公开(公告)号：US5187195A

公开(公告)日：1993-02-16

申请号：US543437

申请日：1990-06-26

申请人： Nobutaka Oohata ,  Motoaki Nishikawa ,  Sumio Kiyoto ,  Shigehiro Takase ,  Keiji Hemmi ,  Hidetsugu Murai ,  Masakuni Okuhara

发明人： Nobutaka Oohata ,  Motoaki Nishikawa ,  Sumio Kiyoto ,  Shigehiro Takase ,  Keiji Hemmi ,  Hidetsugu Murai ,  Masakuni Okuhara

IPC分类号： C12P13/02 ,  A61K31/16 ,  A61K31/195 ,  A61K31/215 ,  A61K38/00 ,  A61P9/00 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  C07C323/25 ,  C07C323/41 ,  C07C323/59 ,  C07C323/60 ,  C07D209/20 ,  C07K5/06 ,  C07K5/083 ,  C12N1/20 ,  C12P13/00 ,  C12R1/38 ,  C12R1/465

CPC分类号： C12P13/001 ,  C07C323/59 ,  C07C323/60 ,  C07K5/0606 ,  C07K5/081 ,  A61K38/00 ,  C07C2103/42 ,  Y10S514/929

摘要： Anthraquinone compounds of the formula: ##STR1## wherein: R.sup.1 is hydrogen, hydroxy or acyloxy,R.sup.2 is hydrogen or acyl,R.sup.3 is acyl,R.sup.4 is hydrogen or acyl,R.sup.5 is hydrogen or acyl,R.sup.6 is hydrogen or acyl, andR.sup.7 is hydrogen or acylhave been found to possess endothelin antagonistic properties and are producible by various synthetic and fermentation processes.

公开(公告)号：US5061730A

公开(公告)日：1991-10-29

申请号：US143942

申请日：1988-01-14

申请人： Itsuo Uchida ,  Hiroshi Hatanaka ,  Kumiko Nitta ,  Seiji Hashimoto ,  Masakuni Okuhara ,  Hidetsugu Murai ,  Masashi Hashimoto

发明人： Itsuo Uchida ,  Hiroshi Hatanaka ,  Kumiko Nitta ,  Seiji Hashimoto ,  Masakuni Okuhara ,  Hidetsugu Murai ,  Masashi Hashimoto

IPC分类号： C07D211/94 ,  A01N37/36 ,  A61K31/19 ,  A61P43/00 ,  C07C67/00 ,  C07C239/00 ,  C07C259/06 ,  C12N9/99 ,  C12P13/00 ,  C12R1/465

CPC分类号： A61K31/19

摘要： This invention relates to new carboxylic acid derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen, lower alkyl or aryl, and pharmaceutically acceptable salt thereof which inhibit activity of DHP-I, to a process for preparing them and to an antibacterial composition comprising them and carbapenem antibiotics.

公开(公告)号：US4670259A

公开(公告)日：1987-06-02

申请号：US813065

申请日：1985-12-24

申请人： Sumio Kiyoto ,  Hidetsugu Murai ,  Yasuhisa Tsurumi ,  Hiroshi Terano ,  Masanobu Kohsaka

发明人： Sumio Kiyoto ,  Hidetsugu Murai ,  Yasuhisa Tsurumi ,  Hiroshi Terano ,  Masanobu Kohsaka

IPC分类号： C12N1/16 ,  A61K36/06 ,  A61K36/07 ,  A61P35/00 ,  C07G11/00 ,  C12N1/14 ,  C12P1/02 ,  C12R1/645 ,  A61K35/70 ,  A61K35/72

CPC分类号： C12P1/02

摘要： The invention relates to a new compound, designated FR-68504. The compound has antitimor activities and is effective in the treatment of various tumors in both human beings and animals.There is also provided a process for preparing FR-68504 compound which comprises culturing a FR-68504 producing strain belonging to the genus Amauroascus in a nutrient medium.Pharmaceutical composition comprising FR-68504 as an active ingredient is also described.

摘要翻译： 本发明涉及一种名为FR-68504的新化合物。 该化合物具有抗肿瘤活性，在人和动物的各种肿瘤治疗中均有效。 还提供了制备FR-68504化合物的方法，该方法包括在营养培养基中培养属于阿莫罗氏菌属的FR-68504生产菌株。 还描述了包含FR-68504作为活性成分的药物组合物。