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11 条记录 (耗时 0.014 秒)

    Antibodies binding 4-1BB and uses thereof
    3.
    发明授权
    Antibodies binding 4-1BB and uses thereof 有权

    公开(公告)号：US11466086B2

    公开(公告)日：2022-10-11

    申请号：US17038669

    申请日：2020-09-30

    申请人： Nanjing Leads Biolabs Co., Ltd.

    发明人： Xiaoqiang Kang ,  Xiao Huang ,  Jianming Sun

    IPC分类号： C07K16/00 ,  C07K16/28 ,  C07K16/30 ,  A61P35/00

    摘要： Disclosed is an isolated monoclonal antibody that specifically binds human 4-1BB, or the antigen-binding portion thereof. A nucleic acid molecule encoding the antibody, an expression vector, a host cell and a method for expressing the antibody are also provided. The present disclosure further provides a bispecific molecule, and a pharmaceutical composition comprising the antibody or the bispecific molecule, as well as a treatment method using an anti-4-1BB antibody of the disclosure.

    RECOMBINANT PROTEIN TARGETING PD-1 AND TGFβ
    4.
    发明申请
    RECOMBINANT PROTEIN TARGETING PD-1 AND TGFβ 有权

    公开(公告)号：US20210115142A1

    公开(公告)日：2021-04-22

    申请号：US17075212

    申请日：2020-10-20

    申请人： Nanjing Leads Biolabs Co., Ltd.

    发明人： Xiaoqiang Kang ,  Xiao Huang

    IPC分类号： C07K16/28 ,  C07K14/71 ,  A61P35/00

    摘要： A recombinant fusion protein comprising 1) TGFβR2, or a fragment thereof, capable of binding to TGFβ, and 2) an antibody, or an antigen-binding fragment thereof, that binds to PD-1. Also disclosed are a polynucleotide encoding the recombinant fusion protein, an expression vector containing the polynucleotide, a method for producing the recombinant protein and a method for treating a disease caused by over expression of TGFβ and/or PD-1 using the recombinant protein.