公开(公告)号：US20190152960A1

公开(公告)日：2019-05-23

申请号：US16248755

申请日：2019-01-15

申请人： National Institute of Biological Sciences, Beijing

发明人： Zhiyuan Zhang ,  Xiaodong Wang ,  Shaoqiang Huang ,  Xian Jiang ,  Li Li ,  Zhaolan Zhang ,  Jianguang Han

IPC分类号： C07D409/04 ,  C07D409/14 ,  C07D239/38 ,  C07D401/10 ,  C07D401/04 ,  C07D239/47 ,  C07D403/04 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D495/04 ,  C07D471/04 ,  A61P25/16

摘要： The invention provides compounds that are inhibitors or covalent modifiers of succinate dehydrogenase subunit B (SDHB) and/or inhibitors of apoptosis, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition.

公开(公告)号：US11034680B2

公开(公告)日：2021-06-15

申请号：US16248755

申请日：2019-01-15

申请人： National Institute of Biological Sciences, Beijing

发明人： Zhiyuan Zhang ,  Xiaodong Wang ,  Shaoqiang Huang ,  Xian Jiang ,  Li Li ,  Zhaolan Zhang ,  Jianguang Han

IPC分类号： C07D409/04 ,  A61P25/16 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D401/04 ,  C07D401/10 ,  C07D403/04 ,  C07D239/38 ,  C07D239/47 ,  C07D409/14 ,  C07D417/14 ,  C07D495/04 ,  A61K31/506 ,  A61P37/00 ,  A61K31/505 ,  A61P25/00 ,  A61P9/10 ,  A61P25/28 ,  C07D471/04

摘要： The invention provides compounds that are inhibitors or covalent modifiers of succinate dehydrogenase subunit B (SDHB) and/or inhibitors of apoptosis, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition.

公开(公告)号：US11725000B2

公开(公告)日：2023-08-15

申请号：US17333033

申请日：2021-05-28

申请人： National Institute of Biological Sciences, Beijing

发明人： Zhiyuan Zhang ,  Xiaodong Wang ,  Shaoqiang Huang ,  Xian Jiang ,  Li Li ,  Zhaolan Zhang ,  Jianguang Han

IPC分类号： C07D409/04 ,  A61P25/16 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D401/04 ,  C07D401/10 ,  C07D403/04 ,  C07D239/38 ,  C07D239/47 ,  C07D409/14 ,  C07D417/14 ,  C07D495/04 ,  A61K31/506 ,  A61P37/00 ,  A61K31/505 ,  A61P25/00 ,  A61P9/10 ,  A61P25/28 ,  C07D471/04

CPC分类号： C07D409/04 ,  A61K31/505 ,  A61K31/506 ,  A61P9/10 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28 ,  A61P37/00 ,  C07D239/38 ,  C07D239/47 ,  C07D401/04 ,  C07D401/10 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04

摘要： The invention provides compounds that are inhibitors or covalent modifiers of succinate dehydrogenase subunit B (SDHB) and/or inhibitors of apoptosis, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition.

公开(公告)号：US20210309647A1

公开(公告)日：2021-10-07

申请号：US17333033

申请日：2021-05-28

申请人： National Institute of Biological Sciences, Beijing

发明人： Zhiyuan Zhang ,  Xiaodong Wang ,  Shaoqiang Huang ,  Xian Jiang ,  Li Li ,  Zhaolan Zhang ,  Jianguang Han

IPC分类号： C07D409/04 ,  C07D495/04 ,  A61K31/506 ,  A61P9/10 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28 ,  A61P37/00 ,  C07D239/38 ,  C07D239/47 ,  C07D401/04 ,  C07D401/10 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  A61K31/505

摘要： The invention provides compounds that are inhibitors or covalent modifiers of succinate dehydrogenase subunit B (SDHB) and/or inhibitors of apoptosis, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition.