公开(公告)号：US20240327542A1

公开(公告)日：2024-10-03

申请号：US18585676

申请日：2024-02-23

申请人： New York University

发明人： Shohei KOIDE ,  Benjamin NEEL ,  Carmine FEDELE ,  Kai Wen TENG ,  Akiko KOIDE ,  Takamitsu HATTORI ,  Lorenzo MASO

IPC分类号： C07K16/44 ,  A61K47/68 ,  C07K16/28

CPC分类号： C07K16/44 ,  A61K47/6849 ,  C07K16/2833 ,  C07K2317/56 ,  C07K2317/626

摘要： Provided are compositions and methods that include binding partners that bind with specificity to target sites on proteins or peptides that comprise a covalently attached molecule. The binding partners are provided as antibodies and antibody derivatives that specifically bind to proteins and peptides that have been covalently modified by attachment of a molecule, such as a drug. The binding partners can bind with specificity to covalently modified peptides when presented in the context of a major histocompatibility complex (MHC). Uses of the compositions and methods for prophylaxis or therapy of disorders are also provided.

公开(公告)号：US20240025969A1

公开(公告)日：2024-01-25

申请号：US18252285

申请日：2021-11-10

申请人： NEW YORK UNIVERSITY

发明人： Craig RAMIREZ ,  Andrew HAUSER ,  Dafna BAR-SAGI ,  Akiko KOIDE ,  Shohei KOIDE

IPC分类号： C07K14/78 ,  C07K16/18 ,  A61K47/64

CPC分类号： C07K14/78 ,  C07K16/18 ,  A61K47/6435 ,  C07K2317/77 ,  C07K2318/20 ,  C07K2317/92 ,  C07K2317/73

摘要： The present invention is directed to Niemann-Pick disease, type C1 (NPC1) binding polypeptides and NPC1 binding peptide conjugates comprising these binding polypeptides. The present invention is further directed to pharmaceutical compositions comprising these NPC1 binding polypeptide and binding peptide conjugates and the use of these compositions to treat a variety of conditions, including cancer, infectious diseases, neurodegenerative diseases, inflammatory conditions, and bone conditions. The NPC1 binding conjugates are also useful for enhancing endosomal release of pharmaceutically active moieties.

公开(公告)号：US20220259304A1

公开(公告)日：2022-08-18

申请号：US17565994

申请日：2021-12-30

申请人： NEW YORK UNIVERSITY ,  argenx IIP BV

发明人： Steven J. BURDEN ,  Shohei KOIDE ,  Akiko KOIDE ,  Nadia LELOUP ,  Julien OURY ,  Karen SILENCE ,  Roeland VANHAUWAERT ,  Christophe BLANCHETOT

IPC分类号： C07K16/28 ,  A61P21/04

摘要： The present invention relates to antibody-based molecules, including full-length antibodies, antigen-binding domains thereof, and antibody derivatives that are capable of binding to and activating human muscle-specific tyrosine protein kinase (MuSK). The present invention further discloses methods of treating neuromuscular conditions using the aforementioned MuSK antibodies.

公开(公告)号：US20220204629A1

公开(公告)日：2022-06-30

申请号：US17598215

申请日：2020-03-25

申请人： New York University ,  PureTech LYT, Inc.

发明人： Shohei KOIDE ,  George MILLER ,  Akiko KOIDE ,  Linxiao CHEN ,  Aleksandra FILIPOVIC ,  Eric ELENKO ,  Joseph BOLEN

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61K31/7068 ,  A61K31/337 ,  A61P35/00

摘要： Disclosed herein are anti-Galectin-9 antibodies and methods of using in modulating (e.g., increasing) immune responses in a subject, either taken alone or in combination with an immune checkpoint inhibitor, such as a PD-1 inhibitor.

公开(公告)号：US20220073612A1

公开(公告)日：2022-03-10

申请号：US17424474

申请日：2020-01-23

申请人： New York University ,  PureTech LYT, Inc.

发明人： Shohei KOIDE ,  George MILLER ,  Akiko KOIDE ,  Tatyana PANCHENKO ,  Takamitsu HATTORI ,  Aleksandra FILIPOVIC ,  Eric ELENKO ,  Joseph BOLEN

IPC分类号： C07K16/28 ,  A61P35/00

摘要： Disclosed herein are antibodies specific to a delta-1 chain of a γδ T cell receptor and methods of using such for modulating γδ T cell bioactivity. Such anti-Delta 1 antibodies may also be used to treat diseases associated with γδ T cell activation, such as solid tumors, or for detecting presence of γδ1 T cells.

公开(公告)号：US20240327460A1

公开(公告)日：2024-10-03

申请号：US18294021

申请日：2022-08-05

申请人： NEW YORK UNIVERSITY

发明人： Shohei KOIDE ,  Da-Neng WANG ,  Nathaniel TRAASETH ,  Akiko KOIDE ,  Douglas BRAWLEY, Jr. ,  David SAUER

IPC分类号： C07K7/08 ,  A61K45/06 ,  A61P31/04 ,  C07K16/12 ,  G01N33/569

CPC分类号： C07K7/08 ,  A61K45/06 ,  A61P31/04 ,  C07K16/1271 ,  G01N33/56938 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/569 ,  C07K2317/92 ,  C07K2318/00 ,  G01N2333/31 ,  G01N2800/26

摘要： Disclosed herein are NorA peptide inhibitors, protein scaffolds including the NorA peptide inhibitor, and antibody-based molecules that bind NorA, as well as compositions containing the same. Also disclosed are combinations therapeutic agents that include an antibiotic and/or biocide; and a NorA inhibitor, protein scaffold, or antibody-based as disclosed herein. Use of these agents for treating a Staphylococcus aureus infection, potentiating the therapeutic efficacy of an antibiotic or biocide, diagnosing a S. aureus infection, and detecting NorA in a non-clinical biological sample are also disclosed.

公开(公告)号：US20240228668A1

公开(公告)日：2024-07-11

申请号：US18547623

申请日：2022-02-28

申请人： New York University

发明人： Shohei KOIDE ,  Benjamin NEEL ,  Carmine FEDELE ,  Kai Wen TENG ,  Akiko KOIDE ,  Takamitsu HATTORI ,  Lorenzo MASO

IPC分类号： C07K16/44 ,  A61K47/68 ,  C07K16/28

CPC分类号： C07K16/44 ,  A61K47/6849 ,  C07K16/2833 ,  C07K2317/56 ,  C07K2317/626

摘要： Provided are compositions and methods that include binding partners that bind with specificity to target sites on proteins or peptides that comprise a covalently attached molecule. The binding partners are provided as antibodies and antibody derivatives that specifically bind to proteins and peptides that have been covalently modified by attachment of a molecule, such as a drug. The binding partners can bind with specificity to covalently modified peptides when presented in the context of a major histocompatibility complex (MHC). Uses of the compositions and methods for prophylaxis or therapy of disorders are also provided.

公开(公告)号：US20230151091A1

公开(公告)日：2023-05-18

申请号：US17937630

申请日：2022-10-03

申请人： argenx IIP BV ,  New York University

发明人： Steven J. BURDEN ,  Shohei KOIDE ,  Akiko KOIDE ,  Nadia LELOUP ,  Julien OURY ,  Karen SILENCE ,  Roeland VANHAUWAERT ,  Christophe BLANCHETOT

IPC分类号： C07K16/28 ,  A61P21/04

CPC分类号： C07K16/28 ,  A61P21/04 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/622

摘要： The present invention relates to antibody-based molecules, including full-length antibodies, antigen-binding domains thereof, and antibody derivatives that are capable of binding to and activating human muscle-specific tyrosine protein kinase (MuSK). The present invention further discloses methods of treating neuromuscular conditions using the aforementioned MuSK antibodies.

公开(公告)号：US20240016944A1

公开(公告)日：2024-01-18

申请号：US18251712

申请日：2021-11-10

申请人： NEW YORK UNIVERSITY

发明人： Craig RAMIREZ ,  Andrew HAUSER ,  Nathan BEALS ,  Dafna BAR-SAGI ,  Akiko KOIDE ,  Shohei KOIDE

IPC分类号： A61K47/64 ,  A61K47/65 ,  A61K49/00 ,  A61K51/08 ,  A61K41/00

CPC分类号： A61K47/6435 ,  A61K47/65 ,  A61K49/0056 ,  A61K49/0002 ,  A61K51/088 ,  A61K51/08 ,  A61K41/0057

摘要： The present disclosure is directed to pharmaceutical and diagnostic compositions comprising macropinocytosis selective non-binding protein-drug conjugates. These non-binding protein-drug conjugates comprise a non-binding fibronectin type III (FN3) domain coupled to a pharmaceutically active moiety or a diagnostic moiety. The disclosure is also directed to methods of treatment and diagnosis that involve administering the pharmaceutical compositions described herein to a subject in need.

公开(公告)号：US20220185896A1

公开(公告)日：2022-06-16

申请号：US17607878

申请日：2020-05-01

申请人： New York University ,  PureTech LYT, Inc.

发明人： Shohei KOIDE ,  George MILLER ,  Akiko KOIDE ,  Linxiao CHEN ,  Aleksandra FILIPOVIC ,  Eric ELENKO ,  Joseph BOLEN

IPC分类号： C07K16/28 ,  A61P35/04 ,  A61P35/00

摘要： Disclosed herein are methods for treating solid tumors (e.g., pancreatic adenocarcinoma (PDA), colorectal cancer (CRC), hepatocellular carcinoma (HCC)), or Cholangiocarcinoma and others), including, but not limited to, metastatic tumors, using an anti-Galectin-9 antibody.