公开(公告)号：US20240299561A1

公开(公告)日：2024-09-12

申请号：US18570610

申请日：2022-06-17

申请人： Nektar Therapeutics

发明人： Antoni Kozlowski ,  Neel K. Anand ,  Xiaoming Shen ,  Xiaobing Wang

IPC分类号： A61K47/60 ,  C08G65/333

CPC分类号： A61K47/60 ,  C08G65/3332

摘要： The instant disclosure provides (among other things) novel water-soluble polymer reagents capable of selective conjugation to histidine residues. e.g., in peptides and proteins, as well the resulting conjugates and related compositions. In addition, provided are methods of preparing the polymer reagents, as well as methods for conjugating the polymer reagents to active agents and other substances, pharmaceutical compositions, and methods for administering the conjugates.