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公开(公告)号：US20240199632A1
公开(公告)日：2024-06-20
申请号：US18517497
申请日：2023-11-22
申请人： National Health Research Institutes , National Sun Yat-Sen University , National Museum of Marine Biology and Aquarium
发明人： Lun Kelvin Tsou , Guang-Hao Niu , Hsing-Pang Hsieh , Mingzi Zhang , Zhi-Hong Wen , Ping-Jyun Sung
IPC分类号： C07D493/04 , C07D307/935 , C07D413/04
CPC分类号： C07D493/04 , C07D307/935 , C07D413/04
摘要： Disclosed are compounds compound of Formula (I):
Each variable is defined herein. Also included are pharmaceutical compositions containing such a compound and a method of treating an inflammatory condition.-
2.发明公开公开(公告)号：US20230372405A1
公开(公告)日：2023-11-23
申请号：US18351018
申请日：2023-07-12
发明人： Zhi-Hong Wen , Ping-Jyun Sung , Han-Chun Hung , Chun-Hong Chen , Yu-Chia Chang
IPC分类号： A61K35/614 , A61K8/96
CPC分类号： A61K35/614 , A61K8/965 , A61K2236/331
摘要： The present invention relates to a coral composite extract, a composition including the same and a method of producing the same. The coral composite extract includes at least two briarane-type diterpenoid compounds from corals of Briareum violaceum, B. excavatum and B. stechei, thereby being applied as an effective ingredient of a skin external use composition, a cosmetic composition and a medicinal composition.
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公开(公告)号：US09623077B2
公开(公告)日：2017-04-18
申请号：US14723914
申请日：2015-05-28
发明人： Zhi-Hong Wen , Jyh-Yih Chen
CPC分类号： A61K38/1706
摘要： The present invention relates to a method for alleviating pain in a subject in need thereof, which comprises administering an effective amount of piscidin (PCD) peptide and a pharmaceutically acceptable carrier to the subject.
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公开(公告)号：US11738055B2
公开(公告)日：2023-08-29
申请号：US17354358
申请日：2021-06-22
发明人： Zhi-Hong Wen , Ping-Jyun Sung , Han-Chun Hung , Chun-Hong Chen , Yu-Chia Chang
IPC分类号： C07D307/77 , A61K35/614 , A61K8/96
CPC分类号： A61K35/614 , A61K8/965 , A61K2236/331
摘要： The present invention relates to a coral composite extract, a composition including the same and a method of producing the same. The coral composite extract includes at least two briarane-type diterpenoid compounds from corals of Briareum violaceum, B. excavatum and B. stechei, thereby being applied as an effective ingredient of a skin external use composition, a cosmetic composition and a medicinal composition.
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公开(公告)号：US11628191B2
公开(公告)日：2023-04-18
申请号：US17354305
申请日：2021-06-22
发明人： Zhi-Hong Wen , Ping-Jyun Sung , Han-Chun Hung , Chun-Hong Chen , Yu-Chia Chang
IPC分类号： A61K35/614 , A61K8/96
摘要： The present invention relates to a coral composite extract, a composition including the same and a method of producing the same. The coral composite extract includes at least two briarane-type diterpenoid compounds from corals of Briareum violaceum, B. excavatum and B. stechei, thereby being applied as an effective ingredient of a skin external use composition, a cosmetic composition and a medicinal composition.
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公开(公告)号：US10849874B2
公开(公告)日：2020-12-01
申请号：US14958940
申请日：2015-12-04
发明人： Zhi-Hong Wen , Ping-Jyun Sung , Han-Chun Hung
IPC分类号： A61K31/343 , A61P17/02 , A61K35/614 , A61K31/365
摘要： The present invention relates to a method for modulating angiogenesis in a subject in need thereof, which comprises administering an effective amount of composition comprising excavatolide B and a pharmaceutically acceptable carrier to the subject.
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公开(公告)号：US09999658B2
公开(公告)日：2018-06-19
申请号：US15073660
申请日：2016-03-18
发明人： Zhi-Hong Wen , Ming-Hong Tai , Shi-Ying Huang , Chun-Sung Sung , Wu-Fu Chen , Chun-Hong Chen , Chien-Wei Feng , Han-Chun Hung , Hui-Min David Wang , Nan-Fu Chen
IPC分类号： A61K38/46 , G01N33/50 , A61K31/7088 , A61K48/00 , C12N15/00
CPC分类号： A61K38/465 , A61K31/7088 , A61K48/00 , C12N15/00 , C12Y301/03016 , G01N33/5088 , G01N2333/916
摘要： The present invention relates to a method for treating pain in a subject in need thereof, comprising administering an effective amount of a nucleic acid to the subject, wherein the nucleic acid comprises a PTEN nucleotide sequence of SEQ ID NO: 1. The present invention also provides a method for screening pharmaceutical compositions having an anti-pain effect, wherein the pharmaceutical compositions can stimulate the upregulation of PTEN.
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公开(公告)号：US20170087222A1
公开(公告)日：2017-03-30
申请号：US15073660
申请日：2016-03-18
发明人： Zhi-Hong Wen , Ming-Hong Tai , Shi-Ying Huang , Chun-Sung Sung , Wu-Fu Chen , Chun-Hong Chen , Chien-Wei Feng , Han-Chun Hung , Hui-Min David Wang , Nan-Fu Chen
IPC分类号： A61K38/46 , G01N33/50 , A61K31/7088
CPC分类号： A61K38/465 , A61K31/7088 , A61K48/00 , C12N15/00 , C12Y301/03016 , G01N33/5088 , G01N2333/916
摘要： The present invention relates to a method for treating pain in a subject in need thereof, comprising administering an effective amount of a nucleic acid to the subject, wherein the nucleic acid comprises a PTEN nucleotide sequence of SEQ ID NO: 1. The present invention also provides a method for screening pharmaceutical compositions having an anti-pain effect, wherein the pharmaceutical compositions can stimulate the upregulation of PTEN.
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公开(公告)号：US11963985B2
公开(公告)日：2024-04-23
申请号：US18351018
申请日：2023-07-12
发明人： Zhi-Hong Wen , Ping-Jyun Sung , Han-Chun Hung , Chun-Hong Chen , Yu-Chia Chang
IPC分类号： A61K31/00 , A61K8/96 , A61K35/614
CPC分类号： A61K35/614 , A61K8/965 , A61K2236/331
摘要： The present invention relates to a coral composite extract, a composition including the same and a method of producing the same. The coral composite extract includes at least two briarane-type diterpenoid compounds from corals of Briareum violaceum, B. excavatum and B. stechei, thereby being applied as an effective ingredient of a skin external use composition, a cosmetic composition and a medicinal composition.
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10.发明申请公开(公告)号：US20210308194A1
公开(公告)日：2021-10-07
申请号：US17354358
申请日：2021-06-22
发明人： Zhi-Hong Wen , Ping-Jyun Sung , Han-Chun Hung , Chun-Hong Chen , Yu-Chia Chang
IPC分类号： A61K35/614 , A61K8/96
摘要： The present invention relates to a coral composite extract, a composition including the same and a method of producing the same. The coral composite extract includes at least two briarane-type diterpenoid compounds from corals of Briareum violaceum, B. excavatum and B. stechei, thereby being applied as an effective ingredient of a skin external use composition, a cosmetic composition and a medicinal composition.
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