摘要:
Methods of synthesizing a substantially monodispersed mixture of polymers comprising polyethylene glycol moieties include: reacting a substantially monodispersed mixture of compounds having the structure of Formula I: R1(OC2H4)b—O−X+ (I) wherein R1 is H or a lipophilic moiety; n is from 1 to 25; and X+ is a positive ion, with a substantially monodispersed mixture of compounds having the structure of Formula II: R2(OC2H4)m—OMs (II) wherein R2 is H or a lipophilic moiety; and m is from 1 to 25, under conditions sufficient to provide a substantially monodispersed mixture of polymers comprising polyethylene glycol moieties and having the structure of Formula III: R2(OC2H4)m+n—OR1 (III). Substantially monodispersed mixtures of polymers comprising polyethylene glycol moieties are also disclosed.
摘要翻译:合成包含聚乙二醇部分的聚合物的基本上单分散的混合物的方法包括:使具有式I结构的化合物的基本上单分散的混合物:R 1(OC 2 H 4)b O - X +(I) 1>是H或亲脂性部分; n为1至25; 并且X +是具有式II结构的化合物的基本上单分散的混合物:R 2(OC 2 H 4)m-OM(II)其中R 2是H或亲油部分; 并且m为1至25,在足以提供包含聚乙二醇部分并且具有式III结构的基本单分散混合物的条件下:R 2(OC 2 H 4)m + n -OR 1(III)。 还公开了包含聚乙二醇部分的聚合物的基本上单分散的混合物。
摘要:
Methods of treating diabetes mellitus in a patient in need of such treatment include administering an effective amount of an insulin drug to the patient in order to treat diabetes mellitus in the patient. Methods according to the present invention may “activate” the liver, potentially restoring normal glucose homeostasis to individuals suffering from diabetes mellitus.
摘要:
A mixture of conjugates in which each conjugate in the mixture comprises an insulin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may exhibit higher in vivo activity than a polydispersed mixture of similar conjugates. The mixture may also be more effective at surviving an in vitro model of intestinal digestion than polydispersed mixtures of similar conjugates. The mixture may also result in less inter-subject variability than polydispersed mixtures of similar conjugates.
摘要:
Methods of treating diabetes mellitus in a patient in need of such treatment include administering an effective amount of an insulin drug to the patient in order to treat diabetes mellitus in the patient. Methods according to the present invention may “activate” the liver, potentially restoring normal glucose homeostasis to individuals suffering from diabetes mellitus.
摘要:
A mixture of conjugates in which each conjugate in the mixture comprises a calcitonin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may lower serum calcium levels in a subject by 10, 15 or even 20 percent or more. Moreover, the mixture may be more effective at surviving an in vitro model of intestinal digestion than non-conjugated calcitonin. Furthermore, the mixture may exhibit a higher bioavailability than non-conjugated calcitonin. The compositions of this invention are useful in the treatment of various bone disorders and pain.
摘要:
Taxane prodrugs comprise a taxane joined by a hydrolyzable bond to one or more oligomers that comprise a polyethylene glycol moiety. The oligomer preferably further comprises a salt-forming moiety.
摘要:
According to one aspect of an exemplary embodiment of the present disclosure, an aircraft loading/unloading vehicle includes a chassis and a first driving position located at the front of the aircraft loading vehicle. The vehicle also includes a loading platform that is coupled to the chassis. The loading platform is vertically moveable to reach a doorsill height of an aircraft. A cargo cabin is also coupled to the chassis. The cargo cabin encloses a second driving position that allows a driver to face rearward. The second driving position includes a steering controller, a gear selector, and a brake.
摘要:
A diving safety system comprising a floatation buoy acting as a diving line spool, a slip ring within the buoy containing components of a wired and/or wireless electrical communication system allowing an underwater diver to communicate with a boat or shore-based persons, with a method of use.
摘要:
The present invention is broadly directed to systems and methods for gathering information about wireless transceiver devices in a defined boundary region. To this end, the disclosure is more particularly directed to gathering movement information (e.g., via detection and location) about two-way end-user wireless terminals within three-dimensional boundaries of defined local space (“DLS”) to allow for selective control of the terminals and other subsystems, as desired. Additionally, the data collected can be used to improve accuracy and precision regarding the prediction of behavior characteristics and tendencies of populations based on a sampling of observed terminals.