公开(公告)号：US08865161B2

公开(公告)日：2014-10-21

申请号：US13490405

申请日：2012-06-06

Applicant: Naohiro Sonobe ,  Takashi Wakahoi ,  Mieko Kuwahara

Inventor： Naohiro Sonobe ,  Takashi Wakahoi ,  Mieko Kuwahara

IPC: A61K33/44 ,  A61K9/14

CPC classification number: A61K33/44 ,  Y10T428/2991

Abstract: An adsorbent for an oral administration, comprising a surface-modified spherical activated carbon wherein an average particle diameter is 50 to 200 μm, a specific surface area determined by a BET method is 700 m2/g or more, a bulk density is less than 0.54 g/mL, a total amount of acidic groups is 0.30 to 1.20 meq/g, and a total amount of basic groups is 0.20 to 0.9 meq/g is disclosed. The adsorbent for an oral administration has a high adsorbability, and is capable of adsorbing a large amount of toxins during a retention period in an intestine, and of remarkably reducing an amount of urinary proteins excretion.

Abstract translation: 用于口服给药的吸附剂，其包含平均粒径为50〜200μm的表面改性的球形活性炭，BET法测定的比表面积为700m 2 / g以上，堆积密度小于0.54 g / mL，酸性基团的总量为0.30〜1.20meq / g，碱性基团的总量为0.20〜0.9meq / g。 用于口服的吸附剂具有高的吸附性，并且能够在保留期间在肠中吸附大量的毒素，并且显着减少尿蛋白排泄量。

公开(公告)号：US20100074954A1

公开(公告)日：2010-03-25

申请号：US12630581

申请日：2009-12-03

Applicant: Naohiro Sonobe ,  Susumu Morimoto ,  Hideyuki Yoshihara ,  Hiroyuki Hanatsuka ,  Makoto Arakawa

Inventor： Naohiro Sonobe ,  Susumu Morimoto ,  Hideyuki Yoshihara ,  Hiroyuki Hanatsuka ,  Makoto Arakawa

IPC: A61K9/18 ,  A61K33/44 ,  A61P1/16 ,  A61P13/12

CPC classification number: A61K33/44

Abstract: An adsorbent for oral administration, characterized by comprising a spherical activated carbon, wherein a diameter is 0.01 to 1 mm, a specific surface area determined by Langmuir's adsorption equation is 1000 m2/g or more, and a diffraction intensity ratio, an R value, determined by an equation (1): R=(I15−I35)/(I24−I35)  (1) wherein I15 is a diffraction intensity when a diffraction angle (2θ) of an X-ray diffractometry is 15°, I35 is a diffraction intensity when a diffraction angle (2θ) of an X-ray diffractometry is 35°, and I24 is a diffraction intensity when a diffraction angle (2θ) of an X-ray diffractometry is 24°, is 1.4 or more; and an adsorbent for an oral administration, characterized by comprising a surface-modified spherical activated carbon, wherein a diameter is 0.01 to 1 mm, a specific surface area determined by Langmuir's adsorption equation is 1000 m2/g or more, a total amount of acidic groups is 0.40 to 1.00 meq/g, a total amount of basic groups is 0.40 to 1.10 meq/g, and a diffraction intensity ratio, an R value, determined by equation (1) is 1.4 or more. The adsorbents for oral administration exhibit a useful selective adsorbability, that is, a less adsorbability of useful substances in a body, and a greater adsorbability of toxic substances.

Abstract translation: 一种用于口服给药的吸附剂，其特征在于包含球形活性炭，其直径为0.01至1mm，由Langmuir吸附方程确定的比表面积为1000m 2 / g以上，衍射强度比R值， 由式（1）确定：R =（I15-I35）/（I24-I35）（1）其中I15是当X射线衍射的衍射角（2θ）为15°时的衍射强度，I35为 X射线衍射的衍射角（2θ）为35°时的衍射强度，I24为X射线衍射的衍射角（2θ）为24°时的衍射强度为1.4以上。 和口服给药用吸附剂，其特征在于，包含直径为0.01〜1mm的表面改性球形活性炭，朗缪尔吸附方程式测定的比表面积为1000m 2 / g以上，酸性总量 基团的总量为0.40〜1.00meq / g，碱性基团的总量为0.40〜1.10meq / g，衍生强度比，R值由式（1）确定为1.4以上。 用于口服给药的吸附剂表现出有用的选择性吸附性，即有用物质在体内的吸附性较差，并且有毒物质的吸附性更高。

公开(公告)号：US07634840B2

公开(公告)日：2009-12-22

申请号：US10582866

申请日：2004-12-14

Applicant: Tatsuo Kobayashi ,  Naohiro Sonobe

Inventor： Tatsuo Kobayashi ,  Naohiro Sonobe

IPC: D01G27/00

CPC classification number: D01G15/68

Abstract: A pitch-based carbon fiber sliver providing a high-strength carbon fiber spun yarn is efficiently produced by providing a pitch-based carbon fiber mat comprising a mass of piled-up pitch-based carbon fibers of which fiber extension directions are aligned preferentially in one direction; and directly subjecting the carbon fiber mat to drawing and carding by means of a carding machine while moving the mat in said one preferential alignment direction. The thus-obtained carbon fiber sliver is drawn and twisted to produce a pitch-based carbon fiber spun yarn containing at least 3 wt. % of fibers having a fiber length of at least 150 mm, a number of primary twist of 50-400 turns/m and a tensile strength of at least 0.10 N/tex.

Abstract translation: 提供高强度碳纤维短纤纱的沥青基碳纤维条通过提供一种基于沥青的碳纤维垫而有效地制成，所述沥青基碳纤维垫包括一堆堆积的沥青类碳纤维，其纤维延伸方向优先于一个 方向; 并且通过梳理机直接对碳纤维毡进行拉伸和梳理，同时沿所述一个优先排列方向移动垫子。 将如此获得的碳纤维纱线拉伸和扭曲，以生产含有至少3重量％ 纤维长度至少为150mm，初捻为50-400匝/ m，拉伸强度为至少0.10N / tex的纤维的％。

公开(公告)号：US07610743B2

公开(公告)日：2009-11-03

申请号：US10581254

申请日：2004-11-30

Applicant: Tatsuo Kobayashi ,  Naohiro Sonobe

Inventor： Tatsuo Kobayashi ,  Naohiro Sonobe

IPC: D02G3/02

CPC classification number: D02G3/16 ,  D02G3/447 ,  D03D15/00 ,  D10B2101/12 ,  D10B2201/24 ,  D10B2321/10 ,  D10B2401/063 ,  D10B2401/16 ,  Y10T442/3065

Abstract: A carbon fiber spun yarn, which is a spun yarn of a carbon fiber that has an average (002)-interlayer spacing of 0.340-0.380 nm as measured by X-ray diffraction method, has a specific gravity of 1.55-1.80 as measured by a density gradient tube method, a hydrogen-to carbon atomic ratio (H/C) as measured by elementary analysis of at most 0.1 and contains 3-30 wt. % of carbon fiber having a fiber length of at least 150 mm, wherein the spun yarn has a weight per 1000 m (tex) of 30-150 g, a number of primary twist of 50-400 turns/m and a tensile strength of at least 0.15 N/tex. The carbon fiber spun yarn may be woven to provide a carbon fiber woven fabric suitable as a gas diffuser (electroconductive substrate) of a solid polymer electrolyte fuel cell.

Abstract translation: 作为通过X射线衍射法测定的平均（002） - 间隔间隔为0.340〜3.80nm的碳纤维的短纤纱的碳纤维纱线，其比重为1.55〜1.80，通过 密度梯度管法，通过元素分析测量的至多0.1的氢 - 碳原子比（H / C），含有3-30wt。 纤维长度至少为150mm的碳纤维的％，其中，所述纺织纱线的每1000m（tex）的重量为30〜150g，初捻为50-400匝/ m，拉伸强度为 至少0.15N / tex。 可以将碳纤维短纤维织物编织，以提供适合作为固体聚合物电解质燃料电池的气体扩散器（导电基材）的碳纤维织物。

公开(公告)号：US20090140214A1

公开(公告)日：2009-06-04

申请号：US10583762

申请日：2005-03-25

Applicant: Naohiro Sonobe ,  Hiroshi Ohta ,  Takahiro Akita

Inventor： Naohiro Sonobe ,  Hiroshi Ohta ,  Takahiro Akita

IPC: H01B1/04

CPC classification number: H01M10/052 ,  C01B32/05 ,  H01M4/131 ,  H01M4/133 ,  H01M4/587 ,  H01M10/0525 ,  H01M2004/021

Abstract: A negative electrode material for non-aqueous electrolyte secondary batteries, comprises: a carbon material having a sphericity of at least 0.8, and exhibiting an average (002) interlayer spacing d002 of 0.365-0.400 nm, a crystallite size in a c-axis direction Lc(002) of 1.0-3.0 nm, as measured by X-ray diffractometry, a hydrogen-to-carbon atomic ratio (H/C) of at most 0.1 as measured by elementary analysis, and an average particle size Dv50 of 1-20 μm. The negative electrode material is spherical and exhibits excellent performances including high output performance and durability.

Abstract translation: 一种非水电解质二次电池用负极材料，其特征在于，具有：球形度为0.8以上，并且平均（002）层间距d002为0.365-0.400nm，c轴方向的微晶尺寸 通过X射线衍射法测定的1.0〜3.0nm的Lc（002），通过元素分析测定的氢碳原子比（H / C）为0.1以下，平均粒径Dv50为1- 20个妈妈 负极材料是球形的并且具有优异的性能，包括高输出性能和耐久性。

公开(公告)号：US20080081073A1

公开(公告)日：2008-04-03

申请号：US11547043

申请日：2005-04-04

Applicant: Naohiro Sonobe ,  Takashi Wakahoi ,  Mieko Kuwahara

Inventor： Naohiro Sonobe ,  Takashi Wakahoi ,  Mieko Kuwahara

IPC: A61K9/14 ,  A61K33/00 ,  A61P1/16 ,  A61P13/12

CPC classification number: A61K33/44 ,  Y10T428/2991

Abstract: An adsorbent for an oral administration, comprising a surface-modified spherical activated carbon wherein an average particle diameter is 50 to 200 μm, a specific surface area determined by a BET method is 700 m2/g or more, a bulk density is less than 0.54 g/mL, a total amount of acidic groups is 0.30 to 1.20 meq/g, and a total amount of basic groups is 0.20 to 0.9 meq/g is disclosed. The adsorbent for an oral administration has a high adsorbability, and is capable of adsorbing a large amount of toxins during a retention period in an intestine, and of remarkably reducing an amount of urinary proteins excretion.

Abstract translation: 一种用于口服给药的吸附剂，其包含平均粒径为50至200μm的表面改性的球形活性炭，通过BET法测定的比表面积为700m 2 / g以上 ，堆积密度小于0.54g / mL，酸性基团的总量为0.30〜1.20meq / g，碱性基团的总量为0.20〜0.9meq / g。 用于口服的吸附剂具有高的吸附性，并且能够在保留期间在肠中吸附大量的毒素，并且显着减少尿蛋白排泄量。

公开(公告)号：US20080031972A1

公开(公告)日：2008-02-07

申请号：US11547501

申请日：2005-04-04

Applicant: Naohiro Sonobe ,  Takashi Wakahoi ,  Mieko Kuwahara ,  Hiroshi Ohta

Inventor： Naohiro Sonobe ,  Takashi Wakahoi ,  Mieko Kuwahara ,  Hiroshi Ohta

IPC: A61K33/44 ,  C01B31/02

CPC classification number: A61K33/44 ,  C01B32/336 ,  C01P2004/60 ,  C01P2004/61 ,  C01P2006/12 ,  C01P2006/14

Abstract: A process for manufacturing a spherical activated carbon, characterized by comprising the steps of: (1) forming a spherical substance of a heat-fusible resin, (2) oxidizing the spherical substance of a heat-fusible resin to form a heat-infusible spherical substance, and (3) activating the heat-infusible spherical substance to form the spherical activated carbon is disclosed. According to the process for the manufacture, a spherical activated carbon having desirable properties, such as an average particle diameter, a particle size distribution, a pore volume, or a specific surface area, can be easily prepared.

Abstract translation: 一种制造球形活性炭的方法，其特征在于包括以下步骤：（1）形成热熔性树脂的球形物质，（2）将可热熔树脂的球形物质氧化以形成热熔融球形 物质，和（3）激活热不熔球形成球形活性炭。 根据制造方法，可以容易地制备具有所需性质如平均粒径，粒度分布，孔体积或比表面积的球形活性炭。

公开(公告)号：US20050069481A1

公开(公告)日：2005-03-31

申请号：US10948302

申请日：2004-09-24

Applicant: Naohiro Sonobe ,  Ikuo Seo

Inventor： Naohiro Sonobe ,  Ikuo Seo

IPC: C01B31/08 ,  C01B31/10 ,  C10C3/04 ,  C01D3/00

CPC classification number: C10C3/04 ,  C01B32/382

Abstract: A spherical activated carbon is produced from a starting pitch obtainable from a heavy hydrocarbon oil, such as petroleum tar, coal tar or ethylene, through a moderate process. The starting pitch has a softening point of at least 150° C., a toluene-insoluble content of at least 40% and a property of retaining optical isotropy even after being heated at 430° C. for 1 hour. The starting pitch is converted into a porous spherical pitch, which is then infusibilized, carbonized and activated to provide a spherical activated carbon.

Abstract translation: 球形活性炭通过中等程度从可得自重质烃油如石油焦油，煤焦油或乙烯的起始沥青产生。 起始沥青的软化点至少为150℃，甲苯不溶物含量至少为40％，即使在430℃加热1小时后也保持光学各向同性。 起始沥青转化为多孔球形沥青，然后将其熔融，碳化并活化以提供球形活性炭。

公开(公告)号：US5741472A

公开(公告)日：1998-04-21

申请号：US518357

申请日：1995-08-23

Applicant: Naohiro Sonobe ,  Jiro Masuko ,  Takao Iwasaki

Inventor： Naohiro Sonobe ,  Jiro Masuko ,  Takao Iwasaki

IPC: C01B31/00 ,  H01M4/133 ,  H01M4/58 ,  H01M4/587 ,  H01M10/052 ,  H01M10/36 ,  C09C1/56

CPC classification number: H01M4/133 ,  C01B31/005 ,  H01M4/587 ,  H01M10/052

Abstract: A carbonaceous electrode having improved capacities for doping and dedoping of a cell active substance, such as lithium, and suitable for a non-aqueous solvent-type secondary battery, is constituted by a carbonaceous material having a specific microtexture. The carbonaceous material is characterized by an average (002)-plane spacing of at least 0.365 nm according to X-ray diffraction method, and also a ratio .rho..sub.H /.rho..sub.B of at least 1.15 wherein .rho..sub.H denotes a density measured by using helium gas as a substitution medium and .rho..sub.B denotes a density measured by using butanol as a substitution medium.

Abstract translation: 具有改善的电池活性物质（例如锂）的掺杂和脱掺杂性并且适用于非水溶剂型二次电池的碳质电极由具有特定微结构的碳质材料构成。 碳质材料的特征在于根据X射线衍射法的至少0.365nm的平均（002）面间距，并且rho H / rho B的比值至少为1.15，其中rho H表示通过使用氦测量的密度 气体作为取代介质，rho B表示通过使用丁醇作为取代介质测定的密度。

公开(公告)号：US5616436A

公开(公告)日：1997-04-01

申请号：US518306

申请日：1995-08-23

Applicant: Naohiro Sonobe ,  Minoru Ishikawa ,  Takao Iwasaki

Inventor： Naohiro Sonobe ,  Minoru Ishikawa ,  Takao Iwasaki

IPC: C01B31/02 ,  B82Y30/00 ,  B82Y99/00 ,  H01M4/583 ,  H01M6/10 ,  H01M10/05 ,  H01M4/04 ,  H01M4/36 ,  H01M4/58

CPC classification number: H01M4/133 ,  H01M10/052 ,  H01M4/587 ,  H01M2004/027 ,  H01M6/10

Abstract: A carbonaceous electrode having improved capacities for doping and dedoping of a cell active substance, such as lithium, and suitable for a non-aqueous solvent-type secondary battery, is constituted by a carbonaceous material having a specific microtexture. The carbonaceous material is characterized by it's ability to provide an electrochemically lithium-doped product showing a main resonance peak which is shifted by 80-200 ppm to a lower magnetic field side from a resonance line of LiCl as a reference substance when subjected to .sup.7 Li-NMR spectroscopy analysis.

Abstract translation: 具有改善的电池活性物质（例如锂）的掺杂和去掺杂的适用于非水溶剂型二次电池的碳质电极由具有特定微结构的碳质材料构成。 碳质材料的特征在于能够提供一种电化学锂掺杂产物，其表现出主谐振峰，当主要谐振峰经受7Li-1时，主谐振峰从作为对照物质的LiCl的共振线偏移到较低的磁场侧， NMR光谱分析。