公开(公告)号：US08747385B2

公开(公告)日：2014-06-10

申请号：US13468956

申请日：2012-05-10

Applicant: Eugene T. Michal ,  Evgenia Mandrusov ,  Charles D. Claude ,  Ni Ding ,  Murthy Simhambhatla ,  Syed Faiyez Ahmed Hossainy ,  Srinivasan Sridharan ,  Paul Consigny

Inventor： Eugene T. Michal ,  Evgenia Mandrusov ,  Charles D. Claude ,  Ni Ding ,  Murthy Simhambhatla ,  Syed Faiyez Ahmed Hossainy ,  Srinivasan Sridharan ,  Paul Consigny

IPC: A61M31/00

CPC classification number: A61K9/0019 ,  A61K9/0024 ,  A61K31/7088

Abstract: Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.

公开(公告)号：US08394446B2

公开(公告)日：2013-03-12

申请号：US12485756

申请日：2009-06-16

Applicant: Ni Ding

Inventor： Ni Ding

IPC: B05D3/00

CPC classification number: A61F2/82 ,  A61L31/10 ,  A61L31/143 ,  B65B55/00 ,  B65D1/00 ,  B65D3/00 ,  B65D77/04 ,  C08K5/13

Abstract: Methods of incorporating an antioxidant into a medical device including a polymer are described, and methods of packaging medical devices.

Abstract translation: 本发明描述了将抗氧化剂并入包括聚合物的医疗装置中的方法，以及包装医疗装置的方法。

公开(公告)号：US07785647B2

公开(公告)日：2010-08-31

申请号：US11189216

申请日：2005-07-25

Applicant: Ni Ding

Inventor： Ni Ding

IPC: A61L33/00

CPC classification number: A61L31/10 ,  Y10T428/1307

Abstract: A method of providing an antioxidant to a medical device is described.

Abstract translation: 描述了向医疗装置提供抗氧化剂的方法。

公开(公告)号：US20090240325A1

公开(公告)日：2009-09-24

申请号：US12052452

申请日：2008-03-20

Applicant: Shaw Ling Hsu ,  Yiwen Tang ,  Lothar W. Kleiner ,  Fuh-Wei Tang ,  Ni Ding ,  Syed Faiyaz Ahmed Hossainy

Inventor： Shaw Ling Hsu ,  Yiwen Tang ,  Lothar W. Kleiner ,  Fuh-Wei Tang ,  Ni Ding ,  Syed Faiyaz Ahmed Hossainy

IPC: A61F2/06 ,  A61F2/02

CPC classification number: A61L27/34 ,  A61L31/10 ,  A61L2420/08 ,  C08L67/04

Abstract: Implantable medical device coatings that have improved mechanical stability and medical devices coated with such coatings are disclosed.

Abstract translation: 公开了具有改善的机械稳定性的植入式医疗装置涂层和涂覆有这种涂层的医疗装置。

公开(公告)号：US20090069883A1

公开(公告)日：2009-03-12

申请号：US12271265

申请日：2008-11-14

Applicant: Ni Ding ,  W. Scott Andrus

Inventor： Ni Ding ,  W. Scott Andrus

IPC: A61F2/82 ,  A61M25/10

CPC classification number: A61F2/86 ,  A61F2250/0068 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/236 ,  A61L2300/42 ,  A61L2300/606 ,  A61M25/104 ,  A61M2025/105 ,  A61M2025/1075 ,  A61M2025/1081

Abstract: The medical devices of the invention comprise an expandable portion which is covered with a sponge coating for release of at least one biologically active material. The sponge coating is made of a non-hydrogel polymer having a plurality of voids. The device can further include means for infusing or expelling the biologically active material or drug into the voids. The drug is delivered to the body lumen of a patient by expelling the drug and inflating or expanding the expandable portion of the catheter or device.

Abstract translation: 本发明的医疗装置包括可膨胀部分，其被海绵涂层覆盖以释放至少一种生物活性材料。 海绵涂层由具有多个空隙的非水凝胶聚合物制成。 该装置还可以包括用于将生物活性材料或药物注入或排出到空隙中的装置。 通过排出药物并使导管或装置的可扩张部分膨胀或膨胀，将药物输送到患者的体腔。

公开(公告)号：US07462165B2

公开(公告)日：2008-12-09

申请号：US10071400

申请日：2002-02-07

Applicant: Ni Ding ,  W. Scott Andrus

Inventor： Ni Ding ,  W. Scott Andrus

IPC: A61M29/00

CPC classification number: A61F2/86 ,  A61F2250/0068 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/236 ,  A61L2300/42 ,  A61L2300/606 ,  A61M25/104 ,  A61M2025/105 ,  A61M2025/1075 ,  A61M2025/1081

Abstract: The medical devices of the invention comprise an expandable portion which is covered with a sponge coating for release of at least one biologically active material. The sponge coating is made of a non-hydrogel polymer having a plurality of voids. The device can further include means for infusing or expelling the biologically active material or drug into the voids. The drug is delivered to the body lumen of a patient by expelling the drug and inflating or expanding the expandable portion of the catheter or device.

Abstract translation: 本发明的医疗装置包括可膨胀部分，其被海绵涂层覆盖以释放至少一种生物活性材料。 海绵涂层由具有多个空隙的非水凝胶聚合物制成。 该装置还可以包括用于将生物活性材料或药物注入或排出到空隙中的装置。 通过排出药物并使导管或装置的可扩张部分膨胀或膨胀，将药物输送到患者的体腔。

公开(公告)号：US07413746B2

公开(公告)日：2008-08-19

申请号：US11803810

申请日：2007-05-15

Applicant: Ni Ding

Inventor： Ni Ding

IPC: A61F

CPC classification number: A61K31/4745 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  B82Y30/00 ,  B82Y40/00 ,  Y10T428/24

Abstract: A coating for a medical device, particularly for a drug eluting stent, is described. The coating includes a self-assembled monolayer.

Abstract translation: 描述了用于医疗装置的涂层，特别是用于药物洗脱支架的涂层。 涂层包括自组装单层。

公开(公告)号：US20070298354A1

公开(公告)日：2007-12-27

申请号：US11820560

申请日：2007-06-19

Applicant: Ni Ding ,  Gene Michal ,  Stephen Pacetti

Inventor： Ni Ding ,  Gene Michal ,  Stephen Pacetti

IPC: G03C5/00 ,  A61F2/06

CPC classification number: A61L31/16 ,  A61L31/084 ,  A61L2300/606

Abstract: A carbon coating on a stent having a bioactive agent covalently attached thereto and methods of making the same are described.

Abstract translation: 描述了具有共价连接于其上的生物活性剂的支架上的碳涂层及其制备方法。

公开(公告)号：US20070218246A1

公开(公告)日：2007-09-20

申请号：US11803810

申请日：2007-05-15

Applicant: Ni Ding

Inventor： Ni Ding

IPC: B32B7/00 ,  B05D1/00

CPC classification number: A61K31/4745 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  B82Y30/00 ,  B82Y40/00 ,  Y10T428/24

Abstract: A coating for a medical device, particularly for a drug eluting stent, is described. The coating includes a self-assembled monolayer.

Abstract translation: 描述了用于医疗装置的涂层，特别是用于药物洗脱支架的涂层。 涂层包括自组装单层。

公开(公告)号：US07232573B1

公开(公告)日：2007-06-19

申请号：US10255911

申请日：2002-09-26

Applicant: Ni Ding

Inventor： Ni Ding

IPC: A61F2/00

CPC classification number: A61K31/4745 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  B82Y30/00 ,  B82Y40/00 ,  Y10T428/24

Abstract: A coating for a medical device, particularly for a drug eluting stent, is described. The coating includes a self-assembled monolayer.