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    Nitrogen-containing heterocyclic compound
    1.
    发明申请
    Nitrogen-containing heterocyclic compound 审中-公开
    含氮杂环化合物

    公开(公告)号：US20050096322A1

    公开(公告)日：2005-05-05

    申请号：US10505939

    申请日：2003-02-27

    申请人： Susumu Igarashi ,  Ryo Naito ,  Yoshinori Okamoto ,  Noriyuki Kawano ,  Issei Tsukamoto ,  Ippei Sato ,  Makoto Takeuchi ,  Hiroyuki Kanoh ,  Masato Kobori

    发明人： Susumu Igarashi ,  Ryo Naito ,  Yoshinori Okamoto ,  Noriyuki Kawano ,  Issei Tsukamoto ,  Ippei Sato ,  Makoto Takeuchi ,  Hiroyuki Kanoh ,  Masato Kobori

    IPC分类号： A61P19/00 ,  A61P19/08 ,  A61P19/10 ,  A61P43/00 ,  C07D487/04 ,  A61K31/503

    CPC分类号： C07D487/04

    摘要： As a result of an effort made by us for the purpose of developing a therapeutic agent having a bone formation-stimulating effect by promoting the functions of osteoblasts, the present inventors discovered that a certain nitrogen-containing heterocyclic compound exhibits a potent bone formation-stimulating effect on the osteoblast and thus can serve as an excellent prophylactic or therapeutic agent against a metabolic bone disease, whereby establishing the present invention. Thus, the present invention provides a 3,6-disubstituted 1,2,4-triazolo[4,3-b]pyridazine compound or a pharmaceutically acceptable salt thereof as well as a pharmaceutical composition comprising such a compound and a pharmaceutically acceptable carrier, especially a bone-forming agent.

    摘要翻译： 本发明人为了通过促进成骨细胞的功能开发具有促进骨形成刺激作用的治疗剂而作出努力的结果，发现某些含氮杂环化合物表现出强有力的骨形成刺激 对成骨细胞的作用，因此可以作为抗代谢性骨病的优异的预防或治疗剂，由此建立本发明。 因此，本发明提供了3,6-二取代的1,2,4-三唑并[4,3-b]哒嗪化合物或其药学上可接受的盐，以及包含这种化合物和药学上可接受的载体的药物组合物， 特别是骨形成剂。

    Nitrogen-containing heterocyclic compound
    2.
    发明授权
    Nitrogen-containing heterocyclic compound 失效
    含氮杂环化合物

    公开(公告)号：US07173033B2

    公开(公告)日：2007-02-06

    申请号：US11190859

    申请日：2005-07-28

    申请人： Susumu Igarashi ,  Ryo Naito ,  Yoshinori Okamoto ,  Noriyuki Kawano ,  Issei Tsukamoto ,  Ippei Sato ,  Makoto Takeuchi ,  Hiroyuki Kanoh ,  Masato Kobori

    发明人： Susumu Igarashi ,  Ryo Naito ,  Yoshinori Okamoto ,  Noriyuki Kawano ,  Issei Tsukamoto ,  Ippei Sato ,  Makoto Takeuchi ,  Hiroyuki Kanoh ,  Masato Kobori

    IPC分类号： C07D487/04 ,  A61K31/5025 ,  A61P19/08

    CPC分类号： C07D487/04

    摘要： As a result of an effort made by us for the purpose of developing a therapeutic agent having a bone formation-stimulating effect by promoting the functions of osteoblasts, the present inventors discovered that a certain nitrogen-containing heterocyclic compound exhibits a potent bone formation-stimulating effect on the osteoblast and thus can serve as an excellent prophylactic or therapeutic agent against a metabolic bone disease, whereby establishing the present invention.Thus, the present invention provides a 3,6-disubstituted 1,2,4-triazolo[4,3-b]pyridazine compound or a pharmaceutically acceptable salt thereof as well as a pharmaceutical composition comprising such a compound and a pharmaceutically acceptable carrier, especially a bone-forming agent.

    摘要翻译： 本发明人为了通过促进成骨细胞的功能开发具有促进骨形成刺激作用的治疗剂而作出努力的结果，发现某些含氮杂环化合物表现出强有力的骨形成刺激 对成骨细胞的作用，因此可以作为抗代谢性骨病的优异的预防或治疗剂，由此建立本发明。 因此，本发明提供了3,6-二取代的1,2,4-三唑并[4,3-b]哒嗪化合物或其药学上可接受的盐，以及包含这种化合物和药学上可接受的载体的药物组合物， 特别是骨形成剂。

    Pluripotent Cells Distributed Ubiquitously In Animal Tissue, Which Proliferate Selectively In Lower-Serum Culture
    5.
    发明申请
    Pluripotent Cells Distributed Ubiquitously In Animal Tissue, Which Proliferate Selectively In Lower-Serum Culture 审中-公开
    多能细胞分布在动物组织中，其选择性地在低血清培养物中增殖

    公开(公告)号：US20070202592A1

    公开(公告)日：2007-08-30

    申请号：US11631818

    申请日：2005-07-08

    申请人： Yasuo Kitagawa ,  Shuhei Torii ,  Kazuhiro Sakurada ,  Masato Kobori ,  Yuzuru Kamei ,  Hirotake Yamaguchi ,  Kazuhiro Toriyama ,  Toru Takada

    发明人： Yasuo Kitagawa ,  Shuhei Torii ,  Kazuhiro Sakurada ,  Masato Kobori ,  Yuzuru Kamei ,  Hirotake Yamaguchi ,  Kazuhiro Toriyama ,  Toru Takada

    IPC分类号： C12N5/06 ,  C12N5/08

    CPC分类号： C12N5/0667

    摘要： It is intended to provide a pluripotent cell having the following properties: (1) being contained in a mixed-cell type population obtained by enzymatic treatment of the tissue collected from an animal; (2) being contained in a sedimented cell population obtained by centrifugating the mixed-cell type population of the property (1); (3) selectively proliferating by culturing in a medium containing 2% (v/v) or lower serum and 1 to 100 ng/ml of fibroblast growth factor-2; and (4) being differentiated into cells having the characteristics of adipocytes, osteoblasts, chondrocytes, tendon cells, myocardial cells, myoblasts, neurocytes or vascular endothelial cells by adjusting the culture condition; cells having differentiated from the above cell; and a method of conveniently obtaining the pluripotent cell in a large amount.

    摘要翻译： 旨在提供具有以下性质的多能细胞：（1）包含在通过酶处理从动物收集的组织获得的混合细胞型群体中; （2）包含在通过离心所述性质的混合细胞型群体（1）获得的沉降细胞群体中; （3）通过在含有2％（v / v）或更低血清和1至100ng / ml成纤维细胞生长因子-2的培养基中培养而选择性增殖; （4）通过调节培养条件将细胞分化为具有脂肪细胞，成骨细胞，软骨细胞，肌腱细胞，心肌细胞，成肌细胞，神经细胞或血管内皮细胞特征的细胞; 与上述细胞有区别的细胞; 以及大量方便地获得多能细胞的方法。

    Method of Producing Nerve Cell
    7.
    发明申请
    Method of Producing Nerve Cell 审中-公开
    产生神经细胞的方法

    公开(公告)号：US20080305544A1

    公开(公告)日：2008-12-11

    申请号：US11571580

    申请日：2005-07-06

    申请人： Hiroo Iwata ,  Yoshiki Sasai ,  Hironori Yamazoe ,  Masato Kobori ,  Mitsuo Satoh ,  Keiichi Yano

    发明人： Hiroo Iwata ,  Yoshiki Sasai ,  Hironori Yamazoe ,  Masato Kobori ,  Mitsuo Satoh ,  Keiichi Yano

    IPC分类号： C12N5/06

    CPC分类号： C12N5/0619 ,  C12N2500/38 ,  C12N2506/02

    摘要： An Object of the present invention is to provide a process for producing a nerve cell by inducing differentiation of an embryonic stem cell, a method for inducing differentiation of the embryonic stem cell into a nerve cell, a medium to be used in the production process or differentiation induction method, or a method for improving purity of the nerve cell obtained by inducing differentiation of the embryonic stem cell. The present invention provides a process for producing a nerve cell which is applicable to treatment of neurodegenerative disease or the like easily, selectively or inexpensively by inducing differentiation induction of an embryonic stem cell using vitamin B12 or a salt thereof and heparin, a substance having heparin-like activity or a salt.

    摘要翻译： 本发明的目的是提供一种通过诱导胚胎干细胞的分化来产生神经细胞的方法，用于诱导将胚胎干细胞分化成神经细胞的方法，用于生产过程的培养基或 分化诱导方法或通过诱导胚胎干细胞分化而获得的提高神经细胞的纯度的方法。 本发明提供了通过使用维生素B12或其盐诱导胚胎干细胞的分化诱导和肝素（含有肝素的物质），可以容易地，选择性地或廉价地治疗神经变性疾病等的神经细胞的制造方法 类活动或盐。