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公开(公告)号:US5770767A
公开(公告)日:1998-06-23
申请号:US593940
申请日:1996-01-30
申请人: Nobushige Itaya , Ryuhei Wakita , Asako Kubo , Mikio Sasaki , Takashi Namba , Yusuke Yukimoto
发明人: Nobushige Itaya , Ryuhei Wakita , Asako Kubo , Mikio Sasaki , Takashi Namba , Yusuke Yukimoto
IPC分类号: C07C51/377 , C07C61/15 , C07C61/04
CPC分类号: C07C61/15 , C07C51/377
摘要: A process for producing a 2-fluorocyclopropane-carboxylic acid of formula �I! ##STR1## by reducing a 2-halo-2-fluorocyclopropanecarboxylic acid of formula �II! ##STR2## the reduction being carried out by developing a Raney nickel alloy in the presence of the 2-halo-2-fluorocyclo-propanecarboxylic acid of formula �II!, or by contacting the 2-halo-2-fluorocyclopropanecarboxylic acid of formula �II! with hydrogen in an aqueous solvent using a Raney nickel catalyst.
摘要翻译: 通过还原式[II]的2-卤代-2-氟环丙烷羧酸[II],制备式[I]的2-氟环丙烷 - 羧酸的方法通过将式[II]的2-卤代-2-氟环丙烷羧酸还原为 在式[II]的2-卤代-2-氟代环丙烷羧酸存在下研磨阮内镍合金,或者通过使式[Ⅱ]的2-卤代-2-氟环丙烷羧酸与氢在水溶剂中接触,使用 阮内镍催化剂。
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公开(公告)号:US20070276011A1
公开(公告)日:2007-11-29
申请号:US10571324
申请日:2004-09-03
申请人: Susumu Muto , Asako Kubo , Akiko Itai , Tomomi Sotome , Yoichi Yamaguchi
发明人: Susumu Muto , Asako Kubo , Akiko Itai , Tomomi Sotome , Yoichi Yamaguchi
IPC分类号: A61K31/426 , A61K31/4152 , A61K31/44 , A61P7/02 , C07D231/18 , C07D277/34 , C07D417/06 , C07D233/70 , A61P7/04 , A61P7/00 , A61K31/4166
CPC分类号: C07D405/06 , C07D231/20 , C07D277/20 , C07D279/06 , C07D409/06 , C07D417/06 , C07D417/12
摘要: A medicament having inhibitory activity against plasminogen activator inhibitor-1, which comprises as an active ingredient a compound represented by the following general formula (I) or a salt thereof: wherein R1 and R2 represents an aromatic group which may be substituted, W represents a group selected from the following connecting group W-1: (wherein a bond at the left end binds to the carbon atom and a bond at the right end binds to the nitrogen atom, X represents sulfur atom or NH, Y represents oxygen atom or sulfur atom, R3 represents a hydrocarbon group, hydroxy group, or carboxy group), Z represents a single bond or a connecting group wherein a number of atoms in a main chain is 1 to 3.
摘要翻译: 一种对纤溶酶原激活物抑制剂-1具有抑制活性的药物,其包含作为活性成分的由以下通式(I)表示的化合物或其盐:其中R 1和R 2 表示可以被取代的芳基,W表示选自以下连接基团W-1中的基团:(其中左端的键与碳原子结合,右端的键与 氮原子,X表示硫原子或NH,Y表示氧原子或硫原子,R 3表示烃基,羟基或羧基),Z表示单键或连接基团,其中 主链中的原子数为1〜3。
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