公开(公告)号：US20240336940A1

公开(公告)日：2024-10-10

申请号：US18628394

申请日：2024-04-05

申请人： MYCOCYCLE, INC.

发明人： Joanne Rodriguez

IPC分类号： C12P1/02 ,  C12M1/00 ,  C12M3/00 ,  C12N1/14

CPC分类号： C12P1/02 ,  C12M23/44 ,  C12M23/52 ,  C12N1/14

摘要： Disclosed and claimed are systems and methods for on-site bioremediation of scrap material using a self-contained receptacle.

公开(公告)号：US20240254517A1

公开(公告)日：2024-08-01

申请号：US18289441

申请日：2022-04-26

申请人： ACT LLC ,  Sumihisa FUJIWARA

发明人： Seita UI

IPC分类号： C12P1/02 ,  C12N1/14

CPC分类号： C12P1/02 ,  C12N1/14

摘要： An object is to develop a novel fermentation technique by use of fermentation by an ascomycetous white wood-rotting fungus having mycorrhizal characteristics. A physiologically active substance-containing fermented product is manufactured by use of the production of a physiologically active substance by the fermentation of a raw material by an ascomycetous white wood-rotting fungus having mycorrhizal characteristics. Residual agricultural chemicals in a food raw material are degraded by use of the degradation of a persistent compound. A contained component is extracted at a high speed by use of the weakening of a plant cell membrane.

公开(公告)号：US20240229047A1

公开(公告)日：2024-07-11

申请号：US18406738

申请日：2024-01-08

申请人： Mojia Biotech Pte. Ltd.

发明人： Ramon Gonzalez ,  James MacAllister Clomburg ,  Fayin Zhu ,  Seung Hwan Lee ,  Mohammadreza Nezamirad

IPC分类号： C12N15/52 ,  C12N9/00 ,  C12N9/02 ,  C12N9/04 ,  C12N9/10 ,  C12N9/12 ,  C12N9/16 ,  C12N9/88 ,  C12P1/02 ,  C12P1/04

CPC分类号： C12N15/52 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/0093 ,  C12N9/1029 ,  C12N9/1217 ,  C12N9/16 ,  C12N9/88 ,  C12N9/93 ,  C12P1/02 ,  C12P1/04 ,  C12Y101/01001 ,  C12Y102/01003 ,  C12Y207/02006 ,  C12Y301/0202 ,  C12Y402/01028

摘要： This disclosure provides a new conceptual framework in which orthogonal, new-to-nature carbon and energy conversion pathways facilitate the synthesis of fuels and chemicals from carboxylic acid intermediates (CAis) driven by genetically altered microorganisms. This allows the CAi platform to generate diverse products at ≥100% carbon yield while retaining the established high product and energy efficiencies of fermentative metabolism. In another embodiment, a carboxylic acid platform for fuel and chemical production at high carbon and energy efficiency is also provided.

公开(公告)号：US12031170B2

公开(公告)日：2024-07-09

申请号：US17744300

申请日：2022-05-13

申请人： DANMARKS TEKNISKE UNIVERSITET

发明人： Peter Rugbjerg ,  Kira Sarup-Lytzen ,  Morten Sommer

IPC分类号： C12P7/42 ,  C12N1/21 ,  C12N9/16 ,  C12N15/10 ,  C12N15/67 ,  C12N15/72 ,  C12P1/02 ,  C12P1/04 ,  C12P5/02 ,  C12P7/40 ,  C12P7/64 ,  C12P21/02

CPC分类号： C12P7/42 ,  C12N9/16 ,  C12N15/1086 ,  C12N15/67 ,  C12N15/72 ,  C12P1/02 ,  C12P1/04 ,  C12P5/026 ,  C12P7/40 ,  C12P7/64 ,  C12P21/02

摘要： The invention provides a genetically modified micro-organism for intracellular biosynthesis of a cellular metabolite, comprising a synthetic error correction system having a penalty gene, whose expression leads to arrested growth or cell death (e.g. a toxin gene) in combination with a survival gene, whose expression provides an antidote that restores cell viability and normal growth (e.g. a cognate antitoxin gene). Alternatively, the system has a survival gene, alone, whose expression is essential for growth (i.e. essential gene). The synthetic error correction system further comprises a biosensor, whose function is to induce expression of the survival gene which leads to cell growth, only, when the cell produces a pre-defined level of a given metabolite. The invention further encompasses: a method for producing the genetically modified micro-organism; a method for producing a cellular metabolite with the genetically modified micro-organism; and use of the genetically modified micro-organism for producing a cellular metabolite.

公开(公告)号：US20240182846A1

公开(公告)日：2024-06-06

申请号：US18524456

申请日：2023-11-30

申请人： MYCOCYCLE, INC.

发明人： Joanne Rodriguez

IPC分类号： C12N1/14 ,  C12P1/02

CPC分类号： C12N1/14 ,  C12P1/02 ,  C12R2001/645

摘要： Disclosed are methods for reducing contaminant levels in materials through remediation, including remediation using a filamentous fungus.

公开(公告)号：US20240117385A1

公开(公告)日：2024-04-11

申请号：US18244763

申请日：2023-09-11

申请人： LIGHT BIO, INC.

发明人： Il'ya Viktorovich YAMPOL'SKIY

IPC分类号： C12P1/02 ,  C07K14/37

CPC分类号： C12P1/02 ,  C07K14/37 ,  C12Y113/12007

摘要： Present invention is aimed at identification of new fungal luciferin biosynthesis enzymes, nucleic acids able to encode these enzymes, and proteins able to catalyze certain stages of the fungal luciferin biosynthesis. The invention also provides for application of nucleic acids for producing said enzymes in a cell or organism. Methods for in vitro or in vivo preparation of chemical compounds identical to fungal luciferins and preluciferins are also provided. Vectors comprising nucleic acid described in the present invention are also provided. In addition, the present invention provides expression cassettes comprising the nucleic acid of the present invention and regulatory elements necessary for nucleic acid expression in a selected host cell. Besides, cells, stable cell lines, transgenic organisms (e.g. plants, animals, fungi, or microorganisms) including nucleic acids, vectors, or expression cassettes of the present invention are also provided. Present invention also provides combinations of nucleic acids to obtain autonomously luminous cells, cell lines, or transgenic organisms. In preferred embodiments, cells or transgenic organisms are capable to produce fungal luciferin from precursors. In some embodiments, cells or transgenic organisms are capable to produce fungal preluciferin from precursors. In some embodiments, cells or transgenic organisms are capable of bioluminescence in the presence of a fungal luciferin precursor. In some embodiments, cells or transgenic organisms are capable of autonomous bioluminescence. Combinations of proteins for producing luciferin or its precursors from more simple chemical compounds are also provided. A kit containing nucleic acids, vectors, or expression cassettes of the present invention for producing luminous cells, cell lines, or transgenic organisms is also provided.

公开(公告)号：US20180021398A1

公开(公告)日：2018-01-25

申请号：US15213806

申请日：2016-07-19

申请人： Sagittarius Life Science Corp.

发明人： Ming-Chi Shih

IPC分类号： A61K36/899 ,  C12P1/02 ,  A23L33/105 ,  A61K45/06

CPC分类号： A61K36/899 ,  A23L33/105 ,  A23V2002/00 ,  A61K45/06 ,  A61K2236/19 ,  A61K2236/333 ,  C12P1/02

摘要： The invention provides a fermented Pennisetum extract, which has an advantageous effect in treating and preventing a cancer without toxicity to normal cells. The invention also provides a process of preparing the fermented Pennisetum extract and the application of the fermented Pennisetum extract in the treatment or prevention of a cancer.

公开(公告)号：US09873881B2

公开(公告)日：2018-01-23

申请号：US15498011

申请日：2017-04-26

申请人： Novozymes, Inc.

发明人： Debbie Yaver ,  Peter Nham

IPC分类号： C12N15/80 ,  C12N9/06 ,  C12N9/00 ,  C12N9/58 ,  C12N9/20

CPC分类号： C12N15/80 ,  C12N9/0044 ,  C12N9/20 ,  C12N9/58 ,  C12N9/93 ,  C12N15/113 ,  C12P1/02 ,  C12P21/00 ,  C12Y107/01003 ,  C12Y301/01003 ,  C12Y304/21004 ,  C12Y603/04002

摘要： The present invention relates to methods for producing a biological substance, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the biological substance, wherein the fungal host cell comprises a first nucleic acid sequence encoding the biological substance operably linked to a second nucleic acid sequence comprising a promoter variant selected from the group consisting of SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, and SEQ ID NO: 12; and a subsequence thereof; and hybrid and tandem promoters thereof; and (b) isolating the biological substance from the cultivation medium. The present invention also relates to the isolated promoter variants and to constructs, vectors, and fungal host cells comprising the promoter variants operably linked to nucleic acid sequences encoding biological substances.

公开(公告)号：US09770037B2

公开(公告)日：2017-09-26

申请号：US14838143

申请日：2015-08-27

申请人： Donaghys Limited

发明人： Timothy Allen Jenkins

IPC分类号： A01N63/00 ,  A01N63/02 ,  A01N63/04 ,  C05C9/00 ,  C12N1/18 ,  C12N1/20 ,  C12P1/02 ,  C12P1/04 ,  C05G3/00

CPC分类号： A01N63/02 ,  A01N63/04 ,  C05C9/00 ,  C05G3/00 ,  C12N1/18 ,  C12N1/20 ,  C12P1/02 ,  C12P1/04 ,  A01N47/28 ,  C05F11/08 ,  A01N2300/00

摘要： A bio-stimulant composition for obtaining improved plant growth, either combined or uncombined with urea and/or other agricultural compounds, as well of methods of producing and using said composition.

公开(公告)号：US09682116B2

公开(公告)日：2017-06-20

申请号：US14614113

申请日：2015-02-04

申请人： United Arab Emirates University

发明人： Ahmed Soliman Hussein ,  Ibrahim Hassan Belal ,  Salem Rashed Ali Alyalyali ,  Khaled Abas El Tarabily

IPC分类号： C12P1/04 ,  A61K36/889 ,  C12P1/02 ,  A23K10/12 ,  A23K10/37 ,  A23K20/163 ,  A23K20/195 ,  A23K50/20 ,  A23K50/10 ,  A23K50/75 ,  A23K50/30 ,  A23K50/80 ,  A23K10/26 ,  A23K10/30 ,  A23K20/174 ,  A23K20/142 ,  A23K20/158 ,  A23K20/20

CPC分类号： A61K36/889 ,  A23K10/12 ,  A23K10/26 ,  A23K10/30 ,  A23K10/37 ,  A23K20/142 ,  A23K20/158 ,  A23K20/163 ,  A23K20/174 ,  A23K20/195 ,  A23K20/30 ,  A23K50/10 ,  A23K50/20 ,  A23K50/30 ,  A23K50/75 ,  A23K50/80 ,  A61K9/14 ,  A61K31/7004 ,  A61K31/702 ,  A61K2236/19 ,  C12P1/02 ,  Y02A40/818 ,  Y02P60/877

摘要： A method of treating or preventing bacterial infection in an animal comprises administering an effective amount of degraded date pits. Degraded date pits can be produced by the treatment of date pits with fungi.