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34 条记录 (耗时 0.041 秒)

    Calcitonin drug-oligomer conjugates, and uses thereof
    7.
    发明授权
    Calcitonin drug-oligomer conjugates, and uses thereof 有权
    降钙素药物 - 低聚物共轭物及其用途

    公开(公告)号：US07713932B2

    公开(公告)日：2010-05-11

    申请号：US10166355

    申请日：2002-11-08

    申请人： Nnochiri N. Ekwuribe ,  Balasingam Radhakrishnan

    发明人： Nnochiri N. Ekwuribe ,  Balasingam Radhakrishnan

    IPC分类号： A61K38/17

    CPC分类号： C07K14/585 ,  A61K47/60

    摘要： Calcitonin drug-oligomer conjugates that include a calcitonin drug coupled to an oligomer including a single polyalkylene glycol moiety consisting of between 4 and 10 polyalkylene glycol subunits are disclosed. Pharmaceutical compositions including such conjugates and methods of treating bone disorders by administering such conjugates are also disclosed.

    摘要翻译： 公开了降钙素药物 - 低聚物缀合物，其包括与包含由4至10个聚亚烷基二醇亚单元组成的单一聚亚烷基二醇部分的低聚物偶联的降钙素药物。 还公开了包含这种缀合物的药物组合物和通过施用这种缀合物治疗骨疾病的方法。

    CALCITONIN DRUG-OLIGOMER CONJUGATES, AND USES THEREOF
    8.
    发明申请
    CALCITONIN DRUG-OLIGOMER CONJUGATES, AND USES THEREOF 有权
    CALCITONIN DRUG-OLIGOMER CONJUGATES及其用途

    公开(公告)号：US20100105624A1

    公开(公告)日：2010-04-29

    申请号：US12606455

    申请日：2009-10-27

    申请人： Nnochiri N. Ekwuribe ,  Balasingam Radhakrishnan

    发明人： Nnochiri N. Ekwuribe ,  Balasingam Radhakrishnan

    IPC分类号： A61K38/23 ,  C07K14/585 ,  A61P19/08

    CPC分类号： C07K14/585 ,  A61K47/60

    摘要： Calcitonin drug-oligomer conjugates that include a calcitonin drug coupled to an oligomer including a single polyalkylene glycol moiety consisting of between 4 and 10 polyalkylene glycol subunits are disclosed. Pharmaceutical compositions including such conjugates and methods of treating bone disorders by administering such conjugates are also disclosed.

    摘要翻译： 公开了降钙素药物 - 低聚物缀合物，其包括与包含由4至10个聚亚烷基二醇亚单元组成的单一聚亚烷基二醇部分的低聚物偶联的降钙素药物。 还公开了包含这种缀合物的药物组合物和通过施用这种缀合物治疗骨疾病的方法。

    Natriuretic compounds, conjugates, and uses thereof
    10.
    发明授权
    Natriuretic compounds, conjugates, and uses thereof 失效
    利尿钠化合物，缀合物及其用途

    公开(公告)号：US07662773B2

    公开(公告)日：2010-02-16

    申请号：US10723933

    申请日：2003-11-26

    申请人： Kenneth D. James ,  Balasingam Radhakrishnan ,  Navdeep B. Malkar ,  Mark A. Miller ,  Nnochiri N. Ekwuribe

    发明人： Kenneth D. James ,  Balasingam Radhakrishnan ,  Navdeep B. Malkar ,  Mark A. Miller ,  Nnochiri N. Ekwuribe

    IPC分类号： A61K38/03 ,  A61K8/64

    CPC分类号： C08G65/329 ,  A61K47/60 ,  C07K14/58 ,  C07K14/72 ,  C08L2203/02

    摘要： Modified natriuretic compounds and conjugates thereof are disclosed in the present invention. In particular, conjugated forms of hBNP are provided that include at least one modifying moiety attached thereto. The modified natriuretic compound conjugates retain activity for stimulating cGMP production, binding to NPR-A receptor, and in some embodiments an improved half-life in circulation as compared to unmodified counterpart natriuretic compounds. Oral, parenteral, subcutaneous, and intravenous forms of the compounds and conjugates may be prepared as treatments and/or therapies for heart conditions particularly congestive heart failure. Modifying moieties comprising oligomeric structures having a variety of lengths and configurations are also disclosed. Analogs of the natriuretic compound are also disclosed, having an amino acid sequence that is other than the native sequence.

    摘要翻译： 本发明公开了改良的利尿钠化合物及其缀合物。 特别地，提供了缀合形式的hBNP，其包括与其连接的至少一个修饰部分。 修饰的利钠化合物缀合物保留用于刺激cGMP产生，与NPR-A受体结合的活性，并且在一些实施方案中，与未修饰的对应利钠化合物相比，循环中的半衰期改善。 可以将口服，胃肠外，皮下和静脉内形式的化合物和缀合物制备为用于心脏状况的治疗和/或治疗，特别是充血性心力衰竭。 还公开了包含具有各种长度和构型的寡聚结构的修饰部分。 还公开了利尿钠化合物的类似物，其具有不同于天然序列的氨基酸序列。