的方法产生。 还提供了用于治疗感染，肿瘤和自身免疫性和炎性疾病的药物组合物和方法。 本发明还涉及将PEG部分逐步连接到多肽，更具体地说涉及IFN-β的方法。
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公开(公告)号：US07700314B2
公开(公告)日：2010-04-20
申请号：US11674476
申请日：2007-02-13
CPC分类号： A61K47/60 , Y10S514/825 , Y10S514/903
摘要： PEG-IFN-β conjugates, where a PEG moiety is covalently bound to Cys17 of human IFN-β, are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory diseases are also provided. The invention further relates to a method for the stepwise attachment of PEG moieties in series to a polypeptide, and more particularly to IFN-β.
摘要翻译： PEG-IFN- 通过用硫醇反应性聚乙二醇化剂进行位点特异性PEG化的方法，其中PEG部分共价结合人IFN-和bgr的Cys17。 还提供了用于治疗感染，肿瘤和自身免疫性和炎性疾病的药物组合物和方法。 本发明还涉及一种将PEG部分逐步连接到多肽，更具体地涉及IFN-α的方法。
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4.发明授权Method for treating disorders and diseases treatable with human fibroblast interferon 有权治疗可用人成纤维细胞干扰素治疗的疾病和疾病的方法公开(公告)号：US07357925B2
公开(公告)日：2008-04-15
申请号：US10649609
申请日：2003-08-28
IPC分类号： A61K38/21
CPC分类号： A61K47/60 , Y10S514/825 , Y10S514/903
摘要： PEG-IFN-β conjugates, where a PEG moiety is covalently bound to Cys17 of human IFN-β, are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory diseases are also provided. The invention further relates to a method for the stepwise attachment of PEG moieties in series to a polypeptide, and more particularly to IFN-β.
摘要翻译： 其中PEG部分共价结合人IFN-β的Cys 17的PEG-IFN-β缀合物通过用硫醇反应性聚乙二醇化剂进行位点特异性PEG化的方法产生。 还提供了用于治疗感染，肿瘤和自身免疫性和炎性疾病的药物组合物和方法。 本发明还涉及将PEG部分逐步连接到多肽，更具体地说涉及IFN-β的方法。
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