公开(公告)号：US06682718B1

公开(公告)日：2004-01-27

申请号：US10130795

申请日：2002-05-23

申请人： Naoto O'Uchi ,  Takaya Iwai ,  Taiji Yoshino ,  Hiroyuki Kanoh ,  Hiroyuki Motoie

发明人： Naoto O'Uchi ,  Takaya Iwai ,  Taiji Yoshino ,  Hiroyuki Kanoh ,  Hiroyuki Motoie

IPC分类号： A61K716

CPC分类号： A61K31/663 ,  A61K9/0063

摘要： The invention relates to an alveolar bone resorption inhibitor for use in topical injection by an alveolar mucosa injection method, which comprises a bisphosphonic acid derivative or a salt thereof as an active ingredient and to an alveolar bone resorption inhibitor for human periodontal tissue topical injection, which comprises a bisphosphonic acid derivative or a salt thereof in a concentration small enough so that local irritation to human periodontal tissues as the administrating site is acceptable but sufficient enough for expressing alveolar bone resorption inhibitory action by topical injection.

摘要翻译： 本发明涉及通过肺泡粘膜注射方法局部注射的牙槽骨吸收抑制剂，其包含双膦酸衍生物或其盐作为活性成分，以及用于人牙周组织局部注射的牙槽骨吸收抑制剂，其中 包含足够浓度的二膦酸衍生物或其盐，使得作为给药部位的人牙周组织的局部刺激是可接受的，但足够足以通过局部注射表达牙槽骨吸收抑制作用。

公开(公告)号：US20060173009A1

公开(公告)日：2006-08-03

申请号：US10563107

申请日：2004-06-30

申请人： Hiroyuki Kanoh ,  Koichiro Takahashi ,  Hiromi Nara ,  Tatsuhiko Yamanoi ,  Shinji Fukushima ,  Ryo Naito ,  Susumu Igarashi

发明人： Hiroyuki Kanoh ,  Koichiro Takahashi ,  Hiromi Nara ,  Tatsuhiko Yamanoi ,  Shinji Fukushima ,  Ryo Naito ,  Susumu Igarashi

IPC分类号： A61K31/503

CPC分类号： A61K31/5025 ,  A61K31/662 ,  A61K31/663 ,  A61K2300/00

摘要： Osteoporosis and the like metabolic bone diseases have a high frequency of causing lumbago and the like pains and bone fracture, due to lowering of the bone strength caused by the reduction of bone mass. Accordingly, great concern has been directed toward the creation of a drug which can increase the bone mass and bone strength by controlling the whole bone metabolism. The pharmaceutical composition or combination product of the invention comprising a non-living body-derived non-peptide osteoblast differentiation promoting compound and a bisphosphonate having a bone resorption inhibitory action is useful as a bone mass increasing inducer which can increase the bone mass and/or bone strength by controlling the bone metabolism.

摘要翻译： 骨质疏松等代谢性骨疾病由于骨质量下降引起的骨强度降低，频繁地引起腰痛等骨折。 因此，非常关注通过控制整个骨代谢来增加骨量和骨强度的药物的产生。 包含非生物体衍生的非肽成骨细胞分化促进化合物和具有骨吸收抑制作用的二膦酸盐的本发明的药物组合物或组合产品可用作骨质量增加诱导剂，其可以增加骨量和/或 通过控制骨骼代谢的骨骼力量。

公开(公告)号：US20050096322A1

公开(公告)日：2005-05-05

申请号：US10505939

申请日：2003-02-27

申请人： Susumu Igarashi ,  Ryo Naito ,  Yoshinori Okamoto ,  Noriyuki Kawano ,  Issei Tsukamoto ,  Ippei Sato ,  Makoto Takeuchi ,  Hiroyuki Kanoh ,  Masato Kobori

发明人： Susumu Igarashi ,  Ryo Naito ,  Yoshinori Okamoto ,  Noriyuki Kawano ,  Issei Tsukamoto ,  Ippei Sato ,  Makoto Takeuchi ,  Hiroyuki Kanoh ,  Masato Kobori

IPC分类号： A61P19/00 ,  A61P19/08 ,  A61P19/10 ,  A61P43/00 ,  C07D487/04 ,  A61K31/503

CPC分类号： C07D487/04

摘要： As a result of an effort made by us for the purpose of developing a therapeutic agent having a bone formation-stimulating effect by promoting the functions of osteoblasts, the present inventors discovered that a certain nitrogen-containing heterocyclic compound exhibits a potent bone formation-stimulating effect on the osteoblast and thus can serve as an excellent prophylactic or therapeutic agent against a metabolic bone disease, whereby establishing the present invention. Thus, the present invention provides a 3,6-disubstituted 1,2,4-triazolo[4,3-b]pyridazine compound or a pharmaceutically acceptable salt thereof as well as a pharmaceutical composition comprising such a compound and a pharmaceutically acceptable carrier, especially a bone-forming agent.

摘要翻译： 本发明人为了通过促进成骨细胞的功能开发具有促进骨形成刺激作用的治疗剂而作出努力的结果，发现某些含氮杂环化合物表现出强有力的骨形成刺激 对成骨细胞的作用，因此可以作为抗代谢性骨病的优异的预防或治疗剂，由此建立本发明。 因此，本发明提供了3,6-二取代的1,2,4-三唑并[4,3-b]哒嗪化合物或其药学上可接受的盐，以及包含这种化合物和药学上可接受的载体的药物组合物， 特别是骨形成剂。

公开(公告)号：US07173033B2

公开(公告)日：2007-02-06

申请号：US11190859

申请日：2005-07-28

申请人： Susumu Igarashi ,  Ryo Naito ,  Yoshinori Okamoto ,  Noriyuki Kawano ,  Issei Tsukamoto ,  Ippei Sato ,  Makoto Takeuchi ,  Hiroyuki Kanoh ,  Masato Kobori

发明人： Susumu Igarashi ,  Ryo Naito ,  Yoshinori Okamoto ,  Noriyuki Kawano ,  Issei Tsukamoto ,  Ippei Sato ,  Makoto Takeuchi ,  Hiroyuki Kanoh ,  Masato Kobori

IPC分类号： C07D487/04 ,  A61K31/5025 ,  A61P19/08

CPC分类号： C07D487/04

摘要： As a result of an effort made by us for the purpose of developing a therapeutic agent having a bone formation-stimulating effect by promoting the functions of osteoblasts, the present inventors discovered that a certain nitrogen-containing heterocyclic compound exhibits a potent bone formation-stimulating effect on the osteoblast and thus can serve as an excellent prophylactic or therapeutic agent against a metabolic bone disease, whereby establishing the present invention.Thus, the present invention provides a 3,6-disubstituted 1,2,4-triazolo[4,3-b]pyridazine compound or a pharmaceutically acceptable salt thereof as well as a pharmaceutical composition comprising such a compound and a pharmaceutically acceptable carrier, especially a bone-forming agent.

摘要翻译： 本发明人为了通过促进成骨细胞的功能开发具有促进骨形成刺激作用的治疗剂而作出努力的结果，发现某些含氮杂环化合物表现出强有力的骨形成刺激 对成骨细胞的作用，因此可以作为抗代谢性骨病的优异的预防或治疗剂，由此建立本发明。 因此，本发明提供了3,6-二取代的1,2,4-三唑并[4,3-b]哒嗪化合物或其药学上可接受的盐，以及包含这种化合物和药学上可接受的载体的药物组合物， 特别是骨形成剂。

公开(公告)号：US20050261297A1

公开(公告)日：2005-11-24

申请号：US11190859

申请日：2005-07-28

申请人： Susumu Igarashi ,  Ryo Naito ,  Yoshinori Okamoto ,  Noriyuki Kawano ,  Issei Tsukamoto ,  Ippei Sato ,  Makoto Takeuchi ,  Hiroyuki Kanoh ,  Masato Kobori

发明人： Susumu Igarashi ,  Ryo Naito ,  Yoshinori Okamoto ,  Noriyuki Kawano ,  Issei Tsukamoto ,  Ippei Sato ,  Makoto Takeuchi ,  Hiroyuki Kanoh ,  Masato Kobori

IPC分类号： A61P19/00 ,  A61P19/08 ,  A61P19/10 ,  A61P43/00 ,  C07D487/04 ,  A61K31/503 ,  A61K31/55

CPC分类号： C07D487/04

摘要： As a result of an effort made by us for the purpose of developing a therapeutic agent having a bone formation-stimulating effect by promoting the functions of osteoblasts, the present inventors discovered that a certain nitrogen-containing heterocyclic compound exhibits a potent bone formation-stimulating effect on the osteoblast and thus can serve as an excellent prophylactic or therapeutic agent against a metabolic bone disease, whereby establishing the present invention. Thus, the present invention provides a 3,6-disubstituted 1,2,4-triazolo[4,3-b]pyridazine compound or a pharmaceutically acceptable salt thereof as well as a pharmaceutical composition comprising such a compound and a pharmaceutically acceptable carrier, especially a bone-forming agent.

公开(公告)号：US5920174A

公开(公告)日：1999-07-06

申请号：US656329

申请日：1996-06-14

申请人： Hideaki Kawada ,  Hiroyuki Kanoh ,  Hisayoshi Koiwai ,  Syuji Endo ,  Yoshinori Sugiyama ,  Yuji Kouzaki

发明人： Hideaki Kawada ,  Hiroyuki Kanoh ,  Hisayoshi Koiwai ,  Syuji Endo ,  Yoshinori Sugiyama ,  Yuji Kouzaki

IPC分类号： B62D5/04

CPC分类号： B62D5/049

摘要： A control apparatus of an electric power steering apparatus capable of firmly detecting an abnormality of a torque detection value, caused by a drift occurred in a torque sensor and by a connector contact resistor, with a simple arrangement. A current supplied from a power supply flows through a potentiometer (3A) of a torque sensor (3), this current is supplied to a current detecting resistor (13g), a drift occurred in the torque sensor (3) is detected by a voltage across terminals of this resistor, the detected drift detection voltage V.sub.is is read in a microcomputer (21), and the drift detection voltage V.sub.is is compared with a set value to judge as to whether or not the drift is present within a normal range. The torque sensor is constructed of a main potentiometer (3.sub.M) and a sub-potentiometer (3.sub.S). A change amount .DELTA.V.sub.M is calculated from a difference between a presently detected value and a previously detected value of the torque detection voltage V.sub.2M of the main potentiometer. Also, a change amount .DELTA.V.sub.S as to the sub-potentiometer is similarly calculated. An abnormality of the torque detection value is judged in response to these change amounts .DELTA.V.sub.M and .DELTA.V.sub.S.

摘要翻译： PCT No.PCT / JP95 / 02098 Sec。 371日期1996年6月14日第 102（e）日期1996年6月14日PCT提交1995年10月13日PCT公布。 公开号WO96 / 11831 日期：1996年04月25日一种电动助力转向装置的控制装置，能够通过简单的布置牢固地检测由转矩传感器和连接器接触电阻器发生的漂移引起的转矩检测值的异常。 从电源供给的电流流过转矩传感器（3）的电位计（3A），该电流被提供给电流检测电阻（13g），转矩传感器（3）中发生的漂移被电压 在该电阻器的两端，检测到的漂移检测电压Vis被读入微型计算机（21），并将漂移检测电压Vis与设定值进行比较，以判断漂移是否存在于正常范围内。 扭矩传感器由主电位器（3M）和副电位器（3S）构成。 根据当前检测值与主电位计的转矩检测电压V2M的先前检测值的差计算变化量DELTA VM。 此外，类似地计算关于副电位计的变化量DELTA VS。 根据这些变化量DELTA VM和DELTA VS来判断转矩检测值的异常。