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    Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof
    3.
    发明授权
    Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof 失效
    带有3-吡啶基的取代噻唑衍生物，其制备方法及其应用

    公开(公告)号：US07067537B2

    公开(公告)日：2006-06-27

    申请号：US10433910

    申请日：2001-12-07

    申请人： Noritaka Kuroda ,  Yoshi Nara ,  Shohei Hashiguchi ,  Akihiro Tasaka ,  Masami Kusaka ,  Masuo Yamaoka ,  Tomohiro Kaku

    发明人： Noritaka Kuroda ,  Yoshi Nara ,  Shohei Hashiguchi ,  Akihiro Tasaka ,  Masami Kusaka ,  Masuo Yamaoka ,  Tomohiro Kaku

    IPC分类号： A01N43/40 ,  A61K31/44

    CPC分类号： C07D417/04 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/4725 ,  C07D417/14

    摘要： The present invention provides a pharmaceutical composition having a steroid C17,20-lyase inhibitory activity, which is useful as a prophylactic or therapeutic agent of prostatism, tumor such as breast cancer and the like, more particularly, a steroid C17,20-lyase inhibitor containing a compound represented by the formula: wherein A1 is an aromatic hydrocarbon group optionally having substituents or a heterocyclic group optionally having substituents, one of A2 and A3 is a hydrogen atom, a halogen atom, a C1-4 aliphatic hydrocarbon group optionally having substituents or an optionally esterified carboxyl group, the other of A2 and A3 is an aromatic hydrocarbon group optionally having substituents or a heterocyclic group optionally having substituents, and at least one of A1, A2 and A3 is a 3-pyridyl group optionally having substituents, or a salt thereof or a prodrug thereof.

    摘要翻译： 本发明提供了具有类固醇C 17-20半胱氨酸酶抑制活性的药物组合物，其可用作前列腺症的预防或治疗剂，诸如乳腺癌等肿瘤，更具体地， 含有由下式表示的化合物的类固醇C 17-20重量酶抑制剂：其中A 1是任选具有取代基的芳族烃基或任选具有取代基的杂环基， A 2和A 3之一是氢原子，卤素原子，任选具有取代基的C 1-4烷基脂族烃基或 任选地酯化的羧基，A 2和A 3中的另一个是任选具有取代基的芳族烃基或任选具有取代基的杂环基，并且A < SUP> 1，A 2和A 3是任选具有取代基的3-吡啶基，或其盐或前药 其中。