公开(公告)号：US20060014204A1

公开(公告)日：2006-01-19

申请号：US11227816

申请日：2005-09-15

申请人： Nicholas Gale ,  O. Thurston ,  George Yancopoulos

发明人： Nicholas Gale ,  O. Thurston ,  George Yancopoulos

IPC分类号： C12Q1/68 ,  A61K39/395 ,  A61K38/18 ,  A61K48/00 ,  A61K31/70

CPC分类号： C07K16/2863 ,  A61K38/00 ,  A61K38/1866 ,  C07K14/515 ,  A61K2300/00

摘要： Methods of inducing formation of functional and organized lymphatic vessels are described. Specifically, the methods relate to using Tie2 agonists to induce formation of functional and organized lymphatic vessels. The methods also relate to treating defects, diseases, and disorders characterized by lymphatic vessel malfunction, disorganization, and damage.

摘要翻译： 描述了诱导功能性和有组织的淋巴管形成的方法。 具体地说，该方法涉及使用Tie2激动剂来诱导功能性和有组织的淋巴管的形成。 该方法还涉及治疗以淋巴管故障，紊乱和损伤为特征的缺陷，疾病和病症。

公开(公告)号：US20060134121A1

公开(公告)日：2006-06-22

申请号：US11264243

申请日：2005-10-31

申请人： Gavin Thurston ,  Nicholas Gale ,  Irene Noguera

发明人： Gavin Thurston ,  Nicholas Gale ,  Irene Noguera

IPC分类号： A61K48/00 ,  G01N33/574 ,  A61K39/395 ,  C07K16/30

CPC分类号： C07K14/705 ,  C07K2319/30 ,  G01N33/6893 ,  G01N2800/32

摘要： Methods for screening for agents capable of inhibiting Dll4 are provided, as well as therapeutic methods for treating Dll4-mediated conditions. More specifically, methods are provided for identifying agents capable of inhibiting blood vessel growth and formation, such as antibodies to human DLL4.

摘要翻译： 提供了能够抑制Dll4的药物筛选的方法，以及用于治疗Dll4介导的病症的治疗方法。 更具体地，提供了用于鉴定能够抑制血管生长和形成的药剂的方法，例如针对人类DLL4的抗体。

公开(公告)号：US20060107194A1

公开(公告)日：2006-05-18

申请号：US10990710

申请日：2004-11-17

申请人： Nicholas Gale

发明人： Nicholas Gale

IPC分类号： G06F17/21 ,  G06F17/24 ,  G06F3/00

CPC分类号： G06F17/241 ,  G06F9/4411 ,  H04L41/0806 ,  H04L41/082 ,  H04L41/0843 ,  H04L41/0879

摘要： A system and method provide for producing and/or implementing a virtual device enabled electronic document. The electronic document includes documentary information and one or more virtual device initiators corresponding to the same or different target devices, or further, to device systems. At least a portion of the documentary information and a corresponding virtual device initiator, in one embodiment, correspond to at least one device operation of the device. A user invoking a virtual device initiator, in one embodiment, causes a document system to configure and initiate a virtual device, or further, other system devices with which the virtual device may interact.

摘要翻译： 一种系统和方法提供用于产生和/或实现启用虚拟设备的电子文档。 电子文档包括文件信息和对应于相同或不同的目标设备的一个或多个虚拟设备启动器，或者还包括到设备系统。 在一个实施例中，文件信息的至少一部分和对应的虚拟设备启动器对应于设备的至少一个设备操作。 在一个实施例中，调用虚拟设备启动器的用户使得文档系统配置和发起虚拟设备，或者进一步与虚拟设备可以与之交互的其他系统设备。

公开(公告)号：US08048418B2

公开(公告)日：2011-11-01

申请号：US12435030

申请日：2009-05-04

申请人： Irene Noguera-Troise ,  Gavin Thurston ,  Nicholas Gale ,  Eric Smith

发明人： Irene Noguera-Troise ,  Gavin Thurston ,  Nicholas Gale ,  Eric Smith

IPC分类号： A61K39/395 ,  A61K38/16

CPC分类号： C07K14/705 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/22 ,  C07K16/28 ,  C07K2317/73 ,  C07K2319/30 ,  C12N2799/022 ,  C12N2799/027

摘要： Disclosed is a therapeutic method for inhibiting development or growth of tumors that are resistant to the blockade of delta-like ligand 4 (Dll4), or vascular endothelial growth factor (VEGF), or to other therapeutic agents, by administering the combination of Dll4 antagonist and VEGF antagonist. The combined administration of these two agents, concurrently or sequentially, exhibits synergistic effects on blood vessel development and growth, thereby more effectively inhibiting the tumor growth than an administration of either agent alone. The Dll4 antagonist can be an anti-Dll4 antibody or antibody fragment capable of inhibiting the binding of Dll4 to a Notch receptor, or a fusion protein comprising the extracellular domain of Dll4 or a soluble Notch receptor, or a fragment thereof, fused to a multimerizing component. The VEGF antagonist can be a VEGF trap, anti-VEGF antibody or antibody fragment capable of inhibiting the binding of VEGF to a VEGF receptor.

摘要翻译： 公开了通过施用Dll4拮抗剂的组合来抑制对阻滞δ-样配体4（Dll4）或血管内皮生长因子（VEGF）或其它治疗剂的抗性的肿瘤的发展或生长的治疗方法 和VEGF拮抗剂。 这两种试剂同时或相继地组合施用对血管发育和生长表现出协同作用，从而比单独施用任一试剂更有效地抑制肿瘤生长。 Dll4拮抗剂可以是能够抑制Dll4与Notch受体结合的抗Dll4抗体或抗体片段，或包含融合到多聚化的Dll4的细胞外结构域或其可溶性Notch受体或其片段的融合蛋白 零件。 VEGF拮抗剂可以是能够抑制VEGF与VEGF受体结合的VEGF陷阱，抗VEGF抗体或抗体片段。

公开(公告)号：US20090246199A1

公开(公告)日：2009-10-01

申请号：US12435030

申请日：2009-05-04

申请人： Irene Noguera-Troise ,  Gavin Thurston ,  Nicholas Gale ,  Eric Smith

发明人： Irene Noguera-Troise ,  Gavin Thurston ,  Nicholas Gale ,  Eric Smith

IPC分类号： A61K39/395 ,  A61K38/16

CPC分类号： C07K14/705 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/22 ,  C07K16/28 ,  C07K2317/73 ,  C07K2319/30 ,  C12N2799/022 ,  C12N2799/027

摘要： Disclosed is a therapeutic method for inhibiting development or growth of tumors that are resistant to the blockade of delta-like ligand 4 (Dll4), or vascular endothelial growth factor (VEGF), or to other therapeutic agents, by administering the combination of Dll4 antagonist and VEGF antagonist. The combined administration of these two agents, concurrently or sequentially, exhibits synergistic effects on blood vessel development and growth, thereby more effectively inhibiting the tumor growth than an administration of either agent alone. The Dll4 antagonist can be an anti-Dll4 antibody or antibody fragment capable of inhibiting the binding of Dll4 to a Notch receptor, or a fusion protein comprising the extracellular domain of Dll4 or a soluble Notch receptor, or a fragment thereof, fused to a multimerizing component. The VEGF antagonist can be a VEGF trap, anti-VEGF antibody or antibody fragment capable of inhibiting the binding of VEGF to a VEGF receptor.

摘要翻译： 公开了通过施用Dll4拮抗剂的组合来抑制对阻滞δ-样配体4（Dll4）或血管内皮生长因子（VEGF）或其它治疗剂的抗性的肿瘤的发展或生长的治疗方法 和VEGF拮抗剂。 这两种试剂同时或相继地组合施用对血管发育和生长表现出协同作用，从而比单独施用任一试剂更有效地抑制肿瘤生长。 Dll4拮抗剂可以是能够抑制Dll4与Notch受体结合的抗Dll4抗体或抗体片段，或包含融合到多聚化的Dll4的细胞外结构域或其可溶性Notch受体或其片段的融合蛋白 零件。 VEGF拮抗剂可以是能够抑制VEGF与VEGF受体结合的VEGF陷阱，抗VEGF抗体或抗体片段。

公开(公告)号：US20080107648A1

公开(公告)日：2008-05-08

申请号：US11639894

申请日：2006-12-15

申请人： Irene Noguera ,  Gavin Thurston ,  Nicholas Gale ,  Eric Smith

发明人： Irene Noguera ,  Gavin Thurston ,  Nicholas Gale ,  Eric Smith

IPC分类号： A61K39/395 ,  A61P43/00

CPC分类号： A61K39/0011 ,  A01K2267/0331 ,  C07K2319/30 ,  C12N2799/022 ,  C12N2799/027

摘要： A therapeutic method for inhibiting tumor development or growth, comprising administering an agent capable of inhibiting human delta-like ligand 4 (DII4) activity to a subject in need thereof. In one embodiment, the agent is an anti-DII4 antibody or antibody fragment capable of inhibiting the binding of DII4 to a Notch receptor. In another embodiment, the agent is a fusion protein comprising the extracellular domain of DII4 or a fragment or variant thereof, fused to a multimerizing component such as an Fc domain. The method of the invention is useful for inhibiting tumor growth, particularly in tumors which are not responsive to other therapeutic agents.

摘要翻译： 一种抑制肿瘤发展或生长的治疗方法，包括向有需要的受试者施用能够抑制人类δ-配体4（DII4）活性的药剂。 在一个实施方案中，所述试剂是能够抑制DII4与Notch受体结合的抗DII4抗体或抗体片段。 在另一个实施方案中，所述试剂是包含融合到多聚化组分如Fc结构域的DII4的细胞外结构域或其片段或变体的融合蛋白。 本发明的方法可用于抑制肿瘤生长，特别是在对其它治疗剂无反应的肿瘤中。