公开(公告)号：US11858943B2

公开(公告)日：2024-01-02

申请号：US17500780

申请日：2021-10-13

申请人： Neumora Therapeutics, Inc.

发明人： Robert M. Jones ,  Mariangela Urbano ,  Gary Brandt ,  David Hardick ,  Chris Knight ,  Jason Tierney

IPC分类号： C07D487/04 ,  A61P15/08 ,  A61P15/10 ,  A61P25/20 ,  C07D498/04 ,  A61P9/06 ,  A61P25/18 ,  A61P25/22 ,  C07D491/04 ,  A61P25/24

CPC分类号： C07D487/04 ,  A61P9/06 ,  A61P15/08 ,  A61P15/10 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  C07D491/04 ,  C07D498/04

摘要： Compounds are provided that antagonize vasopressin receptors, particularly the V1a receptor products containing such compounds, as well as to methods of their use and synthesis. Such compounds have the structure of Formula (I), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof:




wherein A, B, G, R1, R1b, R1c, R2 and X are as defined herein.