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公开(公告)号：US07381702B2
公开(公告)日：2008-06-03
申请号：US11424295
申请日：2006-06-15
申请人： Nnochiri N. Ekwuribe , Christopher H. Price , James Gordon Still , Jennifer Ann Filbey , Aslam M. Ansari , Amy L. Odenbaugh , Balasingam Radhakrishnan
发明人： Nnochiri N. Ekwuribe , Christopher H. Price , James Gordon Still , Jennifer Ann Filbey , Aslam M. Ansari , Amy L. Odenbaugh , Balasingam Radhakrishnan
CPC分类号： C07K14/62 , A61K38/28 , A61K47/542 , A61K47/60
摘要： Methods of treating diabetes mellitus in a patient in need of such treatment include administering an effective amount of an insulin drug to the patient in order to treat diabetes mellitus in the patient. Methods according to the present invention may “activate” the liver, potentially restoring normal glucose homeostasis to individuals suffering from diabetes mellitus.
摘要翻译： 在需要这种治疗的患者中治疗糖尿病的方法包括向患者施用有效量的胰岛素药物以治疗患者的糖尿病。 根据本发明的方法可以“激活”肝脏，潜在地恢复患有糖尿病的个体的正常葡萄糖体内平衡。
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公开(公告)号：US07423014B2
公开(公告)日：2008-09-09
申请号：US11314309
申请日：2005-12-21
申请人： Nnochiri N. Ekwuribe , Christopher H. Price , James Gordon Still , Jennifer Ann Filbey , Aslam M. Ansari , Amy L. Odenbaugh , Balasingam Radhakrishnan
发明人： Nnochiri N. Ekwuribe , Christopher H. Price , James Gordon Still , Jennifer Ann Filbey , Aslam M. Ansari , Amy L. Odenbaugh , Balasingam Radhakrishnan
CPC分类号： C07K14/62 , A61K38/28 , A61K47/542 , A61K47/60
摘要： Methods of treating diabetes mellitus in a patient in need of such treatment include administering an effective amount of an insulin polypeptide-oligomer conjugate of formula V to the patient in order to treat diabetes mellitus in the patient. Methods according to the present invention may “activate” the liver, potentially restoring normal glucose homeostasis to individuals suffering from diabetes mellitus.
摘要翻译： 在需要这种治疗的患者中治疗糖尿病的方法包括向患者施用有效量的式V的胰岛素多肽 - 低聚物缀合物以便治疗患者的糖尿病。 根据本发明的方法可以“激活”肝脏，潜在地恢复患有糖尿病的个体的正常葡萄糖体内平衡。
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公开(公告)号：US07060675B2
公开(公告)日：2006-06-13
申请号：US10075097
申请日：2002-02-13
CPC分类号： C07K14/62 , A61K38/28 , A61K47/542 , A61K47/60
摘要： Methods of treating diabetes mellitus in a patient in need of such treatment include administering an effective amount of an insulin drug to the patient in order to treat diabetes mellitus in the patient. Methods according to the present invention may “activate” the liver, potentially restoring normal glucose homeostasis to individuals suffering from diabetes mellitus.
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4.发明授权公开(公告)号：US07601688B2
公开(公告)日：2009-10-13
申请号：US10461199
申请日：2003-06-13
摘要： The present invention provides compositions and methods for reducing hypoglycemic episodes experienced by a subject in need of treatment for diabetes mellitus, said method comprising orally administering an amount of an insulin polypeptide-oligomer conjugate to the subject, wherein: i) the amount of the insulin polypeptide-oligomer conjugate reduces the number and/or severity of hypoglycemic episodes experienced by the subject during a given time period when compared with the number and/or severity of hypoglycemic episodes that would have been experienced during a similar time period by the subject or by subjects in a control group parenterally administered insulin or an insulin analog in an amount that provides a substantially equivalent level of glycemic control; and ii) the oligomer of the insulin polypeptide-oligomer conjugate comprises a hydrophilic moiety and a lipophilic moiety.
摘要翻译： 本发明提供了用于减少需要治疗糖尿病的受试者经历的降血糖发作的组合物和方法，所述方法包括口服给予受试者一定量的胰岛素多肽 - 低聚物缀合物，其中：i）胰岛素的量 多肽 - 低聚物缀合物减少受试者在给定时间段期间经历的降血糖发作的次数和/或严重程度，与在受试者相似的时间段内将经历的降血糖发作的数量和/或严重程度相比较， 对照组中的受试者肠胃外施用胰岛素或胰岛素类似物，其量提供基本相当水平的血糖控制; 和ii）胰岛素多肽 - 低聚物缀合物的寡聚物包含亲水部分和亲脂部分。
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