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1.发明公开公开(公告)号：US20240327542A1
公开(公告)日：2024-10-03
申请号：US18585676
申请日：2024-02-23
申请人： New York University
发明人： Shohei KOIDE , Benjamin NEEL , Carmine FEDELE , Kai Wen TENG , Akiko KOIDE , Takamitsu HATTORI , Lorenzo MASO
CPC分类号： C07K16/44 , A61K47/6849 , C07K16/2833 , C07K2317/56 , C07K2317/626
摘要： Provided are compositions and methods that include binding partners that bind with specificity to target sites on proteins or peptides that comprise a covalently attached molecule. The binding partners are provided as antibodies and antibody derivatives that specifically bind to proteins and peptides that have been covalently modified by attachment of a molecule, such as a drug. The binding partners can bind with specificity to covalently modified peptides when presented in the context of a major histocompatibility complex (MHC). Uses of the compositions and methods for prophylaxis or therapy of disorders are also provided.
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2.发明公开公开(公告)号：US20240228668A1
公开(公告)日：2024-07-11
申请号：US18547623
申请日：2022-02-28
申请人： New York University
发明人： Shohei KOIDE , Benjamin NEEL , Carmine FEDELE , Kai Wen TENG , Akiko KOIDE , Takamitsu HATTORI , Lorenzo MASO
CPC分类号： C07K16/44 , A61K47/6849 , C07K16/2833 , C07K2317/56 , C07K2317/626
摘要： Provided are compositions and methods that include binding partners that bind with specificity to target sites on proteins or peptides that comprise a covalently attached molecule. The binding partners are provided as antibodies and antibody derivatives that specifically bind to proteins and peptides that have been covalently modified by attachment of a molecule, such as a drug. The binding partners can bind with specificity to covalently modified peptides when presented in the context of a major histocompatibility complex (MHC). Uses of the compositions and methods for prophylaxis or therapy of disorders are also provided.
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