公开(公告)号：US20220128439A1

公开(公告)日：2022-04-28

申请号：US17264408

申请日：2020-09-16

申请人： General Hospital of Ningxia Medical University

发明人： Yan XIE ,  Jiaxiang MA ,  Fang ZHAO ,  Xiaoliang PAN ,  Lifeng GUAN ,  Wei ZHOU

IPC分类号： G01N1/31 ,  G01N1/44

摘要： The disclosure describes a device and a method for high pressure and steaming heat-induced antigen retrieval. The device comprises a lower support mechanism, an isolation mechanism, a loading mechanism, a slide loading mechanism and a positioning mechanism, wherein the loading mechanism comprises at least two slide loading trays; the isolation mechanism comprises at least one upright post; and the at least two slide loading trays are sequentially arranged from bottom to top. The slide loading mechanism comprises at least one slice fixation box, and a slide glass and a cover glass arranged in the slice fixation box. The cover glass is placed on the upper surface of the slide glass, and the tissue to be retrieved is placed between the slide glass and the cover glass. A limiting hole is formed in the middle of the slide loading tray, and a plurality of air holes are formed in the slide loading tray.

公开(公告)号：US20240325478A1

公开(公告)日：2024-10-03

申请号：US18621062

申请日：2024-03-28

申请人： Ningxia Medical University ,  Ningxia Freedom Biological Pharmaceutical Technology Co., LTD

发明人： Rui He ,  Guangyong Li ,  Xiaojiang Chen ,  Xiaoli Du ,  Xiangdong Zhu ,  Huiming Ma ,  Miao Sun ,  Jiafuruzi He

IPC分类号： A61K36/232 ,  A61K36/076 ,  A61K36/185 ,  A61K36/235 ,  A61K36/236 ,  A61K36/24 ,  A61K36/284 ,  A61K36/344 ,  A61K36/48 ,  A61K36/481 ,  A61K36/484 ,  A61K36/54 ,  A61K36/62 ,  A61K36/67 ,  A61K36/714 ,  A61K36/754 ,  A61K36/894 ,  A61K36/9062 ,  A61K36/9068 ,  A61P15/08

CPC分类号： A61K36/232 ,  A61K36/076 ,  A61K36/185 ,  A61K36/235 ,  A61K36/236 ,  A61K36/24 ,  A61K36/284 ,  A61K36/344 ,  A61K36/48 ,  A61K36/481 ,  A61K36/484 ,  A61K36/54 ,  A61K36/62 ,  A61K36/67 ,  A61K36/714 ,  A61K36/754 ,  A61K36/894 ,  A61K36/9062 ,  A61K36/9068 ,  A61P15/08 ,  A61K2236/331

摘要： A traditional Chinese medicine compound for improving testicular dysfunction is made from the following raw materials: Codonopsis pilosula, Astragalus membranaceus, Dioscorea opposita, Angelica sinensis, Atractylodes macrocephala, Poria cocos, Cynanchum otophyllum, Psoralea corylifolia, Ligusticum chuanxiong, Nelumbo nucifera, Euryale ferox, Amomum villosum, Alpinia katsumadai, Foeniculum vulgare, Cinnamomum cassia, Evodia ruticarpa, Piper nigrum, Zingiber officinale, Aconitum carmichaelii, and Glycyrrhiza uralensis. All the raw materials are combined, so that the spleen, the stomach and the kidney are in harmony, the qi, the blood and the body fluid are recovered, and the kidney essence is active. Animal experiments show that the traditional Chinese medicine compound can up-regulate expressions of phosphatidylinositol 3-kinase (PI3K), phospho-protein kinase B (p-AKT) and B-cell lymphoma-2 (Bcl-2), improve testicular dysfunction, improve hormone secretion, regulate a male reproductive endocrine environment of the body, and further improve semen parameters.

公开(公告)号：US11911426B2

公开(公告)日：2024-02-27

申请号：US17344008

申请日：2021-06-10

申请人： Ningxia Medical University

发明人： Rui He ,  Guangyong Li ,  Puguang Yu ,  Yang Niu ,  Huiming Ma

IPC分类号： A61K36/185 ,  A61P5/24 ,  A61P5/30 ,  A61P15/08

CPC分类号： A61K36/185 ,  A61P5/24 ,  A61P5/30 ,  A61P15/08

摘要： The disclosure provides the use of a plant in the preparation of medicines and health products for preventing and treating ovarian injury. The application found that seabuckthorn fruit pulp and seabuckthorn seed oil have good preventive and therapeutic effects on ovarian injury. Seabuckthorn fruit pulp and seabuckthorn seed oil can prevent mouse ovarian injury and estrus cycle disorders, and can improve ovarian reserve, etc. Meanwhile, they also have good therapeutic effects on the above-mentioned injuries. This application provides a basis for the prevention and treatment of ovarian injury directly by seabuckthorn fruit pulp and seabuckthorn seed oil.

公开(公告)号：US20210386810A1

公开(公告)日：2021-12-16

申请号：US17344008

申请日：2021-06-10

申请人： Ningxia Medical University

发明人： Rui He ,  Guangyong Li ,  Puguang Yu ,  Yang Niu ,  Huiming Ma

IPC分类号： A61K36/185 ,  A61P15/08 ,  A61P5/24 ,  A61P5/30

摘要： The disclosure provides the use of a plant in the preparation of medicines and health products for preventing and treating ovarian injury. The application found that seabuckthorn fruit pulp and seabuckthorn seed oil have good preventive and therapeutic effects on ovarian injury. Seabuckthorn fruit pulp and seabuckthorn seed oil can prevent mouse ovarian injury and estrus cycle disorders, and can improve ovarian reserve, etc. Meanwhile, they also have good therapeutic effects on the above-mentioned injuries. This application provides a basis for the prevention and treatment of ovarian injury directly by seabuckthorn fruit pulp and seabuckthorn seed oil.

公开(公告)号：US20210371814A1

公开(公告)日：2021-12-02

申请号：US17211866

申请日：2021-03-25

申请人： Ningxia Medical University

发明人： Xiuying PEI ,  Xiaoli YU ,  Yikai QIU ,  Ji WU ,  Jianqiang YU ,  Yanrong WANG ,  Xinrui LIU ,  Jing PU

IPC分类号： C12N5/075

摘要： Use of Cistanche deserticola polysaccharide (CDP) in promoting the proliferation and differentiation of female germline stem cells (FGSCs) is provided. Specifically, the addition of CDP in an in vitro cultivation system can promote the proliferation and differentiation of FGSCs, and especially can enhance the in vitro directed differentiation of FGSCs into oocytes, which provides a new research reference for studying the generation of oocytes in vivo and in vitro and also brings a new hope for research on physiological infertility.

公开(公告)号：US11007196B1

公开(公告)日：2021-05-18

申请号：US16844037

申请日：2020-04-09

申请人： Ningxia Medical University

发明人： Guojing Gou ,  Xueqin Jin ,  Rui Wang ,  Qinyu Pei ,  Huiqin Yao ,  Yumei Zhang ,  Lingxia Zuo

IPC分类号： A61K31/513 ,  C09K11/89 ,  A61K9/16 ,  B82Y15/00 ,  B82Y5/00

摘要： A method for preparing a composition of matter, the method including: 1) mixing a Zn(NO3)2 solution, a Hg(NO3)2 solution, and a mercaptopropionic acid solution, thereby yielding a precursor solution of Zn2+—Hg2+-mercaptopropionic acid; dissolving a selenium powder and a NaBH4 solid in water thereby yielding a NaHSe slurry; mixing the precursor solution and the NaHSe slurry thereby yielding zinc-mercury-selenium (ZnHgSe) quantum dot; 2) preparing a drug delivery system including dextran-magnetic layered double hydroxide-fluorouracil (DMF); binding the drug delivery system and the ZnHgSe quantum dot in a mass ratio of 1:1-3; and grinding the drug delivery system including the ZnHgSe quantum dot (QD) thereby yielding powders; and 3) dissolving the powders in absolute ethyl alcohol thereby yielding a first suspension; ultrasonically dispersing the first suspension thereby yielding a second suspension, magnetically separating the second suspension thereby yielding a solid product, centrifuging and washing the solid product.

公开(公告)号：US11827901B2

公开(公告)日：2023-11-28

申请号：US17211866

申请日：2021-03-25

申请人： Ningxia Medical University

发明人： Xiuying Pei ,  Xiaoli Yu ,  Yikai Qiu ,  Ji Wu ,  Jianqiang Yu ,  Yanrong Wang ,  Xinrui Liu ,  Jing Pu

IPC分类号： C12N5/075

CPC分类号： C12N5/0609 ,  C12N2500/32 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/13 ,  C12N2501/235 ,  C12N2501/90 ,  C12N2506/04

摘要： Use of Cistanche deserticola polysaccharide (CDP) in promoting the proliferation and differentiation of female germline stem cells (FGSCs) is provided. Specifically, the addition of CDP in an in vitro cultivation system can promote the proliferation and differentiation of FGSCs, and especially can enhance the in vitro directed differentiation of FGSCs into oocytes, which provides a new research reference for studying the generation of oocytes in vivo and in vitro and also brings a new hope for research on physiological infertility.

公开(公告)号：US20200147242A1

公开(公告)日：2020-05-14

申请号：US16729470

申请日：2019-12-29

申请人： Ningxia Medical University

发明人： Guojing GOU ,  Min ZHANG ,  Xueqin JIN ,  Jianhong YANG ,  Huiqin YAO ,  Ling LI

IPC分类号： A61K49/00 ,  C09K11/89 ,  C09K11/02 ,  C08G81/02 ,  B01J13/08 ,  B01J13/22 ,  A61K41/00 ,  A61K31/513 ,  A61K9/107 ,  A61K47/34

摘要： A magnetic, thermosensitive, fluorescent micelle includes a core, a carrier wrapping the core, and a plurality of water-soluble near-infrared CdHgTe quantum dots (QD) disposed on the carrier. The core includes dextran-magnetic layered double hydroxide-fluorouracil (DMF). The carrier includes a tripolymer of poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide)-b-polylactic acid (PLA). N-isopropylacrylamide-co-N,N-dimethylacrylamide of the tripolymer includes a hydrophilic group and a hydrophobic carbon frame. The hydrophilic group is oriented outwards with respect to the and forms a shell. The hydrophobic carbon frame and polylactic acid are restrained to wrap the dextran-magnetic layered double hydroxide-fluorouracil to form the core.

公开(公告)号：US20230381122A1

公开(公告)日：2023-11-30

申请号：US18318192

申请日：2023-05-16

申请人： NINGXIA MEDICAL UNIVERSITY

发明人： XUEQIN MA ,  YINGLI WANG

IPC分类号： A61K31/165 ,  A61K9/00 ,  A61P25/20 ,  A23L33/105

CPC分类号： A61K31/165 ,  A61K9/0056 ,  A61P25/20 ,  A23L33/105

摘要： An application of N1-dihydrocaffeoyl-N10-caffeoylspermidine in preparation of a drug, health product or functional food is disclosed. It belongs to the technical field of pharmaceutical chemistry. In the dose range of 2-100 mg/kg given to experimental animals, N1-dihydrocaffeoyl-N10-caffeoylspermidine can significantly reduce the number of activities, shorten the sleep latency and prolong the sleep duration of mice with insomnia, and at the same time, it can significantly regulate back the indicator levels of neurotransmitters such as 5-HT, 5-HIAA, GABA and Glu in the brain tissues of mice with insomnia. All of the above confirm that N1-dihydrocaffeoyl-N10-caffeoylspermidine have a sedative hypnotic effect and can be applied for the prevention and treatment of psychiatric disorders such as insomnia, anxiety and depression.