公开(公告)号：US12234509B2

公开(公告)日：2025-02-25

申请号：US17165592

申请日：2021-02-02

Applicant: Natera, Inc.

Inventor： Solomon Moshkevich ,  Bernhard Zimmermann ,  Tudor Pompiliu Constantin ,  Huseyin Eser Kirkizlar ,  Allison Ryan ,  Styrmir Sigurjonsson ,  Felipe Acosta Archila ,  Ryan Swenerton

IPC: C12Q1/68 ,  C12Q1/6851 ,  C12Q1/6869 ,  C12Q1/6876

Abstract: The present disclosure provides methods for determining the status of an allograft within a transplant recipient from genotypic data measured from a mixed sample of DNA comprising DNA from both the transplant recipient and from the donor. The mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias, for example using massively multiplexed targeted PCR.

公开(公告)号：US11525159B2

公开(公告)日：2022-12-13

申请号：US17165592

申请日：2021-02-02

Applicant: Natera, Inc.

Inventor： Solomon Moshkevich ,  Bernhard Zimmermann ,  Tudor Pompiliu Constantin ,  Huseyin Eser Kirkizlar ,  Allison Ryan ,  Styrmir Sigurjonsson ,  Felipe Acosta Archila ,  Ryan Swenerton

IPC: C12Q1/68 ,  C12Q1/6869 ,  C12Q1/6876 ,  C12Q1/6851

Abstract: The present disclosure provides methods for determining the status of an allograft within a transplant recipient from genotypic data measured from a mixed sample of DNA comprising DNA from both the transplant recipient and from the donor. The mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias, for example using massively multiplexed targeted PCR.