公开(公告)号：US5886197A

公开(公告)日：1999-03-23

申请号：US826504

申请日：1997-04-03

申请人： Noriyasu Hirose ,  Hiroshi Inoue ,  Toshio Matsunami ,  Takashi Yoshimura ,  Kouzou Morita ,  Yuh Horikawa ,  Noriyoshi Iwata ,  Norio Minami ,  Kenji Hayashi ,  Chiaki Seki

发明人： Noriyasu Hirose ,  Hiroshi Inoue ,  Toshio Matsunami ,  Takashi Yoshimura ,  Kouzou Morita ,  Yuh Horikawa ,  Noriyoshi Iwata ,  Norio Minami ,  Kenji Hayashi ,  Chiaki Seki

IPC分类号： C07D311/72 ,  C07D311/74 ,  C07C2/58 ,  C07D311/62 ,  C07D311/64

CPC分类号： C07D311/72

摘要： A process is provided for the preparation of .alpha.-tocopherol. According to the process, a condensation reaction between trimethylhydroquinone and a specific phytol derivative or isophytol is conducted in the presence of any one of the following solvents:(i) a carbonate ester,(ii) a lower fatty acid ester represented by the following formula:R.sup.1 COOR.sup.2wherein R.sup.1 means a lower alkyl group having 1-4 carbon atoms and R.sup.2 means a lowe alkyl group having 1-5 carbon atoms with the proviso that methyl acetate and ethyl acetate are excluded;(iii) a mixed solvent of a nonpolar solvent and a lower alcohol having 1-5 carbon atoms; and(iv) a mixed solvent of the nonpolar solvent and the lower fatty acid ester.

摘要翻译： 提供了一种制备α-生育酚的方法。 根据该方法，在以下任一种溶剂的存在下进行三甲基对苯二酚与特定植物醇衍生物或异麦芽糖醇的缩合反应：（i）碳酸酯，（ii）由下式表示的低级脂肪酸酯 ：R1COOR2其中R1表示具有1-4个碳原子的低级烷基，R2表示具有1-5个碳原子的低级烷基，条件是不包括乙酸甲酯和乙酸乙酯; （iii）非极性溶剂和具有1-5个碳原子的低级醇的混合溶剂; 和（iv）非极性溶剂和低级脂肪酸酯的混合溶剂。

公开(公告)号：US5663376A

公开(公告)日：1997-09-02

申请号：US460667

申请日：1995-06-02

申请人： Noriyasu Hirose ,  Hiroshi Inoue ,  Toshio Matsunami ,  Takashi Yoshimura ,  Kouzou Morita ,  Yuh Horikawa ,  Noriyoshi Iwata ,  Norio Minami ,  Kenji Hayashi ,  Chiaki Seki

发明人： Noriyasu Hirose ,  Hiroshi Inoue ,  Toshio Matsunami ,  Takashi Yoshimura ,  Kouzou Morita ,  Yuh Horikawa ,  Noriyoshi Iwata ,  Norio Minami ,  Kenji Hayashi ,  Chiaki Seki

IPC分类号： C07D311/72

CPC分类号： C07D311/72

摘要： A process is provided for the preparation of .alpha.-tocopherol. According to the process, a condensation reaction between trimethylhydroquinone and a specific phytol derivative or isophytol is conducted in the presence of any one of the following solvents:(i) a carbonate ester,(ii) a lower fatty acid ester represented by the following formula:R.sup.1 COOR.sup.2wherein R.sup.1 means a lower alkyl group having 1-4 carbon atoms and R.sup.2 means a lower alkyl group having 1-5 carbon atoms with the proviso that methyl acetate and ethyl acetate are excluded;(iii) a mixed solvent of a nonpolar solvent and a lower alcohol having 1-5 carbon atoms; and(iv) a mixed solvent of the nonpolar solvent and the lower fatty acid ester.

摘要翻译： 提供了一种制备α-生育酚的方法。 根据该方法，在以下任一种溶剂的存在下进行三甲基对苯二酚与特定植物醇衍生物或异麦芽糖醇的缩合反应：（i）碳酸酯，（ii）由下式表示的低级脂肪酸酯 ：R1COOR2其中R1表示具有1-4个碳原子的低级烷基，R2表示具有1-5个碳原子的低级烷基，条件是不包括乙酸甲酯和乙酸乙酯; （iii）非极性溶剂和具有1-5个碳原子的低级醇的混合溶剂; 和（iv）非极性溶剂和低级脂肪酸酯的混合溶剂。

公开(公告)号：US6020505A

公开(公告)日：2000-02-01

申请号：US210663

申请日：1998-12-14

申请人： Noriyasu Hirose ,  Hiroshi Inoue ,  Toshio Matsunami ,  Takashi Yoshimura ,  Kouzou Morita ,  Yuh Horikawa ,  Noriyoshi Iwata ,  Norio Minami ,  Kenji Hayashi ,  Chiaki Seki

发明人： Noriyasu Hirose ,  Hiroshi Inoue ,  Toshio Matsunami ,  Takashi Yoshimura ,  Kouzou Morita ,  Yuh Horikawa ,  Noriyoshi Iwata ,  Norio Minami ,  Kenji Hayashi ,  Chiaki Seki

IPC分类号： C07D311/72 ,  C07D311/20

CPC分类号： C07D311/72

摘要： A process is provided for the preparation of .alpha.-tocopherol. According to the process, a condensation reaction between trimethylhydroquinone and a specific phytol derivative or isophytol is conducted in the presence of any one of the following solvents:(i) a carbonate ester;(ii) a lower fatty acid ester represented by the following formula:R.sup.1 COOR.sup.2 wherein R.sup.1 means a lower alkyl group having 1-4 carbon atoms and R.sup.2 means a lower alkyl group having 1-5 carbon atoms with the proviso that methyl acetate and ethyl acetate are excluded;(iii) a mixed solvent of a nonpolar solvent and a lower alcohol having 1-5 carbon atoms; and(iv) a mixed solvent of the nonpolar solvent and the lower fatty acid ester.

摘要翻译： 提供了一种制备α-生育酚的方法。 根据该方法，在以下任一种溶剂的存在下进行三甲基对苯二酚与特定的植物醇衍生物或异植醇之间的缩合反应：（i）碳酸酯; （ii）由下式表示的低级脂肪酸酯：R1COOR2其中R1表示具有1-4个碳原子的低级烷基，R2表示具有1-5个碳原子的低级烷基，条件是乙酸甲酯和乙酸乙酯 被排除在外; （iii）非极性溶剂和具有1-5个碳原子的低级醇的混合溶剂; 和（iv）非极性溶剂和低级脂肪酸酯的混合溶剂。