公开(公告)号：US20190183905A1

公开(公告)日：2019-06-20

申请号：US16217752

申请日：2018-12-12

申请人： Texas Tech University System

发明人： John J. McGlone

IPC分类号： A61K31/5685 ,  A61K31/568 ,  A61K31/47 ,  A61K47/10 ,  A61K47/44 ,  A61K9/00 ,  A61K9/12 ,  A61P15/08

CPC分类号： A61K31/5685 ,  A61K9/0043 ,  A61K9/122 ,  A61K31/47 ,  A61K31/568 ,  A61K47/10 ,  A61K47/44 ,  A61P15/08

摘要： The present disclosure provides for pheromonal compositions and methods of using the compositions for stimulating early onset of estrus in a peri-pubertal suid and methods of improving performance of the peri-pubertal female suid. The composition may comprise at least one steroid hormone and a heterocyclic aromatic compound. The method comprises administering the pheromone composition to the suid for a period of time.

公开(公告)号：US20180264086A1

公开(公告)日：2018-09-20

申请号：US15760846

申请日：2016-09-16

申请人： Glycotope GmbH

发明人： Steffen Goletz ,  Lars Stoeckl

IPC分类号： A61K38/24 ,  A61K47/10 ,  A61K47/18 ,  A61K9/00 ,  A61P15/08

CPC分类号： A61K38/24 ,  A61K9/0019 ,  A61K47/10 ,  A61K47/183 ,  A61P15/08

摘要： The present invention pertains to the field of gonadotropins. In particular, an improved composition comprising recombinant human follicle-stimulating hormone and chlorocresol is provided. This improved composition has an increased stability at high temperatures and is useful in the treatment of infertility, in particular in human patients.

公开(公告)号：US10076511B2

公开(公告)日：2018-09-18

申请号：US15576387

申请日：2016-05-26

申请人： TREAMID GmbH

发明人： Vladimir Evgenievich Nebolsin ,  Anastasia Vladimirovna Rydlovskaya ,  Alexandr Mikhailovich Dygai ,  Tatiana Gennadievna Borovskaya ,  Evgenii Germanovich Skurikhin

IPC分类号： A61K31/417 ,  A61P19/04 ,  A61P3/08 ,  A61P31/20 ,  A61P1/18 ,  A61P15/08 ,  A61P11/00

CPC分类号： A61K31/417 ,  A61K31/16 ,  A61K31/4164 ,  A61P1/18 ,  A61P3/08 ,  A61P11/00 ,  A61P15/08 ,  A61P19/04 ,  A61P31/20

摘要： The invention relates to the field of medicine and concerns an agent that stimulates tissue regeneration and the recovery of diminished tissue and organ function. A medicinal agent for the treatment and/or prophylaxis of a pathological condition selected from the group including metabolic syndrome, impaired glucose tolerance, hepatitis, particularly chronic hepatitis and toxic hepatitis, idiopathic pulmonary fibrosis (IPF), emphysema of the lungs, chronic obstructive pulmonary disease (COPD) and cachexia, particularly as a result of impaired glucose tolerance, pulmonary fibrosis, chronic obstructive pulmonary disease, cancer and other diseases, is proposed in the form of an agent based on Treamide. The latter is a bisamide derivative of dicarboxylic acid of formula (I) or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20180139997A1

公开(公告)日：2018-05-24

申请号：US15736637

申请日：2016-06-15

申请人： GEXNANO S.R.L.

发明人： Massimo MARIOTTI ,  Alesandro SCOZZESI ,  Renato COLOGNATO ,  Massimiliano MANGANINI ,  Giuseppe PIGOLI

IPC分类号： A23L33/105 ,  A23L33/18 ,  A61K36/67 ,  A61K36/9066 ,  A61K31/445 ,  A61K38/48 ,  A61K9/48 ,  A61P15/08

CPC分类号： A23L33/105 ,  A23L33/10 ,  A23L33/18 ,  A23V2002/00 ,  A23V2200/30 ,  A23V2200/324 ,  A23V2250/1846 ,  A23V2250/1848 ,  A23V2250/185 ,  A23V2250/1852 ,  A23V2250/2112 ,  A23V2250/5436 ,  A61K9/4858 ,  A61K31/12 ,  A61K31/445 ,  A61K36/67 ,  A61K36/9066 ,  A61K38/4873 ,  A61P15/08 ,  A61K2300/00

摘要： A composition for a food supplement comprising a substance capable of exerting an anti-oedemigenous and/or anti-inflammatory action in soft organic tissues, a substance capable of exerting an antioxidant action and at least one substance facilitating penetration, through a cell membrane, of the substance capable of exerting an anti-oedemigenous and/or anti¬inflammatory action and/or of the substance capable of exerting an antioxidant action, for use in the treatment of female infertility.

公开(公告)号：US20170065556A1

公开(公告)日：2017-03-09

申请号：US15104683

申请日：2014-12-15

申请人： OBSEVA S.A.

发明人： Andre Chollet ,  Olivier Pohl

IPC分类号： A61K31/40 ,  A61K45/06 ,  A61K9/20

CPC分类号： A61K31/40 ,  A61K9/0056 ,  A61K9/0095 ,  A61K9/20 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/2054 ,  A61K31/401 ,  A61K45/06 ,  A61K47/40 ,  A61P15/08

摘要： The present invention relates to solid oral formulations comprising a compound of formula (3Z,5S)-5-(hydroxymethyl)-1-[(2′-methyl-1,1′-biphenyl-4-yl)carbonyl]pyrrolidin-3-one-O-methyloxime, and/or an active metabolite thereof, and the use of said formulations in the treatment and/or prevention of preterm labor, premature birth, dysmenorrhea and embryo implantation failure due to uterine contractions. The present invention is furthermore related to processes for their preparation.

摘要翻译： 本发明涉及包含式（3Z，5S）-5-（羟甲基）-1 - [（2'-甲基-1,1'-联苯-4-基）羰基]吡咯烷-3 - 酮-O-甲基肟和/或其活性代谢物，以及所述制剂在治疗和/或预防由于子宫收缩引起的早产，早产，痛经和胚胎植入失败中的用途。 本发明还涉及其制备方法。

公开(公告)号：US20150272622A1

公开(公告)日：2015-10-01

申请号：US14642437

申请日：2015-03-09

申请人： Previvo Genetics, LLC

发明人： Sandra Ann Carson ,  John E. Buster ,  Moses Cesario ,  Steven Paul Woodard

IPC分类号： A61B17/435 ,  A61B19/02 ,  A61K38/09 ,  A61B17/42

CPC分类号： A61B17/435 ,  A61B17/42 ,  A61B17/425 ,  A61B50/13 ,  A61B50/20 ,  A61B50/31 ,  A61B2017/4216 ,  A61B2050/185 ,  A61B2050/3008 ,  A61B2050/3011 ,  A61B2050/311 ,  A61B2217/005 ,  A61B2217/007 ,  A61K9/0034 ,  A61K31/215 ,  A61K31/57 ,  A61K31/573 ,  A61K31/575 ,  A61K31/58 ,  A61K38/08 ,  A61K38/09 ,  A61K38/24 ,  A61K45/06 ,  A61K47/26 ,  A61P15/08 ,  C12Q1/6883 ,  C12Q2600/156

摘要： A kit having instructions for use for performing uterine lavage in a female patient includes a uterine lavage catheter configured for insertion into a woman's uterus to remove viable blastocysts from the uterus, and one or more first containers having a sufficient dosage amount of a GnRH antagonist to cause desynchronization of the endometrium of the patient prior to, during and/or following recovery of viable blastocysts from the uterus.

公开(公告)号：US20190183910A1

公开(公告)日：2019-06-20

申请号：US16311969

申请日：2017-06-21

申请人： NEW YORK MEDICAL COLLEGE

发明人： KUTLUK OKTAY

IPC分类号： A61K31/661 ,  A61P15/08 ,  C12N5/076

CPC分类号： A61K31/661 ,  A61P15/08 ,  C12N5/061

摘要： Embodiments of the present invention generally relate to methods for improving male fertility, and in particular for using sphingosine 1 phosphate (S1P) for improving the quality and/or longevity of sperm.

公开(公告)号：US20190040051A1

公开(公告)日：2019-02-07

申请号：US16073355

申请日：2017-02-10

申请人： GlaxoSmithKline Intellectual Property Development Limited

发明人： Niall Andrew ANDERSON ,  Nicholas Paul BARTON ,  Sebastien Andre CAMPOS ,  Edward Paul CANNONS ,  Anthony William James COOPER ,  Kenneth David DOWN ,  Kevin James DOYLE ,  Julie Nicole HAMBLIN ,  Graham George Adam INGLIS ,  Armelle LE GALL ,  Vipulkumar Kantibhai PATEL ,  Simon PEACE ,  Andrew SHARPE ,  Gemma Victoria WHITE

IPC分类号： C07D413/14 ,  A61P11/06 ,  A61P25/28 ,  A61P37/08 ,  A61P15/08 ,  A61P25/24

CPC分类号： C07D413/14 ,  A61P11/06 ,  A61P15/08 ,  A61P25/24 ,  A61P25/28 ,  A61P37/08 ,  C07D213/76

摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

公开(公告)号：US20180264011A1

公开(公告)日：2018-09-20

申请号：US15542500

申请日：2016-01-15

申请人： DSM IP Assets B.V.

发明人： Shuen Ei CHEN ,  Thau Kiong CHUNG

IPC分类号： A61K31/593 ,  A23K20/174 ,  A23K20/179 ,  A23K50/75 ,  A23K50/42 ,  A23K50/48 ,  A61K31/375 ,  A61K31/355 ,  A61K31/015 ,  A61P3/06 ,  A61P3/08 ,  A61P39/00 ,  A61P9/00

CPC分类号： A23K20/174 ,  A23K20/179 ,  A23K20/30 ,  A23K50/10 ,  A23K50/42 ,  A23K50/48 ,  A23K50/75 ,  A61K9/0056 ,  A61K31/015 ,  A61K31/122 ,  A61K31/197 ,  A61K31/355 ,  A61K31/375 ,  A61K31/4188 ,  A61K31/455 ,  A61K31/519 ,  A61K31/525 ,  A61K31/593 ,  A61K31/675 ,  A61K33/04 ,  A61K33/26 ,  A61K33/32 ,  A61K33/34 ,  A61P3/06 ,  A61P3/08 ,  A61P9/00 ,  A61P15/00 ,  A61P15/08 ,  A61P39/00

摘要： This invention relates to the use of the combination of 25-hydroxyvitamin D3 (“25-OH D3”) and antioxidants/anti-inflammatories (ascorbic acid vitamin E and canthaxanthin) to make a premix or feed which can ameliorate various problems observed in companion animals which have been subject to overfeeding. Foods containing the 25-OH D3 and antioxidants/anti-inflammatories and premixes are also provided.

公开(公告)号：US20180207214A1

公开(公告)日：2018-07-26

申请号：US15924961

申请日：2018-03-19

申请人： Membrane Protective Technologies, Inc.

发明人： Lisa A. Herickhoff ,  James A. Herickhoff

IPC分类号： A61K36/185

CPC分类号： A61K36/185 ,  A01N1/021 ,  A01N1/0226 ,  A61K31/724 ,  A61K36/45 ,  A61K36/48 ,  A61K36/63 ,  A61K36/73 ,  A61K36/736 ,  A61K36/87 ,  A61P15/08

摘要： Extracts obtained from the genus Hippophae or other plant sources or compositions produced by chemical or molecular biological techniques each having in common certain moieties in amounts effective when combined with reproductive cells to reduce the loss of function.