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    SALTS OF POTASSIUM ATP CHANNEL OPENERS AND USES THEREOF
    2.
    发明申请
    SALTS OF POTASSIUM ATP CHANNEL OPENERS AND USES THEREOF 审中-公开
    钾ATP通道开口的盐及其用途

    公开(公告)号：US20100256360A1

    公开(公告)日：2010-10-07

    申请号：US12819155

    申请日：2010-06-18

    申请人： Neil M. Cowen ,  Khaled A. Yamout

    发明人： Neil M. Cowen ,  Khaled A. Yamout

    IPC分类号： C07D285/24

    CPC分类号： A61K31/549 ,  A61K9/2086 ,  A61K31/54 ,  A61K38/27 ,  A61K45/06 ,  C07C209/68 ,  C07C213/08 ,  C07D285/24

    摘要： Provided are immediate or prolonged administration of certain salts of KATP channel openers such as diazoxide to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving KATP channels. Also provided are pharmaceutical formulations, methods of administration and dosing of the salts that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are method of co-administering the salts with other drugs to treat diseases of humans and animals.

    摘要翻译： 提供对受试者立即或长期给予KATP通道开放剂如二氮嗪的某些盐，以在治疗涉及KATP通道的疾病或病症中获得新颖的药效学，药代动力学，治疗学，生理学，代谢和组合结果。 还提供了实现这些结果的药物制剂，施用方法和给药盐，并减少治疗个体的不良反应的发生率。 进一步提供了与其它药物共同施用盐以治疗人和动物疾病的方法。

    Salts of potassium ATP channel openers and uses thereof
    4.
    发明授权
    Salts of potassium ATP channel openers and uses thereof 有权
    钾ATP通道开放剂的盐及其用途

    公开(公告)号：US07799777B2

    公开(公告)日：2010-09-21

    申请号：US11614044

    申请日：2006-12-20

    申请人： Neil M. Cowen ,  Khaled A. Yamout

    发明人： Neil M. Cowen ,  Khaled A. Yamout

    IPC分类号： A61K31/549 ,  C07D285/22

    CPC分类号： A61K31/549 ,  A61K9/2086 ,  A61K31/54 ,  A61K38/27 ,  A61K45/06 ,  C07C209/68 ,  C07C213/08 ,  C07D285/24

    摘要： Provided are immediate or prolonged administration of certain salts of KATP channel openers such as diazoxide to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving KATP channels. Also provided are pharmaceutical formulations, methods of administration and dosing of the salts that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are method of co-administering the salts with other drugs to treat diseases of humans and animals.

    摘要翻译： 提供对受试者立即或长期给予KATP通道开放剂如二氮嗪的某些盐，以在治疗涉及KATP通道的疾病或病症中获得新颖的药效学，药代动力学，治疗学，生理学，代谢和组合结果。 还提供了实现这些结果的药物制剂，施用方法和给药盐，并减少治疗个体的不良反应的发生率。 进一步提供了与其它药物共同施用盐以治疗人和动物疾病的方法。

    Salts of potassium ATP channel openers and uses thereof
    5.
    发明授权
    Salts of potassium ATP channel openers and uses thereof 有权
    钾ATP通道开放剂的盐及其用途

    公开(公告)号：US07572789B2

    公开(公告)日：2009-08-11

    申请号：US12391990

    申请日：2009-02-24

    申请人： Neil M. Cowen ,  Kenneth B. Kashkin ,  Khaled A. Yamout

    发明人： Neil M. Cowen ,  Kenneth B. Kashkin ,  Khaled A. Yamout

    IPC分类号： A61K31/549 ,  C07D285/22

    CPC分类号： A61K31/549 ,  A61K9/2086 ,  A61K31/54 ,  A61K38/27 ,  A61K45/06 ,  C07C209/68 ,  C07C213/08 ,  C07D285/24

    摘要： Provided are immediate or prolonged administration of certain salts of KATP channel openers such as diazoxide to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving KATP channels. Also provided are pharmaceutical formulations, methods of administration and dosing of the salts that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are method of co-administering the salts with other drugs to treat diseases of humans and animals.

    摘要翻译： 提供对受试者立即或长期给予KATP通道开放剂如二氮嗪的某些盐，以在治疗涉及KATP通道的疾病或病症中获得新颖的药效学，药代动力学，治疗学，生理学，代谢和组合结果。 还提供了实现这些结果的药物制剂，施用方法和给药盐，并减少治疗个体的不良反应的发生率。 进一步提供了与其它药物共同施用盐以治疗人和动物疾病的方法。

    SALTS OF POTASSIUM ATP CHANNEL OPENERS AND USES THEREOF
    8.
    发明申请
    SALTS OF POTASSIUM ATP CHANNEL OPENERS AND USES THEREOF 审中-公开
    钾ATP通道开口的盐及其用途

    公开(公告)号：US20090062264A1

    公开(公告)日：2009-03-05

    申请号：US12166251

    申请日：2008-07-01

    申请人： Neil M. Cowen ,  Iain Dukes

    发明人： Neil M. Cowen ,  Iain Dukes

    IPC分类号： A61K31/549

    CPC分类号： A61K31/54

    摘要： Provided are immediate or prolonged administration of certain salts of KATP channel openers such as diazoxide to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving KATP channels. Also provided are pharmaceutical formulations, methods of administration and dosing of the salts that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are method of co-administering the salts with other drugs to treat diseases of humans and animals.

    摘要翻译： 提供对受试者立即或长期给予KATP通道开放剂如二氮嗪的某些盐，以在治疗涉及KATP通道的疾病或病症中获得新颖的药效学，药代动力学，治疗学，生理学，代谢和组合结果。 还提供了实现这些结果的药物制剂，施用方法和给药盐，并减少治疗个体的不良反应的发生率。 进一步提供了与其它药物共同施用盐以治疗人和动物疾病的方法。

    SALTS OF POTASSIUM ATP CHANNEL OPENERS AND USES THEREOF
    9.
    发明申请
    SALTS OF POTASSIUM ATP CHANNEL OPENERS AND USES THEREOF 审中-公开

    公开(公告)号：US20130040942A1

    公开(公告)日：2013-02-14

    申请号：US13543665

    申请日：2012-07-06

    申请人： Neil M. Cowen ,  Iain Dukes

    发明人： Neil M. Cowen ,  Iain Dukes

    IPC分类号： A61K31/549 ,  A61P5/00 ,  A61P3/08 ,  A61P3/06

    CPC分类号： A61K31/54

    摘要： Provided are immediate or prolonged administration of certain salts of KATP channel openers such as diazoxide to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving KATP channels. Also provided are pharmaceutical formulations, methods of administration and dosing of the salts that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are method of co-administering the salts with other drugs to treat diseases of humans and animals.

    SALTS OF POTASSIUM ATP CHANNEL OPENERS AND USES THEREOF
    10.
    发明申请
    SALTS OF POTASSIUM ATP CHANNEL OPENERS AND USES THEREOF 审中-公开
    钾ATP通道开口的盐及其用途

    公开(公告)号：US20120238554A1

    公开(公告)日：2012-09-20

    申请号：US13406482

    申请日：2012-02-27

    申请人： Neil M. Cowen

    发明人： Neil M. Cowen

    IPC分类号： A61K31/549 ,  A61P1/16 ,  C07D285/24 ,  A61P3/06

    CPC分类号： A61K31/549

    摘要： Provided are immediate or prolonged administration of certain salts of KATP channel openers such as diazoxide to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving KATP channels. Also provided are pharmaceutical formulations, methods of administration and dosing of the salts that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are method of co-administering the salts with other drugs to treat diseases of humans and animals.

    摘要翻译： 提供对受试者立即或长期给予KATP通道开放剂如二氮嗪的某些盐，以在治疗涉及KATP通道的疾病或病症中获得新颖的药效学，药代动力学，治疗学，生理学，代谢和组合结果。 还提供了实现这些结果的药物制剂，施用方法和给药盐，并减少治疗个体的不良反应的发生率。 进一步提供了与其它药物共同施用盐以治疗人和动物疾病的方法。