公开(公告)号：US20200147242A1

公开(公告)日：2020-05-14

申请号：US16729470

申请日：2019-12-29

申请人： Ningxia Medical University

发明人： Guojing GOU ,  Min ZHANG ,  Xueqin JIN ,  Jianhong YANG ,  Huiqin YAO ,  Ling LI

IPC分类号： A61K49/00 ,  C09K11/89 ,  C09K11/02 ,  C08G81/02 ,  B01J13/08 ,  B01J13/22 ,  A61K41/00 ,  A61K31/513 ,  A61K9/107 ,  A61K47/34

摘要： A magnetic, thermosensitive, fluorescent micelle includes a core, a carrier wrapping the core, and a plurality of water-soluble near-infrared CdHgTe quantum dots (QD) disposed on the carrier. The core includes dextran-magnetic layered double hydroxide-fluorouracil (DMF). The carrier includes a tripolymer of poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide)-b-polylactic acid (PLA). N-isopropylacrylamide-co-N,N-dimethylacrylamide of the tripolymer includes a hydrophilic group and a hydrophobic carbon frame. The hydrophilic group is oriented outwards with respect to the and forms a shell. The hydrophobic carbon frame and polylactic acid are restrained to wrap the dextran-magnetic layered double hydroxide-fluorouracil to form the core.