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1.发明授权Tissue ablation by shear force for sampling biological fluids and delivering active agents 有权通过剪切力进行组织消融，用于取样生物流体和递送活性剂公开(公告)号：US07404815B2
公开(公告)日：2008-07-29
申请号：US09845956
申请日：2001-04-30
申请人： Nikiforos Kollias , Ying Sun , Anthony F. Coston
发明人： Nikiforos Kollias , Ying Sun , Anthony F. Coston
IPC分类号： A61M31/00
CPC分类号： A61N1/303
摘要： The present invention relates to a method and a device for transporting a molecule through a mammalian barrier membrane of at least one layer of cells comprising the steps of: ablating said membrane with a shear device; and utilizing a driving force to move said molecule through said perforated membrane.
摘要翻译： 本发明涉及一种通过至少一层细胞的哺乳动物屏障膜输送分子的方法和装置，包括以下步骤：用剪切装置烧蚀所述膜; 并利用驱动力使所述分子移动穿过所述多孔膜。
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2.发明授权公开(公告)号：US07507228B2
公开(公告)日：2009-03-24
申请号：US10609708
申请日：2003-06-30
申请人： Ying Sun , Jue-Chen Liu , Jeffrey M. Wu , Nikiforos Kollias
发明人： Ying Sun , Jue-Chen Liu , Jeffrey M. Wu , Nikiforos Kollias
IPC分类号： A61M31/00
CPC分类号： A61N1/0428 , A61N1/044 , A61N1/0448
摘要： The present invention features a device having a barrier membrane contacting surface, the device containing: a power source; a first conductive electrode; a second conductive electrode; a first light emitting diode; and a carrier containing an active agent; wherein the power source is in electric communication with the first conductive electrode, the second conductive electrode, and the light emitting diode, and wherein the device is arranged such that light from the first light emitting diode and the carrier are in communication with the barrier membrane contacting surface.
摘要翻译： 本发明的特征在于具有阻挡膜接触表面的装置，该装置包括：电源; 第一导电电极; 第二导电电极; 第一发光二极管; 和含有活性剂的载体; 其中所述电源与所述第一导电电极，所述第二导电电极和所述发光二极管电连通，并且其中所述装置被布置成使得来自所述第一发光二极管和所述载体的光与所述阻挡膜连通 接触面。
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3.发明申请Tissue Ablation by Shear Force for Sampling Biological Fluids and Delivering Active Agents 审中-公开通过剪切力抽取生物流体和提供活性剂的组织消融公开(公告)号：US20090005659A1
公开(公告)日：2009-01-01
申请号：US12181192
申请日：2008-07-28
申请人： Nikiforos Kollias , Ying Sun , Coston Anthony F.
发明人： Nikiforos Kollias , Ying Sun , Coston Anthony F.
CPC分类号： A61N1/303
摘要： A shear device for use in transporting a molecule through a mammal's mammalian barrier membrane of at least one layer of cells includes a sheet containing an opening(s) and a shear member(s). The sheet is configured for contacting the mammalian barrier membrane (e.g., human skin) and the shear member is configured for ablating a portion of the mammalian barrier membrane forced through the opening(s). This ablating is accomplished by movement of the shear member(s) over the sheet and the opening(s). The ablation of the portion of the mammalian barrier membrane is such that a driving force can be employed to transport the molecule therethrough.
摘要翻译： 用于通过哺乳动物的至少一层细胞的哺乳动物屏障膜输送分子的剪切装置包括含有开口和剪切构件的片材。 该片被配置用于接触哺乳动物屏障膜（例如，人皮肤），并且剪切构件被配置用于烧蚀被迫穿过开口的哺乳动物屏障膜的一部分。 这种消融是通过剪切构件在片材和开口上的移动来实现的。 哺乳动物屏障膜部分的消融使得可以采用驱动力来输送分子。
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公开(公告)号：US20100262556A1
公开(公告)日：2010-10-14
申请号：US12820844
申请日：2010-06-22
申请人： Steven A. Shaya , Neal Matheson , John Anthony Singarayar , Nikiforos Kollias , Jeffrey Adam Bloom
发明人： Steven A. Shaya , Neal Matheson , John Anthony Singarayar , Nikiforos Kollias , Jeffrey Adam Bloom
CPC分类号： G06Q30/0631 , G06Q30/02 , G06Q30/0202 , G06Q30/0254 , G06Q30/0282 , G06Q30/0641
摘要： Systems and methods of utilizing communications networks and multivariate analysis to predict or recommend optimal products from a predefined population of commercially available products are disclosed. The recommendations are based on intelligence contained in processing elements and subjective and/or objective product information received from consumers or input to the systems as part of their initial setup. The output of the systems comprise sets of products that they predict the consumer will prefer and/or perform well for the problem or concern identified by the consumer. The performance and preference predictions are a function of consumer problems and product responsiveness patterns. Objective product information is generally obtained with diagnostic instruments. Data measured with the diagnostic instruments may be communicated to the data processing portions of the invention via the Internet. The outputs of the data processing portion of the system may be presented to consumers via the Internet as well.
摘要翻译： 公开了利用通信网络和多变量分析来预测或推荐来自预定义的市售产品群体的最佳产品的系统和方法。 这些建议是基于处理要素中包含的智能，以及从消费者收到的主观和/或客观的产品信息，或作为其初始设置的一部分输入到系统。 系统的输出包括他们预测消费者将更喜欢和/或对于消费者所识别的问题或关切而表现良好的产品集合。 性能和偏好预测是消费者问题和产品响应模式的函数。 客观的产品信息通常用诊断仪器获得。 用诊断仪器测量的数据可以经由因特网传送到本发明的数据处理部分。 系统的数据处理部分的输出也可以经由因特网向消费者呈现。
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公开(公告)号：US20100226861A1
公开(公告)日：2010-09-09
申请号：US12761461
申请日：2010-04-16
申请人： Curtis A. Cole , Nikiforos Kollias
发明人： Curtis A. Cole , Nikiforos Kollias
CPC分类号： A61Q17/04 , A61K8/02 , A61K2800/434 , A61K2800/438 , A61K2800/88 , G01N21/64
摘要： Compositions, devices, methods, and kits are provided for determining the presence of topical compositions on surfaces, such as skin.
摘要翻译： 提供组合物，装置，方法和试剂盒以确定表面如皮肤上局部组合物的存在。
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6.发明授权Imaging apparatus and methods for capturing and analyzing digital images of the skin 有权用于捕获和分析皮肤数字图像的成像设备和方法公开(公告)号：US07764303B2
公开(公告)日：2010-07-27
申请号：US11863342
申请日：2007-09-28
CPC分类号： H04N5/2354 , A61B5/0059 , A61B5/441 , G03B15/07 , H04N5/2252 , H04N9/045
摘要： An imaging station for taking a plurality of digital images of a subject under a plurality of illuminating conditions and storing and analyzing the digital images, includes a housing, containing the digital image capturing apparatus, like a camera or video recorder, a computer for processing the image data and one or more displays for displaying images of the person. The imaging station aids in controlling lighting during image capture and may be used to optimally position the subject for imaging. The computer may be programmed to conduct various image processing functions and may be networked to allow image sharing. A display which may be provided on the exterior of the housing allows an operator to visualize the subject and to control the imaging process. The imaging station may be used for teaching purposes.
摘要翻译： 一种用于在多个照明条件下拍摄对象的多个数字图像并存储和分析数字图像的成像站包括容纳数字图像捕获装置的外壳，如摄像机或录像机，用于处理 图像数据和用于显示人的图像的一个或多个显示器。 成像站有助于在图像捕获期间控制照明，并且可以用于最佳地定位被摄体以进行成像。 计算机可以被编程为执行各种图像处理功能，并且可以联网以允许图像共享。 可以设置在外壳的外部的显示器允许操作者可视化对象并控制成像处理。 成像站可用于教学目的。
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公开(公告)号：US20080080755A1
公开(公告)日：2008-04-03
申请号：US11863328
申请日：2007-09-28
申请人： Gregory Payonk , Nikiforos Kollias , Gabriela Cula
发明人： Gregory Payonk , Nikiforos Kollias , Gabriela Cula
IPC分类号： G06K11/00
CPC分类号： A61B5/0059 , A61B5/442 , G01J3/50
摘要： An apparatus and method for assessing photodamage has a digital imaging system for recording blue light imagining and in particular the green signal response intensity of the skin of a person, which is indicative of elastotic material and photodamage. Because the image data has a numerical intensity value, which may be expressed in RGB or L*a*b* colorspace, the image data taken from one image can be numerically compared to that of one or more other images and the image data is amenable to numerical and statistical analysis. Comparison to population profiles/image data permits an individual's image data to be characterized numerically, such as by a relative score or percentile rating. The image data can also be used to ascertain the degree of variation over a surface such as the face, with wider variation being indicative of greater photodamage.
摘要翻译： 用于评估光损伤的装置和方法具有用于记录蓝光想象的数字成像系统，特别是用于指示弹性材料和光损伤的人的皮肤的绿色信号响应强度。 由于图像数据具有可以以RGB或L * a * b *颜色空间表示的数值强度值，所以从一个图像获取的图像数据可以与一个或多个其他图像的图像数据进行数值比较，并且图像数据是可接受的 进行数值和统计分析。 与人口概况/图像数据的比较允许个人的图像数据以数字表示，例如通过相对评分或百分位数评级。 图像数据也可以用于确定诸如面部之类的表面上的变化程度，更广泛的变化指示更大的光损伤。
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8.发明申请Imaging Apparatus and Methods for Capturing and Analyzing Digital Images of the Skin 有权用于捕获和分析皮肤数字图像的成像装置和方法公开(公告)号：US20080079843A1
公开(公告)日：2008-04-03
申请号：US11863342
申请日：2007-09-28
CPC分类号： H04N5/2354 , A61B5/0059 , A61B5/441 , G03B15/07 , H04N5/2252 , H04N9/045
摘要： An imaging station for taking a plurality of digital images of a subject under a plurality of illuminating conditions and storing and analyzing the digital images, includes a housing, containing the digital image capturing apparatus, like a camera or video recorder, a computer for processing the image data and one or more displays for displaying images of the person. The imaging station aids in controlling lighting during image capture and may be used to optimally position the subject for imaging. The computer may be programmed to conduct various image processing functions and may be networked to allow image sharing. A display which may be provided on the exterior of the housing allows an operator to visualize the subject and to control the imaging process. The imaging station may be used for teaching purposes.
摘要翻译： 一种用于在多个照明条件下拍摄对象的多个数字图像并存储和分析数字图像的成像站包括容纳数字图像捕获装置的外壳，如摄像机或录像机，用于处理 图像数据和用于显示人的图像的一个或多个显示器。 成像站有助于在图像捕获期间控制照明，并且可以用于最佳地定位被摄体以进行成像。 计算机可以被编程为执行各种图像处理功能，并且可以联网以允许图像共享。 可以设置在外壳的外部的显示器允许操作者可视化对象并控制成像处理。 成像站可用于教学目的。
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公开(公告)号：US20070005393A1
公开(公告)日：2007-01-04
申请号：US11170297
申请日：2005-06-29
申请人： Curtis Cole , Nikiforos Kollias , Gregory Payonk
发明人： Curtis Cole , Nikiforos Kollias , Gregory Payonk
摘要： A system for conducting large scale clinical trials has a plurality of data collection nodes for collecting data from subjects participating in the clinical trial. A data analysis facility is located remotely from the data collection nodes and the data is communicated from the data collection nodes to the data analysis facility, where it is stored and analyzed. Each data collection node may include testing and data entry facilities, e.g., in the form of photographic equipment or various diagnostic and measuring probes, such as those used to measure skin color, elasticity and moisture content. The data nodes may be operated by the participant.
摘要翻译： 进行大规模临床试验的系统具有多个数据收集节点，用于收集参与临床试验的受试者的数据。 数据分析设备远离数据收集节点，数据从数据收集节点传送到数据分析设备，在那里进行存储和分析。 每个数据收集节点可以包括测试和数据输入设施，例如以照相设备或各种诊断和测量探针的形式，例如用于测量皮肤颜色，弹性和水分含量的那些。 数据节点可以由参与者操作。
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10.发明申请公开(公告)号：US20060268148A1
公开(公告)日：2006-11-30
申请号：US11497107
申请日：2006-08-01
IPC分类号： H04N5/225
CPC分类号： G03B29/00
摘要： The present invention relates to a method of photographing the skin of a person comprising: (i) illuminating the skin with at least one light source, wherein the light source emits substantially only light having a wavelength from about 380 to about 430 nm or emits light through a filter that emits substantially only light having a wavelength from about 380 to about 430 nm; and (ii) capturing the image of the illuminated skin with a camera; wherein the light entering the camera is also filtered with a long pass filter, wherein the long pass filter substantially eliminates light having a wavelength below about 400 nm.
摘要翻译： 本发明涉及拍摄人的皮肤的方法，包括：（i）用至少一个光源照射皮肤，其中光源基本上仅发射波长为约380至约430nm的光或发射光 通过基本上仅发射具有约380至约430nm的波长的光的滤光器; 和（ii）用相机拍摄照明皮肤的图像; 其中进入相机的光也用长通滤波器过滤，其中长通滤波器基本上消除波长低于约400nm的光。
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