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    2-methylpropionic acid derivatives and pharmaceutical compositions comprising the same
    9.
    发明授权
    2-methylpropionic acid derivatives and pharmaceutical compositions comprising the same 失效
    2-甲基丙酸衍生物和包含它们的药物组合物

    公开(公告)号：US06790865B2

    公开(公告)日：2004-09-14

    申请号：US10358214

    申请日：2003-02-05

    申请人： Tetsuro Tamai ,  Nobuyuki Tanaka ,  Harunobu Mukaiyama ,  Akihito Hirabayashi ,  Hideyuki Muranaka ,  Masaaki Sato ,  Masuo Akahane

    发明人： Tetsuro Tamai ,  Nobuyuki Tanaka ,  Harunobu Mukaiyama ,  Akihito Hirabayashi ,  Hideyuki Muranaka ,  Masaaki Sato ,  Masuo Akahane

    IPC分类号： A61K3124

    CPC分类号： C07C217/60 ,  C07C229/18

    摘要： The present invention provides novel 2-methylpropionic acid derivatives represented by the general formula: (wherein R1 represents a hydrogen atom, a lower alkyl group or an aralkyl group; R2 represents a hydrogen atom, a lower alkyl group or a halogen atom; A represents an oxygen atom or an imino group; the carbon atom marked with (R) represents a carbon atom in R configuration; and the carbon atom marked with (S) represents a carbon atom in S configuration) and pharmaceutically acceptable salts thereof, which have excellent &bgr;3-adrenoceptor stimulating effects and are useful as agents for the prevention or treatment of obesity, hyperglycemia, the diseases caused by intestinal hypermotility, pollakiuria, urinary incontinence, depression, or the diseases caused by biliary calculi or hypermotility of the biliary tract.

    摘要翻译： 本发明提供由以下通式表示的新型2-甲基丙酸衍生物：其中R 1表示氢原子，低级烷基或芳烷基; R 2表示氢原子，低级烷基或 卤素原子; A表示氧原子或亚氨基;由（R）表示的碳原子表示R构型的碳原子，标有（S）的碳原子表示S构型的碳原子）和药学上可接受的 其具有优异的β3肾上腺素能受体刺激作用，并且可用作预防或治疗肥胖症，高血糖症，由肠蠕动过多引起的疾病，尿频尿症，尿失禁，抑郁症或由胆汁结石或运动障碍引起的疾病 胆道。