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公开(公告)号：US20220127606A1
公开(公告)日：2022-04-28
申请号：US17310239
申请日：2020-01-29
发明人： Takashi Okada , Hiromi KINOH , Yoshitsugu AOKI , Shin'ichi TAKEDA
IPC分类号： C12N15/113 , A61P21/04 , A61K47/64 , A61K9/10 , A61K9/14
摘要： Provided are a complex that comprises a nucleic acid-containing nanoparticle and a hollow particle of a non-enveloped virus, a method for producing the complex, and a pharmaceutical composition comprising the complex.
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公开(公告)号：US20210087560A1
公开(公告)日：2021-03-25
申请号：US16967483
申请日：2019-02-06
申请人： NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY , NIPPON MEDICAL SCHOOL FOUNDATION , DAIICHI SANKYO COMPANY, LIMITED
发明人： Ken Inoue , Heng Li , Takashi Okada , Yu Ohki , Makoto Koizumi
IPC分类号： C12N15/113 , C12N15/86
摘要： An object of the present invention is to provide a vector capable of oligodendrocyte-specifically suppressing expression of the PLP1 gene for treating PMD caused by abnormality of the PLP1 gene, and a promoter and miRNA therefor, and a pharmaceutical composition comprising the vector. The oligodendrocyte-specific promoter of the present invention comprises a nucleic acid having a sequence identity of at least 90% to a nucleotide sequence set forth in SEQ ID NO: 1. The miRNA of the present invention specific to the PLP1 gene comprises a pair of nucleotide sequences consisting of a specific antisense sequence and sense sequence.
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3.发明申请公开(公告)号：US20200329684A1
公开(公告)日：2020-10-22
申请号：US16846718
申请日：2020-04-13
发明人： Takashi Okada , Tsutomu Igarashi , Asaka Shiozawa
IPC分类号： A01K67/027
摘要： Retinal detachment sometimes occurs during the aging process of retinal degeneration 6 model mouse (rd6 model mouse). The present invention provides a method for obtaining a retinal degeneration (rd) model mouse having a low risk of causing retinal detachment, including: acquiring tissue data about a retinal tissue in an rd model mouse by using a retinal examination means; determining whether or not the tissue data meets an evaluation criterion; and selecting the rd model mouse, the tissue data of which meets the evaluation criterion.
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公开(公告)号：US20200289856A1
公开(公告)日：2020-09-17
申请号：US16651372
申请日：2018-09-18
发明人： Rei OGAWA , Hidenori SUZUKI , Atsushi SAKAI , Nao WAKABAYASHI , Hiroya TAKADA , Takayuki HOSHI
IPC分类号： A61N7/00
摘要： An ultrasonic therapy apparatus includes a plurality of ultrasonic transducers, a processor that identifies a position of an affected part and determines a focal point of ultrasonic waves radiated by the plurality of ultrasonic transducers based on the determined position of the affected part, and a drive circuit that generates a drive signal for driving the plurality of ultrasonic transducers at individual timings so that the ultrasonic waves are focused at the determined focal point.
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公开(公告)号：US20200284792A1
公开(公告)日：2020-09-10
申请号：US16645225
申请日：2018-09-07
发明人： Yoshiko IWAI , Masahiro TAKEUCHI , Tomomitsu DOI
IPC分类号： G01N33/569 , G01N33/543
摘要： The present invention aims to develop a method capable of evaluating T cell immune function. A method for evaluating T cell immune function including detecting and quantifying soluble PD-L1 having a binding ability to PD-1, and an ELISA system used for detecting and quantifying bsPD-L1, including a carrier with a solid-phased PD-1 protein, a means for reacting the carrier and a test sample, and a means for detecting and m quantifying soluble PD-L1 bound to the carrier as bsPD-L1.
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公开(公告)号：US20210246173A1
公开(公告)日：2021-08-12
申请号：US17244106
申请日：2021-04-29
申请人： NIPPON MEDICAL SCHOOL FOUNDATION , NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY , TAKARA BIO INC.
发明人： Takashi OKADA , Hironori OKADA , Hiromi KINOH , Tatsuji ENOKI , Toshikazu NISHIE , Junichi MINENO
IPC分类号： C07K14/005 , C12N7/00 , C12N15/85
摘要： The present invention provides: a mutant of adeno-associated virus (AAV) capsid protein, which contains at least one amino acid substitution in PLA2 domain when compared with the amino acid sequence for wild-type AAV capsid protein; a nucleic acid encoding the mutant; a cell containing the nucleic acid; a method for producing a recombinant AAV particle, comprising a step of culturing the cell to produce the recombinant AAV particle; a recombinant AAV particle containing the mutant; a composition containing the recombinant AAV particle; and a method for transferring a gene into a target cell, comprising a step of bringing the recombinant AAV particle into contact with the target cell.
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公开(公告)号：US20210228205A1
公开(公告)日：2021-07-29
申请号：US17059328
申请日：2019-05-30
发明人： Ryu NAKADATE , Susumu OGURI , Makoto HASHIZUME , Akio MORITA
IPC分类号： A61B17/04 , A61B17/062
摘要： An automatic needle mover (1) for moving a medical threaded needle includes: two shafts (a first shaft (11) and a second shaft (12)) extending in the same direction and slidable relative to each other along a longitudinal direction; a needle holding portion (a second needle support portion (22)) provided on one end side of the second shaft (12); a needle-receiving portion (a first needle support portion (21)) provided on one end side of the first shaft (11); and a handle (30) serving as a control portion for controlling the sliding of the two shafts. The needle holding portion has a first groove portion provided in a first claw portion protruding in a direction intersecting the longitudinal direction of the shafts. The needle-receiving portion has a second groove portion provided in a second claw portion protruding in a direction intersecting the longitudinal direction of the shafts. As a result of the sliding of the two shafts, the needle holding portion and the needle-receiving portion become close to each other and a straight needle held by the needle holding portion can be press-fitted into the needle receiving portion.
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公开(公告)号：US20210205285A1
公开(公告)日：2021-07-08
申请号：US15998949
申请日：2017-02-17
申请人： NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY , Nippon Medical School Foundation , Teijin Phama Limited
发明人： Takeshi NISHINO , Shinsuke KATO , Masako KATO , Hidenori SUZUKI , Ken OKAMOTO
IPC分类号： A61K31/4439 , A61P25/28 , A61K31/426 , A61K31/427 , A61K9/00
摘要： The present invention provides a therapeutic agent or a prophylactic agent of dementia containing xanthine oxidase inhibitor such as a compound represented in formula (I), (II), (III) or (IV), or a pharmaceutically acceptable salt thereof as an active ingredient.
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公开(公告)号：US20180117047A1
公开(公告)日：2018-05-03
申请号：US15548550
申请日：2016-02-23
申请人： NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY , NIPPON MEDICAL SCHOOL FOUNDATION , NIPPON CHEMIPHAR CO., LTD.
发明人： Takeshi NISHINO , Shinsuke KATO , Masako KATO , Hidenori SUZUKI , Ken OKAMOTO
IPC分类号： A61K31/519 , A61P25/28
CPC分类号： A61K31/519 , A61K31/403 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/4355 , A61K31/4365 , A61K31/437 , A61P25/28
摘要： A medicament for prophylactic and/or therapeutic treatment of dementia, which comprises a compound represented by the formula (I) having a xanthine oxidase inhibitory action as an active ingredient.
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公开(公告)号：US11627956B2
公开(公告)日：2023-04-18
申请号：US17059328
申请日：2019-05-30
发明人： Ryu Nakadate , Susumu Oguri , Makoto Hashizume , Akio Morita
IPC分类号： A61B17/04 , A61B17/062
摘要： An automatic needle mover for moving a medical threaded needle includes: two shafts extending in the same direction and slidable relative to each other along a longitudinal direction; a needle-holding portion provided on one end side of the second shaft; a needle-receiving portion provided on one end side of the first shaft; and a handle serving as a control portion for controlling the sliding of the two shafts. The needle-holding portion has a first claw portion protruding in a direction intersecting the longitudinal direction of the shafts. The needle-receiving portion has a second claw portion protruding in a direction intersecting the longitudinal direction of the shafts. As a result of the sliding of the two shafts, the needle-holding portion and the needle-receiving portion become close to each other and a straight needle held by the needle-holding portion can be press-fitted into the needle-receiving portion.
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