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1.发明授权Adsorbent for oral administration, and agent for treating or preventing renal or liver disease 有权用于口服的吸附剂和用于治疗或预防肾或肝脏疾病的药剂公开(公告)号：US08920796B2
公开(公告)日：2014-12-30
申请号：US10969998
申请日：2004-10-22
申请人： Naohiro Sonobe , Takashi Wakahoi
发明人： Naohiro Sonobe , Takashi Wakahoi
IPC分类号： A01N59/00 , A01N25/00 , A61K33/44 , A61K9/14 , A61K33/00 , A61K47/00 , B01J20/00 , C01B31/08
CPC分类号： A61K33/44 , Y10S514/893
摘要： An adsorbent for an oral administration, comprising a surface-modified spherical activated carbon wherein an average diameter is 0.01 to 1 mm, a specific surface area determined by a BET method is 700 m2/g or more, a volume of pores having a pore diameter of 7.5 to 15000 nm is from 0.25 mL/g to 1.0 mL/g, a total amount of acidic groups is 0.30 to 1.20 meq/g, and a total amount of basic groups is 0.20 to 0.7 meq/g, is disclosed.
摘要翻译： 一种用于口服给药的吸附剂，其包含平均直径为0.01至1mm的表面改性的球形活性炭，通过BET法测定的比表面积为700m 2 / g以上，具有孔径的孔的体积 7.5〜15000nm的范围为0.25mL / g〜1.0mL / g，酸性基团的总量为0.30〜1.20meq / g，碱性基团的总量为0.20〜0.7meq / g。
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2.发明授权Adsorbent for an oral administration, and agent for treating or preventing renal or liver disease 有权用于口服给药的吸附剂和用于治疗或预防肾或肝脏疾病的药剂公开(公告)号：US08440228B2
公开(公告)日：2013-05-14
申请号：US11547003
申请日：2005-04-04
申请人： Naohiro Sonobe , Takashi Wakahoi , Mieko Kuwahara
发明人： Naohiro Sonobe , Takashi Wakahoi , Mieko Kuwahara
摘要： An adsorbent for an oral administration, comprising a spherical activated carbon wherein an average particle diameter is 50 to 200 μm, a specific surface area determined by a BET method is 700 m2/g or more, and a bulk density is less than 0.54 g/mL is disclosed. The adsorbent for an oral administration has a high adsorbability, and is capable of adsorbing a large amount of toxins during a retention period in an intestine, and of remarkably increasing an adsorption amount of compounds having a large molecular weight.
摘要翻译： 用于口服给药的吸附剂，其包含平均粒径为50-200μm的球形活性炭，通过BET法测定的比表面积为700m 2 / g以上，堆积密度小于0.54g / mL。 用于口服的吸附剂具有高吸附性，并且能够在保留期间在肠中吸附大量的毒素，并且显着增加分子量大的化合物的吸附量。
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公开(公告)号：US20060159995A1
公开(公告)日：2006-07-20
申请号：US11378300
申请日：2006-03-20
申请人： Minoru Ishikawa , Kazuhiko Shimizu , Takashi Wakahoi , Shuji Morinishi , Naohiro Sonobe , Akio Hoshi
发明人： Minoru Ishikawa , Kazuhiko Shimizu , Takashi Wakahoi , Shuji Morinishi , Naohiro Sonobe , Akio Hoshi
CPC分类号： H01M4/583 , H01M4/02 , H01M4/364 , H01M4/38 , H01M4/46 , H01M10/052 , H01M2004/027
摘要： An electrode material comprising a powdery mixture of a metal material (particularly, an intermetallic compound) and a capacitive carbon material each capable of doping and dedoping lithium, and an optionally added fine electroconductive additive, and containing the metal material and the capacitive carbon material in amounts of 5-60 wt. % and 40-95 wt. %, respectively, is used as an active substance for an electrode, particularly a negative electrode, of a non-aqueous solvent secondary cell. As a result, there is provided a non-aqueous solvent secondary cell which has large charge-discharge capacities, a small irreversible capacity determined as a difference between the doping capacity and the de-doping capacity, and also excellent cycle characteristics.
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4.发明授权Adsorbent for an oral administration, and agent for treating or preventing renal or liver disease 有权用于口服给药的吸附剂和用于治疗或预防肾或肝脏疾病的药剂公开(公告)号：US08357366B2
公开(公告)日：2013-01-22
申请号：US11547043
申请日：2005-04-04
申请人： Naohiro Sonobe , Takashi Wakahoi , Mieko Kuwahara
发明人： Naohiro Sonobe , Takashi Wakahoi , Mieko Kuwahara
CPC分类号： A61K33/44 , Y10T428/2991
摘要： An adsorbent for an oral administration, comprising a surface-modified spherical activated carbon wherein an average particle diameter is 50 to 200 μm, a specific surface area determined by a BET method is 700 m2/g or more, a bulk density is less than 0.54 g/mL, a total amount of acidic groups is 0.30 to 1.20 meq/g, and a total amount of basic groups is 0.20 to 0.9 meq/g is disclosed. The adsorbent for an oral administration has a high adsorbability, and is capable of adsorbing a large amount of toxins during a retention period in an intestine, and of remarkably reducing an amount of urinary proteins excretion.
摘要翻译： 用于口服给药的吸附剂，其包含平均粒径为50〜200μm的表面改性的球形活性炭，BET法测定的比表面积为700m 2 / g以上，堆积密度小于0.54 g / mL，酸性基团的总量为0.30〜1.20meq / g，碱性基团的总量为0.20〜0.9meq / g。 用于口服的吸附剂具有高的吸附性，并且能够在保留期间在肠中吸附大量的毒素，并且显着减少尿蛋白排泄量。
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5.发明申请Adsorbent for oral administration, and agent for treating or preventing renal or liver disease 有权用于口服的吸附剂和用于治疗或预防肾或肝脏疾病的药剂公开(公告)号：US20050112114A1
公开(公告)日：2005-05-26
申请号：US10969998
申请日：2004-10-22
申请人： Naohiro Sonobe , Takashi Wakahoi
发明人： Naohiro Sonobe , Takashi Wakahoi
CPC分类号： A61K33/44 , Y10S514/893
摘要： An adsorbent for an oral administration, comprising a surface-modified spherical activated carbon wherein an average diameter is 0.01 to 1 mm, a specific surface area determined by a BET method is 700 m2/g or more, a volume of pores having a pore diameter of 7.5 to 15000 nm is from 0.25 mL/g to 1.0 mL/g, a total amount of acidic groups is 0.30 to 1.20 meq/g, and a total amount of basic groups is 0.20 to 0.7 meq/g, is disclosed.
摘要翻译： 一种用于口服给药的吸附剂，其包含平均直径为0.01至1mm的表面改性的球形活性炭，通过BET法测定的比表面积为700m 2 / g以上， 孔径为7.5〜15000nm的孔体积为0.25mL / g〜1.0mL / g，酸性基团的总量为0.30〜1.20meq / g，碱性基团的总量为0.20〜0.7 meq / g。
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6.发明授权Adsorbent for an oral administration, and agent for treating or preventing renal or liver disease 有权用于口服给药的吸附剂和用于治疗或预防肾或肝脏疾病的药剂公开(公告)号：US08865161B2
公开(公告)日：2014-10-21
申请号：US13490405
申请日：2012-06-06
申请人： Naohiro Sonobe , Takashi Wakahoi , Mieko Kuwahara
发明人： Naohiro Sonobe , Takashi Wakahoi , Mieko Kuwahara
CPC分类号： A61K33/44 , Y10T428/2991
摘要： An adsorbent for an oral administration, comprising a surface-modified spherical activated carbon wherein an average particle diameter is 50 to 200 μm, a specific surface area determined by a BET method is 700 m2/g or more, a bulk density is less than 0.54 g/mL, a total amount of acidic groups is 0.30 to 1.20 meq/g, and a total amount of basic groups is 0.20 to 0.9 meq/g is disclosed. The adsorbent for an oral administration has a high adsorbability, and is capable of adsorbing a large amount of toxins during a retention period in an intestine, and of remarkably reducing an amount of urinary proteins excretion.
摘要翻译： 用于口服给药的吸附剂，其包含平均粒径为50〜200μm的表面改性的球形活性炭，BET法测定的比表面积为700m 2 / g以上，堆积密度小于0.54 g / mL，酸性基团的总量为0.30〜1.20meq / g，碱性基团的总量为0.20〜0.9meq / g。 用于口服的吸附剂具有高的吸附性，并且能够在保留期间在肠中吸附大量的毒素，并且显着减少尿蛋白排泄量。
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7.发明申请Adsorbent for an Oral Administration, and Agent for Treating or Preventing Renal or Liver Disease 有权用于口服给药的吸附剂和用于治疗或预防肾脏或肝脏疾病的药剂公开(公告)号：US20080081073A1
公开(公告)日：2008-04-03
申请号：US11547043
申请日：2005-04-04
申请人： Naohiro Sonobe , Takashi Wakahoi , Mieko Kuwahara
发明人： Naohiro Sonobe , Takashi Wakahoi , Mieko Kuwahara
CPC分类号： A61K33/44 , Y10T428/2991
摘要： An adsorbent for an oral administration, comprising a surface-modified spherical activated carbon wherein an average particle diameter is 50 to 200 μm, a specific surface area determined by a BET method is 700 m2/g or more, a bulk density is less than 0.54 g/mL, a total amount of acidic groups is 0.30 to 1.20 meq/g, and a total amount of basic groups is 0.20 to 0.9 meq/g is disclosed. The adsorbent for an oral administration has a high adsorbability, and is capable of adsorbing a large amount of toxins during a retention period in an intestine, and of remarkably reducing an amount of urinary proteins excretion.
摘要翻译： 一种用于口服给药的吸附剂，其包含平均粒径为50至200μm的表面改性的球形活性炭，通过BET法测定的比表面积为700m 2 / g以上 ，堆积密度小于0.54g / mL，酸性基团的总量为0.30〜1.20meq / g，碱性基团的总量为0.20〜0.9meq / g。 用于口服的吸附剂具有高的吸附性，并且能够在保留期间在肠中吸附大量的毒素，并且显着减少尿蛋白排泄量。
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公开(公告)号：US20080031972A1
公开(公告)日：2008-02-07
申请号：US11547501
申请日：2005-04-04
申请人： Naohiro Sonobe , Takashi Wakahoi , Mieko Kuwahara , Hiroshi Ohta
发明人： Naohiro Sonobe , Takashi Wakahoi , Mieko Kuwahara , Hiroshi Ohta
CPC分类号： A61K33/44 , C01B32/336 , C01P2004/60 , C01P2004/61 , C01P2006/12 , C01P2006/14
摘要： A process for manufacturing a spherical activated carbon, characterized by comprising the steps of: (1) forming a spherical substance of a heat-fusible resin, (2) oxidizing the spherical substance of a heat-fusible resin to form a heat-infusible spherical substance, and (3) activating the heat-infusible spherical substance to form the spherical activated carbon is disclosed. According to the process for the manufacture, a spherical activated carbon having desirable properties, such as an average particle diameter, a particle size distribution, a pore volume, or a specific surface area, can be easily prepared.
摘要翻译： 一种制造球形活性炭的方法，其特征在于包括以下步骤：（1）形成热熔性树脂的球形物质，（2）将可热熔树脂的球形物质氧化以形成热熔融球形 物质，和（3）激活热不熔球形成球形活性炭。 根据制造方法，可以容易地制备具有所需性质如平均粒径，粒度分布，孔体积或比表面积的球形活性炭。
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9.发明申请ADSORBENT FOR AN ORAL ADMINISTRATION, AND AGENT FOR TREATING OR PREVENTING RENAL OR LIVER DISEASE 有权口服药物的治疗方法及治疗或预防肝炎或肝病的药剂公开(公告)号：US20120244195A1
公开(公告)日：2012-09-27
申请号：US13490405
申请日：2012-06-06
申请人： Naohiro Sonobe , Takashi Wakahoi , Mieko Kuwahara
发明人： Naohiro Sonobe , Takashi Wakahoi , Mieko Kuwahara
CPC分类号： A61K33/44 , Y10T428/2991
摘要： An adsorbent for an oral administration, comprising a surface-modified spherical activated carbon wherein an average particle diameter is 50 to 200 μm, a specific surface area determined by a BET method is 700 m2/g or more, a bulk density is less than 0.54 g/mL, a total amount of acidic groups is 0.30 to 1.20 meq/g, and a total amount of basic groups is 0.20 to 0.9 meq/g is disclosed. The adsorbent for an oral administration has a high adsorbability, and is capable of adsorbing a large amount of toxins during a retention period in an intestine, and of remarkably reducing an amount of urinary proteins excretion.
摘要翻译： 用于口服给药的吸附剂，其包含平均粒径为50〜200μm的表面改性的球形活性炭，BET法测定的比表面积为700m 2 / g以上，堆积密度小于0.54 g / mL，酸性基团的总量为0.30〜1.20meq / g，碱性基团的总量为0.20〜0.9meq / g。 用于口服的吸附剂具有高的吸附性，并且能够在保留期间在肠中吸附大量的毒素，并且显着减少尿蛋白排泄量。
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10.发明申请Adsorbent for an Oral Administration, and Agent for Treating or Preventing Renal or Liver Disease 有权用于口服给药的吸附剂和用于治疗或预防肾脏或肝脏疾病的药剂公开(公告)号：US20080044477A1
公开(公告)日：2008-02-21
申请号：US11547003
申请日：2005-04-04
申请人： Naohiro Sonobe , Takashi Wakahoi , Mieko Kuwahara
发明人： Naohiro Sonobe , Takashi Wakahoi , Mieko Kuwahara
摘要： An adsorbent for an oral administration, comprising a spherical activated carbon wherein an average particle diameter is 50 to 200 μm, a specific surface area determined by a BET method is 700 m2/g or more, and a bulk density is less than 0.54 g/mL is disclosed. The adsorbent for an oral administration has a high adsorbability, and is capable of adsorbing a large amount of toxins during a retention period in an intestine, and of remarkably increasing an adsorption amount of compounds having a large molecular weight.
摘要翻译： 一种口服吸收剂，其包含平均粒径为50〜200μm的球形活性炭，BET法测定的比表面积为700m 2 / g以上， 公开了堆密度小于0.54g / mL。 用于口服的吸附剂具有高吸附性，并且能够在保留期间在肠中吸附大量的毒素，并且显着增加分子量大的化合物的吸附量。
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