-
公开(公告)号:US20190152960A1
公开(公告)日:2019-05-23
申请号:US16248755
申请日:2019-01-15
发明人: Zhiyuan Zhang , Xiaodong Wang , Shaoqiang Huang , Xian Jiang , Li Li , Zhaolan Zhang , Jianguang Han
IPC分类号: C07D409/04 , C07D409/14 , C07D239/38 , C07D401/10 , C07D401/04 , C07D239/47 , C07D403/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D495/04 , C07D471/04 , A61P25/16
摘要: The invention provides compounds that are inhibitors or covalent modifiers of succinate dehydrogenase subunit B (SDHB) and/or inhibitors of apoptosis, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition.
-
公开(公告)号:US20170290790A1
公开(公告)日:2017-10-12
申请号:US15632412
申请日:2017-06-26
发明人: Zhiyuan Zhang , Xiaodong Wang , Xiaoguang Lei , Yaning Su , Sudan He , Hanying Ruan , Liming Sun
IPC分类号: A61K31/165 , C07C25/13 , C07C233/05 , C07C25/02 , A61K31/10 , C07C233/01
CPC分类号: A61K31/165 , A61K31/10 , C07C25/02 , C07C25/13 , C07C233/01 , C07C233/05 , C07C233/13 , C07C233/18 , C07C233/47 , C07C233/59 , C07C235/10 , C07C237/06 , C07C237/22 , C07C255/60 , C07C259/06 , C07C275/24 , C07C311/14 , C07C313/06 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2603/74 , C07D211/28 , C07D213/40 , C07D213/61 , C07D213/64 , C07D217/14 , C07D231/12 , C07D277/28 , C07D307/14 , C07D307/52 , C07D333/20
摘要: The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.
-
公开(公告)号:US11478438B2
公开(公告)日:2022-10-25
申请号:US16787052
申请日:2020-02-11
发明人: Zhiyuan Zhang , Xiaodong Wang , Yaning Su , Hanying Ruan , Yan Ren
IPC分类号: A61K31/165 , A61K31/10 , A61K31/167 , C07C233/01 , C07C235/38 , C07D231/02 , C07D263/04 , C07D205/04 , C07D265/30 , C07D207/12 , C07D211/70 , C07D231/04 , C07D231/08 , C07D233/38 , C07D405/04 , C07D409/04 , C07D241/04 , C07D417/04 , C07D261/02 , C07D263/22 , C07D203/18 , C07D205/08 , C07D207/06 , C07D207/08 , C07D207/20 , C07D207/24 , C07D207/27 , C07D207/333 , C07D211/16 , C07D211/82 , G01C19/5649 , G01C19/5747
摘要: The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.
-
公开(公告)号:US10682319B2
公开(公告)日:2020-06-16
申请号:US15985698
申请日:2018-05-22
发明人: Zhiyuan Zhang , Xiaodong Wang , Xiaoguang Lei , Yaning Su , Sudan He , Hanying Ruan , Liming Sun
IPC分类号: C07C255/60 , C07C275/24 , C07C311/14 , C07C313/06 , C07D231/12 , C07D217/14 , C07D333/20 , C07D277/28 , C07D211/28 , C07D213/40 , C07D213/61 , C07D213/64 , C07D307/14 , C07D307/52 , C07C233/05 , C07C233/13 , C07C233/18 , C07C233/47 , C07C233/59 , C07C233/01 , C07C235/10 , C07C237/06 , C07C237/22 , C07C25/02 , C07C25/13 , C07C259/06 , A61K31/10 , A61K31/165
摘要: The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.
-
公开(公告)号:US10555920B2
公开(公告)日:2020-02-11
申请号:US16153706
申请日:2018-10-06
发明人: Zhiyuan Zhang , Xiaodong Wang , Yaning Su , Hanying Ruan , Yan Ren
IPC分类号: A61K31/10 , A61K31/165 , A61K31/167 , C07D263/04 , C07D265/30 , C07D207/12 , C07D211/70 , C07D231/04 , C07D231/08 , C07D233/38 , C07D405/04 , C07D409/04 , C07D241/04 , C07D417/04 , C07D261/02 , C07D263/22 , C07D203/18 , C07D205/08 , C07D207/06 , C07D207/08 , C07D207/20 , C07D207/24 , C07D207/27 , C07D207/333 , C07D211/16 , C07D211/82 , C07D231/02 , C07C233/01 , C07C235/38 , C07D205/04
摘要: The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.
-
公开(公告)号:US09974762B2
公开(公告)日:2018-05-22
申请号:US15632412
申请日:2017-06-26
发明人: Zhiyuan Zhang , Xiaodong Wang , Xiaoguang Lei , Yaning Su , Sudan He , Hanying Ruan , Liming Sun
IPC分类号: A61K31/165 , A61K31/10 , C07C25/13 , C07C25/02 , C07C233/05 , C07C233/01
CPC分类号: A61K31/165 , A61K31/10 , C07C25/02 , C07C25/13 , C07C233/01 , C07C233/05 , C07C233/13 , C07C233/18 , C07C233/47 , C07C233/59 , C07C235/10 , C07C237/06 , C07C237/22 , C07C255/60 , C07C259/06 , C07C275/24 , C07C311/14 , C07C313/06 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2603/74 , C07D211/28 , C07D213/40 , C07D213/61 , C07D213/64 , C07D217/14 , C07D231/12 , C07D277/28 , C07D307/14 , C07D307/52 , C07D333/20
摘要: The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.
-
公开(公告)号:US20170304237A1
公开(公告)日:2017-10-26
申请号:US15632422
申请日:2017-06-26
发明人: Zhiyuan Zhang , Xiaodong Wang , Yaning Su , Hanying Ruan , Yan Ren
IPC分类号: A61K31/165 , C07D231/02 , C07C235/38 , A61K31/10 , C07C233/01 , A61K31/167 , C07D241/04 , C07D205/08
CPC分类号: A61K31/165 , A61K31/10 , A61K31/167 , C07C233/01 , C07C235/38 , C07D203/18 , C07D205/04 , C07D205/08 , C07D207/06 , C07D207/08 , C07D207/12 , C07D207/20 , C07D207/24 , C07D207/27 , C07D207/333 , C07D211/16 , C07D211/70 , C07D211/82 , C07D231/02 , C07D231/04 , C07D231/08 , C07D233/38 , C07D241/04 , C07D261/02 , C07D263/04 , C07D263/22 , C07D265/30 , C07D405/04 , C07D409/04 , C07D417/04
摘要: The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.
-
公开(公告)号:US20200046714A1
公开(公告)日:2020-02-13
申请号:US16656574
申请日:2019-10-18
发明人: Xiaodong Wang , Dianrong Li , Lingjun Meng , Zhiyuan Zhang
IPC分类号: A61K31/522 , A61K31/165 , A61K31/4453 , A61K31/44 , A61K31/381 , A61K31/341 , A61K31/426 , A61K31/415 , A61K31/47 , A61K31/18 , A61K31/17 , A61K31/396 , A61K31/397 , A61K31/40 , A61K31/5375 , A61P15/08
摘要: The invention provides methods of treating male reproductive senescence comprising administering to a male in need thereof a necroptosis inhibitor, including inhibitors of RIP1, RIP3 or MLKL. The invention also provides pharmaceutical compositions comprising a necroptosis inhibitor and a second different drug for treating male senescence.
-
公开(公告)号:US10092529B2
公开(公告)日:2018-10-09
申请号:US15632422
申请日:2017-06-26
发明人: Zhiyuan Zhang , Xiaodong Wang , Yaning Su , Hanying Ruan , Yan Ren
IPC分类号: A61K31/165 , A61K31/10 , A61K31/167 , C07D241/04 , C07D205/08 , C07D231/02 , C07C233/01 , C07C235/38
摘要: The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.
-
公开(公告)号:US20180263934A1
公开(公告)日:2018-09-20
申请号:US15985698
申请日:2018-05-22
发明人: Zhiyuan Zhang , Xiaodong Wang , Xiaoguang Lei , Yaning Su , Sudan He , Hanying Ruan , Liming Sun
IPC分类号: A61K31/165 , C07C25/02 , C07C233/01 , C07C25/13 , C07C233/05 , A61K31/10
摘要: The invention provides amides that inhibit cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), including corresponding sulfonamides, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.
-
-
-
-
-
-
-
-
-