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1.发明授权Nucleic acid molecules encoding beta-like glycoprotein hormone polypeptides and heterodimers thereof 失效编码β样糖蛋白激素多肽的核酸分子及其异源二聚体公开(公告)号：US07514239B2
公开(公告)日：2009-04-07
申请号：US09818954
申请日：2001-03-27
Applicant: Christopher J. R. Paszty , Jin Cao , Dimitry M. Danilenko , Jianhua Gong , David C. Hill
Inventor： Christopher J. R. Paszty , Jin Cao , Dimitry M. Danilenko , Jianhua Gong , David C. Hill
CPC classification number: G01N33/74 , A01K2217/05 , A61K35/12 , A61K38/00 , A61K48/00 , C07K14/575 , C07K14/59 , C07K16/26 , C07K2317/34 , G01N2333/59
Abstract: Novel β10 polypeptides and heterodimers thereof, and nucleic acid molecules encoding the same are disclosed. The invention also provides vectors, host cells, selective binding agents, and methods for producing β10 polypeptides and heterodimeric forms thereof, specifically α2/β10. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with β10 polypeptides and α2/β10 heterodimers or their respective binding agents.
Abstract translation: 公开了新颖的β10多肽及其异源二聚体及其编码的核酸分子。 本发明还提供载体，宿主细胞，选择性结合剂，以及用于产生β10多肽及其异二聚体形式，特别是α2/β10的方法。 还提供了用于治疗，诊断，改善或预防具有β10多肽和α2/β10异源二聚体或其各自结合剂的疾病的方法。
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公开(公告)号：US20130052159A1
公开(公告)日：2013-02-28
申请号：US13566760
申请日：2012-08-03
Applicant: Alexander R. Abbas , Nico P. Ghilardi , Zora Modrusan , Dimitry M. Danilenko , Frederic J. De Sauvage , Wenjun Ouyang , Patricia A. Valdez , Yan Zheng
Inventor： Alexander R. Abbas , Nico P. Ghilardi , Zora Modrusan , Dimitry M. Danilenko , Frederic J. De Sauvage , Wenjun Ouyang , Patricia A. Valdez , Yan Zheng
IPC: A61K38/20 , A61K39/395 , A61K38/17 , A61P31/12 , A61K48/00 , A61K31/00 , A61P1/00 , A61P31/04 , C07K14/54 , C07K14/435
CPC classification number: A61K38/191 , A61K38/1709 , A61K38/20 , A61K38/204 , Y02A50/473
Abstract: The present invention relates to compositions and methods for treatment of microbial disorder by modulation of the host immune response. More particularly, the present invention relates to compositions that mediate an anti-microbial immune response, and methods of treating a microbial infection using such compositions.
Abstract translation: 本发明涉及通过调节宿主免疫应答来治疗微生物病症的组合物和方法。 更具体地，本发明涉及介导抗微生物免疫应答的组合物，以及使用这些组合物治疗微生物感染的方法。
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公开(公告)号：US20090202475A1
公开(公告)日：2009-08-13
申请号：US12291380
申请日：2008-11-07
Applicant: Alexander R. Abbas , Nico P. Ghilardi , Zora Modrusan , Dimitry M. Danilenko , Frederic J. De Sauvage , Wenjun Ouyang , Patricia A. Valdez , Yan Zheng
Inventor： Alexander R. Abbas , Nico P. Ghilardi , Zora Modrusan , Dimitry M. Danilenko , Frederic J. De Sauvage , Wenjun Ouyang , Patricia A. Valdez , Yan Zheng
IPC: A61K38/20 , A61K38/16 , C12N5/00 , A61K38/02 , A61K31/7052 , A61K39/395 , A61P31/00 , C07K14/54 , C07K14/00
CPC classification number: A61K38/191 , A61K38/1709 , A61K38/20 , A61K38/204 , Y02A50/473
Abstract: The present invention relates to compositions and methods for treatment of microbial disorder by modulation of the host immune response. More particularly, the present invention relates to compositions that mediate an anti-microbial immune response, and methods of treating a microbial infection using such compositions.
Abstract translation: 本发明涉及通过调节宿主免疫应答来治疗微生物病症的组合物和方法。 更具体地，本发明涉及介导抗微生物免疫应答的组合物，以及使用这些组合物治疗微生物感染的方法。
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公开(公告)号：US20110280828A1
公开(公告)日：2011-11-17
申请号：US13112850
申请日：2011-05-20
Applicant: Alexander R. ABBAS , Nico P. Ghilardi , Zora Modrusan , Dimitry M. Danilenko , Frederic J. De Sauvage , Wenjun Ouyang , Patricia A. Valdez , Yan Zheng
Inventor： Alexander R. ABBAS , Nico P. Ghilardi , Zora Modrusan , Dimitry M. Danilenko , Frederic J. De Sauvage , Wenjun Ouyang , Patricia A. Valdez , Yan Zheng
CPC classification number: A61K38/191 , A61K38/1709 , A61K38/20 , A61K38/204 , Y02A50/473
Abstract: The present invention relates to compositions and methods for treatment of microbial disorder by modulation of the host immune response. More particularly, the present invention relates to compositions that mediate an anti-microbial immune response, and methods of treating a microbial infection using such compositions.
Abstract translation: 本发明涉及通过调节宿主免疫应答来治疗微生物病症的组合物和方法。 更具体地，本发明涉及介导抗微生物免疫应答的组合物，以及使用这些组合物治疗微生物感染的方法。
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Patent Agency Ranking
公开(公告)号：US20080057515A1
公开(公告)日：2008-03-06
申请号：US10448771
申请日：2003-05-28
Applicant: Christopher J. R. Paszty , Jin Cao , Dimitry M. Danilenko , Jianhua Gong , David C. Hill
Inventor： Christopher J. R. Paszty , Jin Cao , Dimitry M. Danilenko , Jianhua Gong , David C. Hill
IPC: G01N33/53 , C07H21/04 , C07K14/575
CPC classification number: G01N33/74 , A01K2217/05 , A61K35/12 , A61K38/00 , A61K48/00 , C07K14/575 , C07K14/59 , C07K16/26 , C07K2317/34 , G01N2333/59
Abstract: Novel β10 polypeptides and heterodimers thereof, and nucleic acid molecules encoding the same are disclosed. The invention also provides vectors, host cells, selective binding agents, and methods for producing β10 polypeptides and heterodimeric forms thereof, specifically α2/β10. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with β10 polypeptides and α2/β10 heterodimers or their respective binding agents.
Abstract translation: 公开了新颖的β10多肽及其异源二聚体及其编码的核酸分子。 本发明还提供载体，宿主细胞，选择性结合剂，以及用于产生β10多肽及其异二聚体形式，特别是α2/β10的方法。 还提供了用于治疗，诊断，改善或预防具有β10多肽和α2/β10异源二聚体或其各自结合剂的疾病的方法。
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公开(公告)号：US20080188417A1
公开(公告)日：2008-08-07
申请号：US12072855
申请日：2008-02-27
Applicant: Christopher J. R. Paszty , Jin Cao , Dimitry M. Danilenko , Jianhua Gong , David C. Hill
Inventor： Christopher J. R. Paszty , Jin Cao , Dimitry M. Danilenko , Jianhua Gong , David C. Hill
CPC classification number: G01N33/74 , A01K2217/05 , A61K35/12 , A61K38/00 , A61K48/00 , C07K14/575 , C07K14/59 , C07K16/26 , C07K2317/34 , G01N2333/59
Abstract: Novel β10 polypeptides and heterodimers thereof, and nucleic acid molecules encoding the same are disclosed. The invention also provides vectors, host cells, selective binding agents, and methods for producing β10 polypeptides and heterodimeric forms thereof, specifically α2/β10. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with β10 polypeptides and α2/β10 heterodimers or their respective binding agents.
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公开(公告)号：US07358341B2
公开(公告)日：2008-04-15
申请号：US10448771
申请日：2003-05-28
Applicant: Christopher J. R. Paszty , Jin Cao , Dimitry M. Danilenko , Jianhua Gong , David C. Hill
Inventor： Christopher J. R. Paszty , Jin Cao , Dimitry M. Danilenko , Jianhua Gong , David C. Hill
IPC: C07K14/575 , C07K14/59
CPC classification number: G01N33/74 , A01K2217/05 , A61K35/12 , A61K38/00 , A61K48/00 , C07K14/575 , C07K14/59 , C07K16/26 , C07K2317/34 , G01N2333/59
Abstract: Novel β10 polypeptides and heterodimers thereof, and nucleic acid molecules encoding the same are disclosed. The invention also provides vectors, host cells, selective binding agents, and methods for producing β10 polypeptides and heterodimeric forms thereof, specifically α2/β10. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with β10 polypeptides and α2/β10 heterodimers or their respective binding agents.
Abstract translation: 公开了新颖的β10多肽及其异源二聚体及其编码的核酸分子。 本发明还提供载体，宿主细胞，选择性结合剂，以及用于产生β10多肽及其异二聚体形式，特别是α2/β10的方法。 还提供了用于治疗，诊断，改善或预防具有β10多肽和α2/β10异源二聚体或其各自结合剂的疾病的方法。
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8.发明申请NUCLEIC ACID MOLECULES ENCODING BETA-LIKE GLYCOPROTEIN HORMONE POLYPEPTIDE AND HETERODIMER THEREOF 失效编码类似谷氨酸激素多聚核苷酸和其它杂环化合物的核酸分子公开(公告)号：US20100255537A1
公开(公告)日：2010-10-07
申请号：US12816475
申请日：2010-06-16
Applicant: Christopher J. R. Paszty , Jin Cao , Dimitry M. Danilenko , Jianhua Gong , David C. Hill
Inventor： Christopher J. R. Paszty , Jin Cao , Dimitry M. Danilenko , Jianhua Gong , David C. Hill
CPC classification number: G01N33/74 , A01K2217/05 , A61K35/12 , A61K38/00 , A61K48/00 , C07K14/575 , C07K14/59 , C07K16/26 , C07K2317/34 , G01N2333/59
Abstract: Novel β10 polypeptides and heterodimers thereof, and nucleic acid molecules encoding the same are disclosed. The invention also provides vectors, host cells, selective binding agents, and methods for producing β10 polypeptides and heterodimeric forms thereof, specifically α2/β10. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with β10 polypeptides and α2/β10 heterodimers or their respective binding agents.
Abstract translation: 公开了10种多肽及其异源二聚体及其编码的核酸分子。 本发明还提供了载体，宿主细胞，选择性结合剂，以及用于产生10种多肽及其异二聚体形式的方法，特别是α2 / bgr。 还提供了用于治疗，诊断，改善或预防具有10种多肽和α2/ bgr10异源二聚体或其各自结合剂的疾病的方法。
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9.发明申请Nucleic acid molecules encoding beta-like glycoprotein hormone polypeptide and heterodimer thereof 有权编码β样糖蛋白激素多肽的核酸分子及其异二聚体公开(公告)号：US20080166768A1
公开(公告)日：2008-07-10
申请号：US12072822
申请日：2008-02-27
Applicant: Chirstopher J. R. Paszty , Jin Cao , Dimitry M. Danilenko , Jianhua Gong , David C. Hill
Inventor： Chirstopher J. R. Paszty , Jin Cao , Dimitry M. Danilenko , Jianhua Gong , David C. Hill
CPC classification number: G01N33/74 , A01K2217/05 , A61K35/12 , A61K38/00 , A61K48/00 , C07K14/575 , C07K14/59 , C07K16/26 , C07K2317/34 , G01N2333/59
Abstract: Novel β10 polypeptides and heterodimers thereof, and nucleic acid molecules encoding the same are disclosed. The invention also provides vectors, host cells, selective binding agents, and methods for producing β10 polypeptides and heterodimeric forms thereof, specifically α2/β10. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with β10 polypeptides and α2/β10 heterodimers or their respective binding agents.
Abstract translation: 公开了新颖的β10多肽及其异源二聚体及其编码的核酸分子。 本发明还提供载体，宿主细胞，选择性结合剂，以及用于产生β10多肽及其异二聚体形式，特别是α2/β10的方法。 还提供了用于治疗，诊断，改善或预防具有β10多肽和α2/β10异源二聚体或其各自结合剂的疾病的方法。
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