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    PROPHYLACTIC OR THERAPEUTIC AGENT FOR PULMONARY FIBROSIS
    1.
    发明申请
    PROPHYLACTIC OR THERAPEUTIC AGENT FOR PULMONARY FIBROSIS 审中-公开
    预防或治疗慢性阻塞性肺疾病

    公开(公告)号：US20120059020A1

    公开(公告)日：2012-03-08

    申请号：US13319960

    申请日：2009-05-29

    申请人： Noboru Hattori ,  Kentaro Ueda ,  Makoto Akashima ,  Masamichi Takagi

    发明人： Noboru Hattori ,  Kentaro Ueda ,  Makoto Akashima ,  Masamichi Takagi

    IPC分类号： A61K31/505 ,  A61P11/00 ,  C07D239/34

    CPC分类号： A61K31/505 ,  C07D239/34

    摘要： Disclosed is a compound which has an inhibitory activity on plasminogen activator inhibitor-1 (PAI-1) and has a propanedioic acid structure represented by formula (1) [wherein R1 and R2 independently represent a hydrogen atom or a linear or branched alkyl group having 1 to 4 carbon atoms; R3 represents a cyclohexyl group or a phenyl group (provide that the phenyl group may be substituted by a substituent selected from a linear or branched alkyl group having 1 to 4 carbon atoms, a linear or branched alkoxy group having 1 to 4 carbon atoms, and a halogen atom); R4 represents a linear or branched alkyl group having 1 to 6 carbon atoms or a phenyl group (provide that the phenyl group may be substituted by a substituent selected from a linear or branched alkyl group having 1 to 4 carbon atoms, a linear or branched alkoxy group having 1 to 4 carbon atoms, and a halogen atom); and n represents an integer of 1 to 8]. The compound is useful as a prophylactic or therapeutic agent for pulmonary fibrosis.

    摘要翻译： 公开了具有对纤溶酶原激活物抑制剂-1（PAI-1）具有抑制活性并具有由式（1）表示的丙二酸结构的化合物[其中R1和R2独立地表示氢原子或具有 1至4个碳原子; R3表示环己基或苯基（提供苯基可以被选自具有1至4个碳原子的直链或支链烷基的取代基，具有1至4个碳原子的直链或支链烷氧基取代，以及 卤素原子）; R4表示具有1〜6个碳原子的直链或支链烷基或苯基（提供苯基可以被选自具有1至4个碳原子的直链或支链烷基的取代基取代，直链或支链烷氧基 具有1至4个碳原子的基团和卤素原子）; n表示1〜8的整数]。 该化合物可用作肺纤维化的预防或治疗剂。

    Hydroxamic acid derivative and medicine containing the same as active ingredient
    3.
    发明授权
    Hydroxamic acid derivative and medicine containing the same as active ingredient 失效
    羟肟酸衍生物和含有与活性成分相同的药物

    公开(公告)号：US07521563B2

    公开(公告)日：2009-04-21

    申请号：US11659810

    申请日：2004-08-10

    申请人： Kiyoshi Nakatogawa ,  Masamichi Takagi ,  Makoto Akashima

    发明人： Kiyoshi Nakatogawa ,  Masamichi Takagi ,  Makoto Akashima

    IPC分类号： C07D263/30 ,  C07D413/00 ,  C07D277/20 ,  A61K31/42 ,  A61K31/425

    CPC分类号： C07D277/30 ,  C07D263/32 ,  C07D277/22

    摘要： A compound which inhibits the production of IL-6 and/or TNFα by inflammatory cytokines and is useful in the prevention of or treatments for diseases such as various inflammatory diseases in which these cytokines participate and autoimmune diseases. It is a hydroxamic acid derivative represented by the following formula (1): (1) (wherein A and B each represents phenyl, etc.; n is an integer of 1 to 8; and Y represents oxygen or sulfur). This compound has excellent interleukin-6 and/or TNFα production inhibitory activity and is useful as a therapeutic agent for various inflammatory diseases, autoimmune diseases, etc.

    摘要翻译： 抑制炎性细胞因子产生IL-6和/或TNFα的化合物，可用于预防或治疗诸如这些细胞因子参与的各种炎性疾病和自身免疫性疾病等疾病。 由下式（1）表示的异羟肟酸衍生物：（1）（其中A和B各自表示苯基等; n为1〜8的整数，Y为氧或硫）。 该化合物具有优异的白细胞介素-6和/或TNFα产生抑制活性，可用作各种炎性疾病，自身免疫性疾病等的治疗剂。

    Hydroxamic Acid Derivative and Medicine Containing the Same as Active Ingredient
    4.
    发明申请
    Hydroxamic Acid Derivative and Medicine Containing the Same as Active Ingredient 失效
    羟肟酸衍生物和含有与活性成分相同的药物

    公开(公告)号：US20070208065A1

    公开(公告)日：2007-09-06

    申请号：US11659810

    申请日：2004-08-10

    申请人： Kiyoshi Nakatogawa ,  Masamichi Takagi ,  Makoto Akashima

    发明人： Kiyoshi Nakatogawa ,  Masamichi Takagi ,  Makoto Akashima

    IPC分类号： A61K31/426 ,  A61K31/421 ,  C07D277/30 ,  C07D263/34

    CPC分类号： C07D277/30 ,  C07D263/32 ,  C07D277/22

    摘要： A compound which inhibits the production of IL-6 and/or TNFα by inflammatory cytokines and is useful in the prevention of or treatments for diseases such as various inflammatory diseases in which these cytokines participate and autoimmune diseases. It is a hydroxamic acid derivative represented by the following formula (1): (1) (wherein A and B each represents phenyl, etc.; n is an integer of 1 to 8; and Y represents oxygen or sulfur). This compound has excellent interleukin-6 and/or TNFα production inhibitory activity and is useful as a therapeutic agent for various inflammatory diseases, autoimmune diseases, etc.

    摘要翻译： 抑制炎性细胞因子产生IL-6和/或TNFα的化合物，可用于预防或治疗诸如这些细胞因子参与的各种炎性疾病和自身免疫性疾病等疾病。 由下式（1）表示的异羟肟酸衍生物：（1）（其中A和B各自表示苯基等; n为1〜8的整数，Y为氧或硫）。 该化合物具有优异的白细胞介素-6和/或TNFα产生抑制活性，可用作各种炎性疾病，自身免疫性疾病等的治疗剂。