公开(公告)号：US20060293219A1

公开(公告)日：2006-12-28

申请号：US11424295

申请日：2006-06-15

申请人： Nnochiri Ekwuribe ,  Christopher Price ,  James Still ,  Jennifer Filbey ,  Aslam Ansari ,  Amy Odenbaugh ,  Balasingam Radhakrishnan

发明人： Nnochiri Ekwuribe ,  Christopher Price ,  James Still ,  Jennifer Filbey ,  Aslam Ansari ,  Amy Odenbaugh ,  Balasingam Radhakrishnan

IPC分类号： A61K38/28

CPC分类号： C07K14/62 ,  A61K38/28 ,  A61K47/542 ,  A61K47/60

摘要： Methods of treating diabetes mellitus in a patient in need of such treatment include administering an effective amount of an insulin drug to the patient in order to treat diabetes mellitus in the patient. Methods according to the present invention may “activate” the liver, potentially restoring normal glucose homeostasis to individuals suffering from diabetes mellitus.

摘要翻译： 在需要这种治疗的患者中治疗糖尿病的方法包括向患者施用有效量的胰岛素药物以治疗患者的糖尿病。 根据本发明的方法可以“激活”肝脏，潜在地恢复患有糖尿病的个体的正常葡萄糖体内平衡。

公开(公告)号：US20060199759A1

公开(公告)日：2006-09-07

申请号：US11417586

申请日：2006-05-04

申请人： Nnochiri Ekwuribe ,  Christopher Price ,  Aslam Ansari ,  Balasingam Radhakrishnan ,  Amy Odenbaugh

发明人： Nnochiri Ekwuribe ,  Christopher Price ,  Aslam Ansari ,  Balasingam Radhakrishnan ,  Amy Odenbaugh

IPC分类号： A61K38/28 ,  C07K14/62

CPC分类号： A61K38/28 ,  A61K45/06 ,  A61K47/60

摘要： A mixture of conjugates in which each conjugate in the mixture comprises an insulin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may exhibit higher in vivo activity than a polydispersed mixture of similar conjugates. The mixture may also be more effective at surviving an in vitro model of intestinal digestion than polydispersed mixtures of similar conjugates. The mixture may also result in less inter-subject variability than polydispersed mixtures of similar conjugates.

公开(公告)号：US20060100137A1

公开(公告)日：2006-05-11

申请号：US11314309

申请日：2005-12-21

申请人： Nnochiri Ekwuribe ,  Christopher Price ,  James Still ,  Jennifer Filbey ,  Aslam Ansari ,  Amy Odenbaugh ,  Balasingam Radhakrishnan

发明人： Nnochiri Ekwuribe ,  Christopher Price ,  James Still ,  Jennifer Filbey ,  Aslam Ansari ,  Amy Odenbaugh ,  Balasingam Radhakrishnan

IPC分类号： A61K38/28 ,  C07K14/62

CPC分类号： C07K14/62 ,  A61K38/28 ,  A61K47/542 ,  A61K47/60

摘要： Methods of treating diabetes mellitus in a patient in need of such treatment include administering an effective amount of an insulin drug to the patient in order to treat diabetes mellitus in the patient. Methods according to the present invention may “activate” the liver, potentially restoring normal glucose homeostasis to individuals suffering from diabetes mellitus.

公开(公告)号：US20050059799A1

公开(公告)日：2005-03-17

申请号：US10977973

申请日：2004-10-29

申请人： Nnochiri Ekwuribe ,  Christopher Price ,  Aslam Ansari ,  Amy Odenbaugh

发明人： Nnochiri Ekwuribe ,  Christopher Price ,  Aslam Ansari ,  Amy Odenbaugh

IPC分类号： C07C41/16 ,  C07C43/13 ,  C08G65/08 ,  C08G65/334 ,  C08L71/02 ,  C12N5/00

CPC分类号： C08G65/334 ,  C08L71/02 ,  C08L71/00

摘要： Methods of synthesizing a substantially monodispersed mixture of polymers comprising polyethylene glycol moieties include: reacting a substantially monodispersed mixture of compounds having the structure of Formula I: R1(OC2H4)b—O−X+  (I) wherein R1 is H or a lipophilic moiety; n is from 1 to 25; and X+ is a positive ion, with a substantially monodispersed mixture of compounds having the structure of Formula II: R2(OC2H4)m—OMs   (II) wherein R2 is H or a lipophilic moiety; and m is from 1 to 25, under conditions sufficient to provide a substantially monodispersed mixture of polymers comprising polyethylene glycol moieties and having the structure of Formula III: R2(OC2H4)m+n—OR1   (III). Substantially monodispersed mixtures of polymers comprising polyethylene glycol moieties are also disclosed.

摘要翻译： 合成包含聚乙二醇部分的聚合物的基本上单分散的混合物的方法包括：使具有式I结构的化合物的基本上单分散的混合物：R 1（OC 2 H 4）b O - X +（I） 1>是H或亲脂性部分; n为1至25; 并且X +是具有式II结构的化合物的基本上单分散的混合物：R 2（OC 2 H 4）m-OM（II）其中R 2是H或亲油部分; 并且m为1至25，在足以提供包含聚乙二醇部分并且具有式III结构的基本单分散混合物的条件下：R 2（OC 2 H 4）m + n -OR 1（III）。 还公开了包含聚乙二醇部分的聚合物的基本上单分散的混合物。

公开(公告)号：US20140100178A1

公开(公告)日：2014-04-10

申请号：US13645436

申请日：2012-10-04

申请人： Aslam Ansari ,  Sanjay Gupta

发明人： Aslam Ansari ,  Sanjay Gupta

IPC分类号： A61K47/48

CPC分类号： A61K47/549

摘要： A system for selectively delivering drugs to target tissues is provided. The system includes a drug-linker-saccharide-drug conjugate (D-L-A-D1). The linker includes a functional group that is recognized and cleaved by enzyme in the target phases. The recognition segment is preferably a malaria drugs. The carrier is preferably hydrophilic, biodegradable and biocompatible particle. Any drug may be delivered using a conjugate prepared according to the invention.

摘要翻译： 提供了一种用于选择性地将药物输送到靶组织的系统。 该系统包括药物 - 接头 - 糖 - 药物共轭物（D-L-A-D1）。 连接体包括在靶相中被酶识别和切割的官能团。 识别部分优选为疟疾药物。 载体优选是亲水的，可生物降解的和生物相容性的颗粒。 可以使用根据本发明制备的缀合物递送任何药物。