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公开(公告)号：US20080193516A1
公开(公告)日：2008-08-14
申请号：US12031376
申请日：2008-02-14
申请人： Nobuaki HORI , Yoshihisa Manabe , Yuko Suka , Toshiya Kai , Seiji Nishida , Naohisa Katayama
发明人： Nobuaki HORI , Yoshihisa Manabe , Yuko Suka , Toshiya Kai , Seiji Nishida , Naohisa Katayama
IPC分类号： A61K9/127 , A61K38/41 , A61P7/00 , A61K31/555
CPC分类号： A61K47/183 , A61K9/1271 , A61K9/1272 , A61K38/41 , A61K38/42 , A61K47/12 , A61K47/24
摘要： An oxygen-carrying blood substitute preparation stable upon storage is provided. The preparation comprises an oxygen-carrying substance capable of reversibly binding and releasing oxygen in vivo and an amount of a physiologically tolerable reducing agent effective for preventing at least partially irreversible oxidation of said oxygen-carrying substance. Preferably the oxygen-carrying substance is a hemoglobin-based substance in the form of a liposome encapsulating hemoglobin.
摘要翻译： 提供了一种在储存时稳定的载氧血液替代物制剂。 该制剂包含能够在体内可逆地结合和释放氧的携氧物质以及有效预防所述携氧物质的至少部分不可逆氧化的生理上可耐受的还原剂的量。 优选地，携氧物质是包封血红蛋白的脂质体形式的基于血红蛋白的物质。
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公开(公告)号：US20100145298A1
公开(公告)日：2010-06-10
申请号：US12704700
申请日：2010-02-12
申请人： Nobuaki HORI , Yoshihisa Manabe , Yuko Suka , Toshiya Kai , Seiji Nishida , Naohisa Katayama
发明人： Nobuaki HORI , Yoshihisa Manabe , Yuko Suka , Toshiya Kai , Seiji Nishida , Naohisa Katayama
IPC分类号： A61J1/10
CPC分类号： A61K47/183 , A61K9/1271 , A61K9/1272 , A61K38/41 , A61K38/42 , A61K47/12 , A61K47/24
摘要： An oxygen-carrying blood substitute preparation stable upon storage is provided. The preparation comprises an oxygen-carrying substance capable of reversibly binding and releasing oxygen in vivo and an amount of a physiologically tolerable reducing agent effective for preventing at least partially irreversible oxidation of said oxygen-carrying substance. Preferably the oxygen-carrying substance is a hemoglobin-based substance in the form of a liposome encapsulating hemoglobin.
摘要翻译： 提供了一种在储存时稳定的载氧血液替代物制剂。 该制剂包含能够在体内可逆地结合和释放氧的携氧物质以及有效预防所述携氧物质的至少部分不可逆氧化的生理上可耐受的还原剂的量。 优选地，携氧物质是包封血红蛋白的脂质体形式的基于血红蛋白的物质。
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