公开(公告)号：US4718268A

公开(公告)日：1988-01-12

申请号：US741052

申请日：1985-06-04

申请人： Neil M. Reid ,  William R. Davidson

发明人： Neil M. Reid ,  William R. Davidson

IPC分类号： G01N1/02 ,  G01N1/28 ,  G01V9/00 ,  G01N1/22 ,  G01N33/22

CPC分类号： G01V9/007 ,  G01N2001/022 ,  G01N2001/2833

摘要： A method of detecting contraband substances in freight cargo containers in which the container is agitated to disturb particulates therein, and air containing such particulates is then sampled and the particulates collected. The collected particulates include naturally occurring particulates which have absorbed vapors of the contraband substance during the entire time that the container has been closed, and also include particulates of the contraband substance itself. The collected particulates are then heated to a temperature above 160.degree. C. to drive off vapors indicative of the contraband substance and the vapors are analyzed in a mass analyzer.

摘要翻译： 检测货物容器中违禁物质的方法，其中搅拌容器以扰乱其中的颗粒，然后对含有这种颗粒的空气进行取样并收集颗粒物。 收集的颗粒物包括在容器已经关闭的整个时间内吸收了违禁物质的蒸汽的天然存在的颗粒，并且还包括违禁物质本身的颗粒。 然后将收集的颗粒加热至高于160℃的温度以驱除指示违禁物质的蒸汽，并在质量分析器中分析蒸汽。

公开(公告)号：US4580440A

公开(公告)日：1986-04-08

申请号：US631953

申请日：1984-07-17

申请人： Neil M. Reid ,  William R. Davidson

发明人： Neil M. Reid ,  William R. Davidson

IPC分类号： G01N1/02 ,  G01N1/28 ,  G01V9/00 ,  G01N1/22 ,  G01N33/22

CPC分类号： G01V9/007 ,  G01N2001/022 ,  G01N2001/025 ,  G01N2001/2833

摘要： A method of detecting contraband substances in freight cargo containers in which the container is agitated to disturb particulates therein, and air containing such particulates is then sampled and the particulates collected. The collected particulates include naturally occurring particulates which have absorbed vapors of the contraband substance during the entire time that the container has been closed, and also include particulates of the contraband substance itself. The collected particulates are heated to drive off vapors indicative of the contraband substance and the vapors are analyzed in a mass analyzer.

摘要翻译： 检测货物容器中违禁物质的方法，其中搅拌容器以扰乱其中的颗粒，然后对含有这种颗粒的空气进行取样并收集颗粒物。 收集的颗粒包括在容器已经关闭的整个时间内已经吸收了违禁物质的蒸气的天然存在的颗粒，并且还包括违禁物质本身的颗粒。 收集的颗粒被加热以驱除指示违禁物质的蒸汽，并且在质量分析器中分析蒸气。

公开(公告)号：US07317187B2

公开(公告)日：2008-01-08

申请号：US11135490

申请日：2005-05-24

申请人： William R. Davidson ,  Bori Shushan ,  Peter Kovarik ,  Tom R. Covey ,  John D. Brennan

发明人： William R. Davidson ,  Bori Shushan ,  Peter Kovarik ,  Tom R. Covey ,  John D. Brennan

IPC分类号： B01D59/44

CPC分类号： H01J49/164 ,  H01J49/0413

摘要： Sol-gel derived monolithic silica columns containing entrapped dihydrofolate reductase were used for frontal affinity chromatography of small molecule mixtures. The output from the column combined with a second stream containing the matrix molecule (HCCA) and was directly deposited onto a conventional MALDI plate that moved relative to the column via a computer controlled x-y stage, creating a semi-permanent record of the FAC run. The use of MALDI MS allowed for a decoupling of the FAC and MS methods allowing significantly higher ionic strength buffers to be used for FAC studies, which allowed for better retention of protein activity over multiple runs.

摘要翻译： 使用含有截留二氢叶酸还原酶的溶胶 - 凝胶衍生的整体硅胶柱用于小分子混合物的正面亲和层析。 来自柱的输出与含有基质分子（HCCA）的第二流组合，并直接沉积到通过计算机控制的x-y阶段相对于柱移动的常规MALDI板上，形成FAC运行的半永久记录。 使用MALDI MS允许FAC和MS方法的去耦，从而允许显着更高的离子强度缓冲液用于FAC研究，这允许在多次运行中更好地保​​留蛋白质活性。