公开(公告)号：US06790865B2

公开(公告)日：2004-09-14

申请号：US10358214

申请日：2003-02-05

申请人： Tetsuro Tamai ,  Nobuyuki Tanaka ,  Harunobu Mukaiyama ,  Akihito Hirabayashi ,  Hideyuki Muranaka ,  Masaaki Sato ,  Masuo Akahane

发明人： Tetsuro Tamai ,  Nobuyuki Tanaka ,  Harunobu Mukaiyama ,  Akihito Hirabayashi ,  Hideyuki Muranaka ,  Masaaki Sato ,  Masuo Akahane

IPC分类号： A61K3124

CPC分类号： C07C217/60 ,  C07C229/18

摘要： The present invention provides novel 2-methylpropionic acid derivatives represented by the general formula: (wherein R1 represents a hydrogen atom, a lower alkyl group or an aralkyl group; R2 represents a hydrogen atom, a lower alkyl group or a halogen atom; A represents an oxygen atom or an imino group; the carbon atom marked with (R) represents a carbon atom in R configuration; and the carbon atom marked with (S) represents a carbon atom in S configuration) and pharmaceutically acceptable salts thereof, which have excellent &bgr;3-adrenoceptor stimulating effects and are useful as agents for the prevention or treatment of obesity, hyperglycemia, the diseases caused by intestinal hypermotility, pollakiuria, urinary incontinence, depression, or the diseases caused by biliary calculi or hypermotility of the biliary tract.

摘要翻译： 本发明提供由以下通式表示的新型2-甲基丙酸衍生物：其中R 1表示氢原子，低级烷基或芳烷基; R 2表示氢原子，低级烷基或 卤素原子; A表示氧原子或亚氨基;由（R）表示的碳原子表示R构型的碳原子，标有（S）的碳原子表示S构型的碳原子）和药学上可接受的 其具有优异的β3肾上腺素能受体刺激作用，并且可用作预防或治疗肥胖症，高血糖症，由肠蠕动过多引起的疾病，尿频尿症，尿失禁，抑郁症或由胆汁结石或运动障碍引起的疾病 胆道。

公开(公告)号：US06696489B1

公开(公告)日：2004-02-24

申请号：US09673308

申请日：2000-10-13

申请人： Tetsuro Tamai ,  Nobuyuki Tanaka ,  Harunobu Mukaiyama ,  Akihito Hirabayashi ,  Hideyuki Muranaka ,  Masaaki Sato ,  Masuo Akahane

发明人： Tetsuro Tamai ,  Nobuyuki Tanaka ,  Harunobu Mukaiyama ,  Akihito Hirabayashi ,  Hideyuki Muranaka ,  Masaaki Sato ,  Masuo Akahane

IPC分类号： A61K3124

CPC分类号： C07C217/60 ,  C07C229/18

摘要： The present invention provides novel 2-methylpropionic acid derivatives represented by the general formula: (wherein R1 represents a hydrogen atom, a lower alkyl group or an aralkyl group; R2 represents a hydrogen atom a lower alkyl group or a halogen atom; A represents an oxygen atom or an imino group; the carbon atom marked with (R) represents a carbon atom in R configuration; and the carbon atom marked with (S) represents a carbon atom in S configuration) and pharmaceutically acceptable salts thereof, which have excellent &bgr;3-adrenoceptor stimulating effects and are useful as agents for the prevention or treatment of obesity, hyperglycemia, the diseases caused by intestinal hypermotility, pollakiuria, urinary incontinence, depression, or the diseases caused by biliary calculi or hypermotility of the biliary tract.

摘要翻译： 本发明提供由以下通式表示的新型2-甲基丙酸衍生物：其中R 1表示氢原子，低级烷基或芳烷基; R 2表示氢原子，低级烷基或 卤素原子; A表示氧原子或亚氨基;由（R）标记的碳原子表示R构型的碳原子;标有（S）的碳原子表示S构型的碳原子）和药学上可接受的盐 其具有优异的β3肾上腺素能受体刺激作用，并且可用作预防或治疗肥胖症，高血糖症，由肠蠕动过多引起的疾病，尿尿症，尿失禁，抑郁症或由胆汁结石或运动障碍引起的疾病 胆道。

公开(公告)号：US06538152B1

公开(公告)日：2003-03-25

申请号：US09720976

申请日：2001-01-03

申请人： Nobuyuki Tanaka ,  Tetsuro Tamai ,  Harunobu Mukaiyama ,  Akihito Hirabayashi ,  Hideyuki Muranaka ,  Masaaki Sato ,  Masuo Akahane

发明人： Nobuyuki Tanaka ,  Tetsuro Tamai ,  Harunobu Mukaiyama ,  Akihito Hirabayashi ,  Hideyuki Muranaka ,  Masaaki Sato ,  Masuo Akahane

IPC分类号： C07C22900

CPC分类号： C07C217/60 ,  C07C233/43 ,  C07C235/06 ,  C07C235/60 ,  C07C255/59

摘要： The present invention provides novel phenoxyacetic acid derivatives represented by the general formula: wherein R1 represents a hydroxy group, a lower alkoxy group, an aralkoxy group, an amino group, or a mono or di(lower alkyl)amino group; one of R2 and R3 is a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group, while the other is a hydrogen atom; R4 represents a halogen atom, a lower alkyl group, a halo(lower alkyl) group, a hydroxy group, a lower alkoxy group, an aralkoxy group, a cyano group, a nitro group, an amino group, a mono or di(lower alkyl)amino group, a carbamoyl group, a mono or di(lower alkyl)carbamoyl group or a group represented by the general formula: —NHCOR5 (wherein R5 represents a hydrogen atom or a lower alkyl group); the carbon atom marked with (R) represents a carbon atom in R configuration; and the carbon atom marked with (S) represents a carbon atom in S configuration, and pharmaceutically acceptable salts thereof, which have excellent &bgr;3-adrenoceptor stimulating effects and are useful as agents for the prevention or treatment of obesity, hyperglycemia, the diseases caused by intestinal hypermotility, pollakiuria, urinary incontinence, depression, or the diseases caused by biliary calculi or hypermotility of biliary tract.

摘要翻译： 本发明提供由通式表示的新型苯氧基乙酸衍生物：其中R1表示羟基，低级烷氧基，芳烷氧基，氨基或单或二（低级烷基）氨基; R2和R3中的一个是氢原子，卤素原子，低级烷基或低级烷氧基，而另一个是氢原子; R4表示卤原子，低级烷基，卤代（低级烷基），羟基，低级烷氧基，芳烷氧基，氰基，硝基，氨基，单或二（低级） 烷基）氨基，氨基甲酰基，一或二（低级烷基）氨基甲酰基或由通式表示的基团：其中R5表示氢原子或低级烷基; 用（R）标记的碳原子表示R构型的碳原子; 标记有（S）的碳原子表示S构型的碳原子及其药学上可接受的盐，其具有优异的β3肾上腺素能受体刺激作用，并且可用作预防或治疗肥胖，高血糖，由高血糖引起的疾病 肠蠕动过多，尿频尿失禁，抑郁症，胆汁结石或胆汁运动障碍引起的疾病。

公开(公告)号：US06353025B1

公开(公告)日：2002-03-05

申请号：US09581851

申请日：2000-06-19

申请人： Tetsuro Tamai ,  Nobuyuki Tanaka ,  Harunobu Mukaiyama ,  Akihito Hirabayashi ,  Hideyuki Muranaka ,  Masaaki Sato ,  Masuo Akahane

发明人： Tetsuro Tamai ,  Nobuyuki Tanaka ,  Harunobu Mukaiyama ,  Akihito Hirabayashi ,  Hideyuki Muranaka ,  Masaaki Sato ,  Masuo Akahane

IPC分类号： A01N3712

CPC分类号： C07D295/185 ,  C07C229/18 ,  C07C237/06

摘要： The present invention provides novel phenylaminoalkyl-carboxylic acid derivatives represented by the general formula: (wherein R1 represents a hydroxy group, a lower alkoxy group, an aralkoxy group, an amino group, an alicyclic amino group or a mono or di(lower alkyl)amino group which may have a hydroxy group or a lower alkoxy group as a substituent; R2 represents a hydrogen atom or a lower alkyl group; R3 represents a hydrogen atom or a halogen atom; R4 and R5 are the same or different and each represents a hydrogen atom, a halogen atom or a lower alkyl group; A represents a lower alkylene group; the carbon atom marked with (R) represents a carbon atom in (R) configuration; and the carbon atom marked with (S) represents a carbon atom in (S) configuration) and pharmaceutically acceptable salts thereof, which have excellent &bgr;3-adrenoceptor stimulating effects and are useful as agents for the prevention or treatment of obesity, hyperglycemia, the diseases caused by intestinal hypermotility, pollakiuria, urinary incontinence, depression, or the diseases caused by biliary calculi or hypermotility of biliary tract.

摘要翻译： 本发明提供由通式（其中R1表示羟基，低级烷氧基，芳烷氧基，氨基，脂环族氨基或单或二（低级烷基））表示的新型苯基氨基烷基 - 羧酸衍生物， 可以具有羟基或低级烷氧基作为取代基的氨基; R2表示氢原子或低级烷基; R3表示氢原子或卤素原子; R4和R5相同或不同，表示 氢原子，卤素原子或低级烷基; A表示低级亚烷基;（R）表示的碳原子表示（R）构型的碳原子，（S）表示的碳原子表示碳原子 （S）构型）及其药学上可接受的盐，其具有优异的β3肾上腺素能受体刺激作用，并且可用作预防或治疗肥胖症，高血糖症，由肠道超嗜热引起的疾病 遗尿，尿频，尿失禁，抑郁症或由胆汁结石或胆汁运动障碍引起的疾病。

公开(公告)号：US06399660B1

公开(公告)日：2002-06-04

申请号：US09463432

申请日：2000-03-31

申请人： Tetsuro Tamai ,  Nobuyuki Tanaka ,  Hideyuki Muranaka ,  Harunobu Mukaiyama ,  Akihito Hirabayashi ,  Masaaki Sato ,  Masuo Akahane

发明人： Tetsuro Tamai ,  Nobuyuki Tanaka ,  Hideyuki Muranaka ,  Harunobu Mukaiyama ,  Akihito Hirabayashi ,  Masaaki Sato ,  Masuo Akahane

IPC分类号： A01N3712

CPC分类号： C07C217/60

摘要： Novel aminoethylphenoxyacetic acid derivatives represented by the general formula: (wherein R1 represents a hydrogen atom, a lower alkyl group or an aralkyl group; R2 represents a hydrogen atom or a halogen atom; the carbon atom marked with (R) represents a carbon atom in (R) configuration; and the carbon atom marked with (S) represents a carbon atom in (S) configuration) and pharmaceutically acceptable salts thereof, which have stimulating effects on both &bgr;2- and &bgr;3-adrenoceptors and are useful as agents for relieving pain and promoting the removal of calculi in urolithiasis.

摘要翻译： 由以下通式表示的新型氨基乙基苯氧基乙酸衍生物（其中R1表示氢原子，低级烷基或芳烷基; R2表示氢原子或卤素原子;用（R）表示的碳原子表示碳原子 （S）构型的标记的碳原子和（S）标记的碳原子表示（S）构型的碳原子）及其药学上可接受的盐，其对β2-和β3-肾上腺素受体具有刺激作用，并且可用作缓解疼痛的药剂 并促进排尿结石的结石。

公开(公告)号：US08868174B2

公开(公告)日：2014-10-21

申请号：US13202784

申请日：2010-02-22

申请人： Masaaki Sato ,  Takahito Tamagawa ,  Okito Yamashita ,  Yusuke Takeda ,  Mitsuo Kawato ,  Kentaro Yamada ,  Masahiro Kimura ,  Akihiro Toda ,  Tatsuya Okabe

发明人： Masaaki Sato ,  Takahito Tamagawa ,  Okito Yamashita ,  Yusuke Takeda ,  Mitsuo Kawato ,  Kentaro Yamada ,  Masahiro Kimura ,  Akihiro Toda ,  Tatsuya Okabe

IPC分类号： A61B5/04 ,  B25J13/00 ,  G06F3/01 ,  G06N99/00 ,  A61B5/0476 ,  A61B5/00 ,  A61B5/055

CPC分类号： B25J13/00 ,  A61B5/0042 ,  A61B5/0059 ,  A61B5/0073 ,  A61B5/0476 ,  A61B5/055 ,  A61B5/4064 ,  A61B5/6814 ,  G06F3/015 ,  G06N99/005

摘要： A brain information output apparatus includes an intention determination information storage unit in which two or more pieces of intention determination information can be stored, with each intention determination information including a pair of an intention identifier, and a learning feature amount group including one or more feature amounts extracted from second learning data that is obtained by converting first learning data into intracerebral brain activity data, the first leaning data being acquired from the outside of the cranium of a user when the user performs a trial according to one intention; a first brain activity data acquiring unit that acquires first brain activity data from the outside of the cranium of a user; a second brain activity data acquiring unit that converts the first brain activity data to intracerebral brain activity data, and acquires second brain activity data; a feature amount group acquiring unit that acquires, from the second brain activity data, an input feature amount group including one or more feature amounts; an intention identifier acquiring unit that acquires an intention identifier corresponding to the input feature amount group based on the two or more pieces of intention determination information; and an intention identifier output unit that outputs the intention identifier.

摘要翻译： 大脑信息输出装置包括意图确定信息存储单元，其中可以存储两个或多个意图确定信息，每个意图确定信息包括一对意图标识符和包括一个或多个特征的学习特征量组 通过将第一学习数据转换为大脑脑活动数据而获得的第二学习数据提取的量，当用户根据一种意图进行试验时，从用户头颅的外部获取第一倾斜数据; 第一脑活动数据获取单元，从用户的头颅的外部获取第一脑活动数据; 第二大脑活动数据获取单元，将第一脑活动数据转换为大脑脑活动数据，并获取第二大脑活动数据; 特征量组获取单元，从第二大脑活动数据获取包括一个或多个特征量的输入特征量组; 意图标识符获取单元，基于所述两个或多个意图确定信息来获取与所述输入特征量组相对应的意图识别符; 以及输出意图标识符的意图标识符输出单元。

公开(公告)号：US08819946B2

公开(公告)日：2014-09-02

申请号：US12088052

申请日：2006-09-27

申请人： Masanobu Yamasaki ,  Takeshi Shiba ,  Juzaemon Iwasaki ,  Shinji Fujimoto ,  Masaaki Sato ,  Shunsuke Komori

发明人： Masanobu Yamasaki ,  Takeshi Shiba ,  Juzaemon Iwasaki ,  Shinji Fujimoto ,  Masaaki Sato ,  Shunsuke Komori

IPC分类号： B26B19/02 ,  B26B19/04

CPC分类号： B26B19/048

摘要： A support arm that is rockably supported on one end of a grip portion and projects from the one end is provided. Both ends of a blade head are supported by the support arm such that the blade head can rock around an axis extending along a reciprocating direction of an inner blade, and an axial direction of the rocking motion of the support arm with respect to the grip portion is set in a direction intersecting with the reciprocating direction of the inner blade. This configuration achieves an electric shaver capable of increasing the movable range of the blade head while preventing a main body from increasing in size.

摘要翻译： 提供了一种支撑臂，其可旋转地支撑在把手部分的一端并从该一端突出。 叶片头的两端由支撑臂支撑，使得叶片头部围绕沿着内叶片的往复运动方向延伸的轴线摇摆，并且支撑臂相对于把手部分的摇摆运动的轴向方向 设置在与内刀片的往复方向相交的方向上。 这种结构实现了能够增加刀头的可移动范围的电动剃须刀，同时防止主体尺寸增大。

公开(公告)号：US08753013B2

公开(公告)日：2014-06-17

申请号：US13482747

申请日：2012-05-29

申请人： Masaaki Sato ,  Masakazu Sato

发明人： Masaaki Sato ,  Masakazu Sato

IPC分类号： B65D30/16 ,  B65D33/02

CPC分类号： B29C45/14336 ,  B29C65/02 ,  B29C65/04 ,  B29C65/08 ,  B29C66/1122 ,  B29C66/133 ,  B29C66/3452 ,  B29C66/53263 ,  B29C66/71 ,  B29C66/72321 ,  B29C66/72325 ,  B29C66/72328 ,  B29C66/72341 ,  B29C66/7392 ,  B29C66/81423 ,  B29C66/81431 ,  B29C66/83221 ,  B65D75/008 ,  B65D75/5883 ,  Y10S383/906 ,  B29K2077/00 ,  B29K2023/04 ,  B29K2023/10 ,  B29K2067/003 ,  B29K2067/00 ,  B29K2023/00 ,  B29K2023/06 ,  B29K2023/083 ,  B29K2023/086 ,  B29K2023/12 ,  B29K2023/18 ,  B29K2023/38 ,  B29K2027/08

摘要： The self-standing bag comprises a package for accommodating a content, a port provided in the center of the top portion of the package, and reinforcing members formed of a thermoplastic resin which cover the outer faces of both side edges of the package. The lower end portion of the reinforcing member is located above the bottom edge of the package. The lower end portion of the reinforcing member is projected inward of a lower cutout.

摘要翻译： 自立袋包括用于容纳内容物的包装，设置在包装顶部的中心的端口和由覆盖包装的两个侧边缘的外表面的热塑性树脂形成的加强件。 加强件的下端部位于包装的底部边缘的上方。 加强构件的下端部从下部切口的内侧突出。

公开(公告)号：US08466273B2

公开(公告)日：2013-06-18

申请号：US12241868

申请日：2008-09-30

申请人： Kyoko Kohara ,  Michinori Kohara ,  Tomohiro Nishimura ,  Masaaki Sato

发明人： Kyoko Kohara ,  Michinori Kohara ,  Tomohiro Nishimura ,  Masaaki Sato

IPC分类号： C07H21/04

CPC分类号： C07K16/286 ,  C07K16/40 ,  C07K2317/73 ,  C07K2317/76

摘要： The present invention aims to provide hepatitis C virus inhibitors capable of inhibiting viral replication in hepatitis C virus-infected cells.The replication of hepatitis C virus can be inhibited and hepatitis C virus-infected cells can be specifically injured by specifically inhibiting BGT-1 or AKR1C1 involved in the replication of hepatitis C virus. Thus, viral inhibitors comprising a substance inhibiting BGT-1 or AKR1C1 are effective for the treatment of hepatitis C.

摘要翻译： 本发明旨在提供能够抑制丙型肝炎病毒感染细胞中病毒复制的丙型肝炎病毒抑制剂。 可以抑制丙型肝炎病毒的复制，通过特异性抑制丙型肝炎病毒复制中的BGT-1或AKR1C1可以特异性地损伤丙型肝炎病毒感染的细胞。 因此，包含抑制BGT-1或AKR1C1的物质的病毒抑制剂对于治疗丙型肝炎是有效的。

公开(公告)号：US08296955B2

公开(公告)日：2012-10-30

申请号：US12663870

申请日：2008-06-13

申请人： Masaaki Sato ,  Takeshi Shiba ,  Jyuzaemon Iwasaki

发明人： Masaaki Sato ,  Takeshi Shiba ,  Jyuzaemon Iwasaki

IPC分类号： B26B19/04 ,  B26B19/06

CPC分类号： B26B19/04

摘要： An electric shaver in which a blade frame part is attached to an upper portion of a body part, the blade frame part including an outer blade, an outer blade frame to fix the outer blade thereto, a holding frame to hold the outer blade frame vertically movable, and an outer peripheral frame connected to the holding frame, the upper portion including an inner blade. The holding frame is detachably attached to the outer peripheral frame from an under side thereof, and the outer peripheral frame entirely covers an outer periphery of the holding frame.

摘要翻译： 一种电动剃须刀，其中刀片框架部分附接到主体部分的上部，所述刀片框架部分包括外刀片，外刀片框架以将外刀片固定在其上;保持框架，用于将外刀片框架垂直地保持 以及与保持框架连接的外周框架，上部包括内刀片。 保持框架从其下侧可拆卸地附接到外周框架，并且外周框架完全覆盖保持框架的外周。