公开(公告)号：US08372394B2

公开(公告)日：2013-02-12

申请号：US12311426

申请日：2008-02-21

申请人： Norimasa Iwasaki ,  Akio Minami ,  Yasuhiko Kasahara ,  Tatsuya Igarashi ,  Daisuke Kawamura ,  Fumiyoshi Kasahara ,  Chihiro Miyajima ,  Nobuo Ohzawa ,  Mariko Imai

发明人： Norimasa Iwasaki ,  Akio Minami ,  Yasuhiko Kasahara ,  Tatsuya Igarashi ,  Daisuke Kawamura ,  Fumiyoshi Kasahara ,  Chihiro Miyajima ,  Nobuo Ohzawa ,  Mariko Imai

IPC分类号： A61K35/12

CPC分类号： A61K35/28 ,  A61K31/734 ,  A61L27/20 ,  A61L27/3834 ,  A61L27/3852 ,  A61L2430/06 ,  C08L5/04

摘要： The present invention provides a composition for regenerating cartilage or treating a cartilage disease containing a monovalent metal salt of alginic acid for which the endotoxin level thereof has been lowered to an extent that does not substantially induce inflammation or fever. As a result, it is possible to provide a composition for regenerating cartilage that improves cartilage regenerative action and ease of application to a cartilage injury lesion, and a composition for treating a cartilage disease, which has the effects of protecting cartilage from mechanical irritation, inhibiting degenerative changes in cartilage caused by wear and inflammation, repairing a cartilage injury lesion, and inhibiting inflammation and pain of joint tissue.

摘要翻译： 本发明提供一种用于再生软骨或治疗软骨疾病的组合物，其含有海藻酸的一价金属盐，其内毒素水平已被降低至基本上不引起炎症或发热的程度。 结果，可以提供一种提高软骨再生作用的软骨再生用软化组合物和软骨损伤损伤的易用性的组合物，以及用于治疗软骨疾病的组合物，其具有保护软骨免受机械刺激，抑制 由磨损和炎症引起的软骨退行性变化，修复软骨损伤病变，以及抑制关节组织的炎症和疼痛。

公开(公告)号：US20100015102A1

公开(公告)日：2010-01-21

申请号：US12311426

申请日：2008-02-21

申请人： Norimasa Iwasaki ,  Akio Minami ,  Yasuhiko Kasahara ,  Tatsuya Igarashi ,  Daisuke Kawamura ,  Fumiyoshi Kasahara ,  Chihiro Miyajima ,  Nobuo Ohzawa ,  Mariko Imai

发明人： Norimasa Iwasaki ,  Akio Minami ,  Yasuhiko Kasahara ,  Tatsuya Igarashi ,  Daisuke Kawamura ,  Fumiyoshi Kasahara ,  Chihiro Miyajima ,  Nobuo Ohzawa ,  Mariko Imai

IPC分类号： A61K35/12 ,  A61K31/715 ,  A61P19/04

CPC分类号： A61K35/28 ,  A61K31/734 ,  A61L27/20 ,  A61L27/3834 ,  A61L27/3852 ,  A61L2430/06 ,  C08L5/04

摘要： The present invention provides a composition for regenerating cartilage or treating a cartilage disease containing a monovalent metal salt of alginic acid for which the endotoxin level thereof has been lowered to an extent that does not substantially induce inflammation or fever. As a result, it is possible to provide a composition for regenerating cartilage that improves cartilage regenerative action and ease of application to a cartilage injury lesion, and a composition for treating a cartilage disease, which has the effects of protecting cartilage from mechanical irritation, inhibiting degenerative changes in cartilage caused by wear and inflammation, repairing a cartilage injury lesion, and inhibiting inflammation and pain of joint tissue.

摘要翻译： 本发明提供一种用于再生软骨或治疗软骨疾病的组合物，其含有海藻酸的一价金属盐，其内毒素水平已被降低至基本上不引起炎症或发热的程度。 结果，可以提供一种提高软骨再生作用的软骨再生用软化组合物和软骨损伤损伤的易用性的组合物，以及用于治疗软骨疾病的组合物，其具有保护软骨免受机械刺激，抑制 由磨损和炎症引起的软骨退行性变化，修复软骨损伤病变，以及抑制关节组织的炎症和疼痛。

公开(公告)号：US08367637B2

公开(公告)日：2013-02-05

申请号：US12461660

申请日：2009-08-19

申请人： Norimasa Iwasaki ,  Akio Minami ,  Yasuhiko Kasahara ,  Tatsuya Igarashi ,  Daisuke Kawamura ,  Nobuo Ohzawa ,  Mariko Imai

发明人： Norimasa Iwasaki ,  Akio Minami ,  Yasuhiko Kasahara ,  Tatsuya Igarashi ,  Daisuke Kawamura ,  Nobuo Ohzawa ,  Mariko Imai

IPC分类号： A61K31/734 ,  A61P19/02 ,  C08B37/04

CPC分类号： A61K31/715

摘要： The present invention provides compositions and methods for treating a joint disease containing as an active ingredient thereof a monovalent metal salt of alginic acid for which the endotoxin level thereof has been lowered to an extent that does not substantially induce inflammation or fever. As a result, it is possible to provide a composition for treating a joint disease which has the effects of protecting cartilage from mechanical irritation, inhibiting degenerative changes in cartilage caused by wear and inflammation, repairing cartilage injuries, suppressing inflammation and pain of joint tissue, inhibiting degeneration of synovial tissue, and inhibiting osteochondral destruction.

摘要翻译： 本发明提供用于治疗关节疾病的组合物和方法，其含有作为其活性成分的海藻酸的一价金属盐，其内毒素水平已被降低至基本上不诱导炎症或发热的程度。 结果，可以提供一种治疗关节疾病的组合物，其具有保护软骨免受机械刺激的作用，抑制由磨损和炎症引起的软骨的退行性变化，修复软骨损伤，抑制炎症和关节组织的疼痛， 抑制滑膜组织变性，抑制骨软骨破坏。

公开(公告)号：US20100048506A1

公开(公告)日：2010-02-25

申请号：US12461660

申请日：2009-08-19

申请人： Norimasa Iwasaki ,  Akio Minami ,  Yasuhiko Kasahara ,  Tatsuya Igarashi ,  Daisuke Kawamura ,  Nobuo Ohzawa ,  Mariko Imai

发明人： Norimasa Iwasaki ,  Akio Minami ,  Yasuhiko Kasahara ,  Tatsuya Igarashi ,  Daisuke Kawamura ,  Nobuo Ohzawa ,  Mariko Imai

IPC分类号： A61K31/715 ,  A61P19/02

CPC分类号： A61K31/715

摘要： The present invention provides compositions and methods for treating a joint disease containing as an active ingredient thereof a monovalent metal salt of alginic acid for which the endotoxin level thereof has been lowered to an extent that does not substantially induce inflammation or fever. As a result, it is possible to provide a composition for treating a joint disease which has the effects of protecting cartilage from mechanical irritation, inhibiting degenerative changes in cartilage caused by wear and inflammation, repairing cartilage injuries, suppressing inflammation and pain of joint tissue, inhibiting degeneration of synovial tissue, and inhibiting osteochondral destruction.

摘要翻译： 本发明提供用于治疗关节疾病的组合物和方法，其含有作为其活性成分的海藻酸的一价金属盐，其内毒素水平已被降低至基本上不引起炎症或发热的程度。 结果，可以提供一种治疗关节疾病的组合物，其具有保护软骨免受机械刺激的作用，抑制由磨损和炎症引起的软骨的退行性变化，修复软骨损伤，抑制炎症和关节组织的疼痛， 抑制滑膜组织变性，抑制骨软骨破坏。