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1.发明申请公开(公告)号：US20200329684A1
公开(公告)日：2020-10-22
申请号：US16846718
申请日：2020-04-13
发明人： Takashi Okada , Tsutomu Igarashi , Asaka Shiozawa
IPC分类号： A01K67/027
摘要： Retinal detachment sometimes occurs during the aging process of retinal degeneration 6 model mouse (rd6 model mouse). The present invention provides a method for obtaining a retinal degeneration (rd) model mouse having a low risk of causing retinal detachment, including: acquiring tissue data about a retinal tissue in an rd model mouse by using a retinal examination means; determining whether or not the tissue data meets an evaluation criterion; and selecting the rd model mouse, the tissue data of which meets the evaluation criterion.
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公开(公告)号：US11845952B2
公开(公告)日：2023-12-19
申请号：US16968397
申请日：2019-01-16
发明人： Takashi Okada , Tsutomu Igarashi , Asaka Shiozawa
IPC分类号： C12N15/861 , A61P27/02 , A61K35/761 , A61K38/18 , A61K39/235
CPC分类号： C12N15/861 , A61K35/761 , A61K38/1833 , A61K39/235 , A61P27/02
摘要： One disadvantage of adeno-associated virus (AAV) is low gene expression efficiency due to delayed expression of the inserted gene. Provided is a vector plasmid for producing a vector genome to be inserted into an adeno-associated virus (AAV). The vector plasmid is provided with a vector genome cassette as a template of the vector genome, and the vector genome cassette is provided with: (1) an expression cassette including a nucleic acid molecule encoding a target gene and (b) a nucleic acid molecule encoding an expression regulatory region that allows expression of the target gene; and (2) two nucleic acid molecules positioned on both sides of the expression cassette and encoding inverted terminal repeats (ITRs). Also provided is a pharmaceutical composition containing the AVV vector, for treating or preventing an eye disease or disease associated with same. Further provided is a method for treating or preventing the eye disease or disease associated with same, comprising administering a therapeutically effective amount of the pharmaceutical composition for treating or preventing the eye disease or disease associated with same to a subject suffering from the eye disease or disease associated with same.
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