专利检索 ap:("Nicole Buschmann" OR "Robin Alec Fairhurst" OR "Jorge Garcia Fortanet" OR "Pascal Furet" OR "Diana Graus Porta" OR "Nafeeza Hafeez" OR "Bo Han" OR "Thomas Knoepfel" OR "Matthew J. LaMarche" OR "Catherine Leblanc") AND inv:"Catherine Leblanc" 第 1 页

1.

发明申请
PHARMACEUTICAL COMBINATIONS 审中-公开

公开(公告)号：US20180064709A1

公开(公告)日：2018-03-08

申请号：US15561209

申请日：2016-03-23

申请人： Nicole Buschmann , Robin Alec Fairhurst , Jorge Garcia Fortanet , Pascal Furet , Diana Graus Porta , Nafeeza Hafeez , Bo Han , Thomas Knoepfel , Matthew J. LaMarche , Catherine Leblanc

发明人： Nicole Buschmann , Robin Alec Fairhurst , Jorge Garcia Fortanet , Pascal Furet , Diana Graus Porta , Nafeeza Hafeez , Bo Han , Thomas Knoepfel , Matthew J. LaMarche , Catherine Leblanc

IPC分类号： A61K31/496 , A61K31/497

CPC分类号： A61K31/496 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K2300/00

摘要： A pharmaceutical combination comprising N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide, or a pharmaceutically acceptable salt thereof, and at least one active ingredient, as defined herein, or a pharmaceutically acceptable salt thereof, and optionally a pharmaceutically acceptable carrier, for simultaneous or sequential administration; the uses of such combination in the treatment of proliferative diseases; and methods of treating a subject suffering from a proliferative disease comprising administering a therapeutically effective amount of such combination.

2.

发明申请
Formylated N-heterocyclic derivatives as FGFR4 inhibitors 审中-公开

公开(公告)号：US20180065951A1

公开(公告)日：2018-03-08

申请号：US15561189

申请日：2016-03-23

申请人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Thomas Knoepfel , Catherine Leblanc , Robert Mah

发明人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Thomas Knoepfel , Catherine Leblanc , Robert Mah

IPC分类号： C07D401/12 , C07D405/14 , C07D401/14

CPC分类号： C07D401/12 , A61K31/4427 , C07D213/75 , C07D401/14 , C07D405/14

摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.

3.

发明授权
Formylated N-heterocyclic derivatives as FGFR4 inhibitors 有权

公开(公告)号：US10189813B2

公开(公告)日：2019-01-29

申请号：US15561189

申请日：2016-03-23

申请人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Thomas Knoepfel , Catherine Leblanc , Robert Mah

发明人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Thomas Knoepfel , Catherine Leblanc , Robert Mah

IPC分类号： C07D401/12 , C07D401/14 , A61K31/4427 , C07D213/75 , C07D405/14

摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.

4.

发明申请
Ring-fused bicyclic pyridyl derivatives as FGFR4 inhibitors 审中-公开
标题翻译：环稠合的双环吡啶基衍生物作为FGFR4抑制剂

公开(公告)号：US20170066766A1

公开(公告)日：2017-03-09

申请号：US15357195

申请日：2016-11-21

申请人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Thomas Knöpfel , Catherine Leblanc , Lv Liao , Robert Mah , Pierre Nimsgern , Sebastien Ripoche , Jing Xiong , Bo Han , Can Wang , Xianglin Zhao

发明人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Thomas Knöpfel , Catherine Leblanc , Lv Liao , Robert Mah , Pierre Nimsgern , Sebastien Ripoche , Jing Xiong , Bo Han , Can Wang , Xianglin Zhao

IPC分类号： C07D471/04 , C07D519/00 , C07D498/04

CPC分类号： C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , C07D498/04 , C07D519/00

摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.

摘要翻译： 制备所述化合物的方法及其治疗用途。本发明还提供药理学活性剂和包含所述化合物的药物组合物的组合。

5.

发明申请
Ring-fused bicyclic pyridyl derivatives as FGFR4 inhibitors 审中-公开

公开(公告)号：US20160102092A1

公开(公告)日：2016-04-14

申请号：US14972984

申请日：2015-12-17

申请人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Thomas Knöpfel , Catherine Leblanc , Lv Liao , Robert Mah , Pierre Nimsgern , Sebastien Ripoche , Jing Xiong , Bo Han , Can Wang , Xianglin Zhao

发明人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Thomas Knöpfel , Catherine Leblanc , Lv Liao , Robert Mah , Pierre Nimsgern , Sebastien Ripoche , Jing Xiong , Bo Han , Can Wang , Xianglin Zhao

IPC分类号： C07D471/04 , C07D519/00 , C07D498/04

CPC分类号： C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , C07D498/04 , C07D519/00

摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.

6.

发明申请
Ring-fused bicyclic pyridyl derivatives as FGFR4 inhibitors 有权
标题翻译：环稠合的双环吡啶基衍生物作为FGFR4抑制剂

公开(公告)号：US20150119385A1

公开(公告)日：2015-04-30

申请号：US14522721

申请日：2014-10-24

申请人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Thomas Knöpfel , Catherine Leblanc , Lv Liao , Robert Mah , Pierre Nimsgern , Sebastien Ripoche , Jing Xiong , Bo Han , Can Wang , Xianglin Zhao

发明人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Thomas Knöpfel , Catherine Leblanc , Lv Liao , Robert Mah , Pierre Nimsgern , Sebastien Ripoche , Jing Xiong , Bo Han , Can Wang , Xianglin Zhao

IPC分类号： C07D471/04 , A61K31/506 , C07D498/04 , A61K31/55 , A61K31/497 , A61K31/5377 , C07D519/00 , A61K31/541 , A61K31/444 , A61K31/5383

CPC分类号： C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , C07D498/04 , C07D519/00

摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.

摘要翻译： 本发明提供式（I）化合物或其药学上可接受的盐; 制备所述化合物的方法及其治疗用途。本发明还提供药理学活性剂和包含所述化合物的药物组合物的组合。

7.

发明授权
Ring-fused bicyclic pyridyl derivatives as FGFR4 inhibitors 有权

公开(公告)号：US09896449B2

公开(公告)日：2018-02-20

申请号：US15357195

申请日：2016-11-21

申请人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Thomas Knöpfel , Catherine Leblanc , Lv Liao , Robert Mah , Pierre Nimsgern , Sebastien Ripoche , Jing Xiong , Bo Han , Can Wang , Xianglin Zhao

发明人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Thomas Knöpfel , Catherine Leblanc , Lv Liao , Robert Mah , Pierre Nimsgern , Sebastien Ripoche , Jing Xiong , Bo Han , Can Wang , Xianglin Zhao

IPC分类号： C07D519/00 , C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , C07D498/04

CPC分类号： C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , C07D498/04 , C07D519/00

摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.

8.

发明授权
Ring-fused bicyclic pyridyl derivatives as FGFR4 inhibitors 有权
标题翻译：环稠合的双环吡啶基衍生物作为FGFR4抑制剂

公开(公告)号：US09533988B2

公开(公告)日：2017-01-03

申请号：US14972984

申请日：2015-12-17

申请人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Thomas Knöpfel , Catherine Leblanc , Lv Liao , Robert Mah , Pierre Nimsgern , Sebastien Ripoche , Jing Xiong , Bo Han , Can Wang , Xianglin Zhao

发明人： Nicole Buschmann , Robin Alec Fairhurst , Pascal Furet , Thomas Knöpfel , Catherine Leblanc , Lv Liao , Robert Mah , Pierre Nimsgern , Sebastien Ripoche , Jing Xiong , Bo Han , Can Wang , Xianglin Zhao

IPC分类号： C07D471/04 , C07D498/04 , C07D519/00 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55

CPC分类号： C07D471/04 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , C07D498/04 , C07D519/00

摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.

摘要翻译： 本发明提供式（I）化合物或其药学上可接受的盐; 制备所述化合物的方法及其治疗用途。本发明还提供药理学活性剂和包含所述化合物的药物组合物的组合。