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    Nucleic acid encoding novel type-1 cytokine receptor GLM-R
    1.
    发明授权
    Nucleic acid encoding novel type-1 cytokine receptor GLM-R 失效
    编码新型1型细胞因子受体GLM-R的核酸

    公开(公告)号：US07303896B2

    公开(公告)日：2007-12-04

    申请号：US10373512

    申请日：2003-02-24

    申请人： Nico P. Ghilardi ,  Frederic J. de Sauvage ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin Gurney ,  William I. Wood

    发明人： Nico P. Ghilardi ,  Frederic J. de Sauvage ,  Audrey Goddard ,  Paul J. Godowski ,  J. Christopher Grimaldi ,  Austin Gurney ,  William I. Wood

    IPC分类号： C12P21/06

    CPC分类号： C07K14/7158

    摘要： The present invention is directed to novel polypeptides and variants thereof of GLM-R polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Also provided are methods for detecting agents that modulate the activity of GLM-R. Also provided are methods for diagnosing and for treating disorders characterized by the over or under abundance of monocytes or macrophages.

    摘要翻译： 本发明涉及GLM-R多肽的新型多肽及其变体以及编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 还提供了用于检测调节GLM-R的活性的试剂的方法。 还提供了用于诊断和治疗特征在于单核细胞或巨噬细胞过度或不丰富的疾病的方法。